dc.contributor.author | Aksoy, Ayşe Nur | |
dc.contributor.author | Kücür, Suna Kabil | |
dc.contributor.author | Batmaz, Gonca | |
dc.contributor.author | Gözükara, İlay | |
dc.contributor.author | Aksoy, Mehmet | |
dc.contributor.author | Kurt, Nezahat | |
dc.contributor.author | Mammadov, Renad | |
dc.date.accessioned | 2020-12-19T19:58:32Z | |
dc.date.available | 2020-12-19T19:58:32Z | |
dc.date.issued | 2015 | |
dc.identifier.citation | Aksoy, A.N., Kucur, S.K., Batmaz, G.,Gozukara, I., Aksoy, M., Kurt, N., Mammadov, R. (2015). The role of antioxidant activity in the prevention and treatment of infertility caused by cisplatin in rats. Gynecologic and Obstetric Investigation, 79(2), 119-125. https://doi.org/10.1159/000367657 | en_US |
dc.identifier.issn | 0378-7346 | |
dc.identifier.issn | 1423-002X | |
dc.identifier.uri | https://doi.org/10.1159/000367657 | |
dc.identifier.uri | https://hdl.handle.net/11436/2982 | |
dc.description | Kurt, Nezahat/0000-0002-1685-5332; AKSOY, Ayse Nur/0000-0002-3793-9797; AKSOY, Mehmet/0000-0003-0867-8660 | en_US |
dc.description | WOS: 000350267200009 | en_US |
dc.description | PubMed: 25632879 | en_US |
dc.description.abstract | Background/Aims:To investigate the importance of antioxidant activity in infertility caused by cisplatin in rats. Methods: Rats in cisplatin control (CG), Vitamin E+cisplatin (ECG), Vitamin C + cisplatin (CCG), Hippophae rhamnoides extract (HRE) + cisplatin (HRECG), and thiamine pyrophosphate (TPP) + cisplatin (TPPCG) groups were injected intraperitoneally (ip) with (100 mg/kg) Vitamin E, Vitamin C, HRE, and TPP, respectively. One hour later, ip cisplatin was administered (5 mg/kg), and then antioxidant medications were continued for 10 days. Cisplatin + Vitamin E (CEG-1), cisplatin + Vitamin C (CCG-1), cisplatin + HRE (CHREG-1), and cisplatin + TPP (TPPCG-1) rats received cisplatin (5 mg/kg, ip) and were kept for 10 days. At the end of that period, rats received antioxidant medications for 10 days. (n = 12, for each group). Six rats from each group were sacrificed. Ovaries were removed to measure malondialdehyde, total glutathione, glutathione S-transferase, and glutathione reductase levels. the remaining rats were kept in a suitable laboratory environment. Results: Cisplatin-induced oxidative stress was best prevented by HRE, Vitamin E, Vitamin C, and TPP, in that order. However, infertility caused by cisplatin was only prevented and treated by TPP. Conclusion: Oxidative stress is not a major component in the pathogenesis of cisplatin-associated infertility. (C) 2015 S. Karger AG, Basel | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Karger | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | Antioxidant activity | en_US |
dc.subject | Oxidative stress | en_US |
dc.subject | Cisplatin | en_US |
dc.subject | Infertility | en_US |
dc.subject | Rat | en_US |
dc.title | The role of antioxidant activity in the prevention and treatment of infertility caused by cisplatin in rats | en_US |
dc.type | article | en_US |
dc.contributor.department | RTEÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü | en_US |
dc.contributor.institutionauthor | Mammadov, Renad | |
dc.identifier.doi | 10.1159/000367657 | |
dc.identifier.volume | 79 | en_US |
dc.identifier.issue | 2 | en_US |
dc.identifier.startpage | 119 | en_US |
dc.identifier.endpage | 125 | en_US |
dc.relation.journal | Gynecologic and Obstetric Investigation | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |