dc.contributor.author | Ceylan, Şule | |
dc.contributor.author | Bayrak, Hacer | |
dc.contributor.author | Demirbaş, Ahmet | |
dc.contributor.author | Ülker, Serdar | |
dc.contributor.author | Alpay-Karaoğlu, Şengül | |
dc.contributor.author | Demirbaş, Neslihan | |
dc.date.accessioned | 2020-12-19T20:03:14Z | |
dc.date.available | 2020-12-19T20:03:14Z | |
dc.date.issued | 2014 | |
dc.identifier.citation | Ceylan, S., Bayrak, H., Demirbas, A., Ulker, S., Alpay-Karaoglu, S., Demirbas, N. (2014). Synthesis of some new hybride molecules containing several azole moieties and investigation of their biological activities. Russian Journal of Bioorganic Chemistry, 40(3), 314-329. https://doi.org/10.1134/S1068162014030145 | en_US |
dc.identifier.issn | 1068-1620 | |
dc.identifier.issn | 1608-330X | |
dc.identifier.uri | https://doi.org/10.1134/S1068162014030145 | |
dc.identifier.uri | https://hdl.handle.net/11436/3127 | |
dc.description | Alpay Karaoglu, Sengul/0000-0003-1047-8350 | en_US |
dc.description | WOS: 000336054000011 | en_US |
dc.description.abstract | 1,2,4-Triazole-3-one prepared from tryptamine was converted to the corresponding carbothioamides by several steps. Their treatment with ethyl bromoacetate or 4-chlorophenacyl bromide produced the corresponding 5-oxo-1,3-thiazolidine or 3-(4-chlorophenyl)-1,3-thiazole derivatives. Acetohydrazide derivative that was obtained starting from tryptamine, was converted to the corresponding Schiff basis and sulfonamide by the treatment with suitable aldehydes and benzensulphonyl chloride, respectively. 2-[(4-Amino-5-thioxo-4,5-dihydro-1H-1,2,4-triazole-3-yl)methyl]-4-[2-(1H-indole-3-yl)ethyl]-5-methyl-2,4-dihydro-3H-1,2,4-triazole-3-one was synthesized starting from hydrazide via the formation of the corresponding 1,3,4-oxadiazole compound, while the other bitriazole compounds were obtained by intramolecular cyclisation of carbothioamides in basic media. the treatment of 1,2,4-triazole or 1,3,4-oxadiazole compound with several amines generated the corresponding Mannich bases. Ethyl (2-amino-1,3-thiazole-4-yl)acetate was converted to the corresponding 1,3,4-oxadiazole derivative, arylidenehydrazides, 1,2,4-triazole-3-one and 5-oxo-1,3-oxazolidine derivatives by several steps. the structural assignments of new compounds were based on their elemental analysis and spectral (FT IR, H-1 NMR, C-13 NMR and LC-MS) data. the antimicrobial, antilipase and antiurease activity studies revealed that some of the synthesized compounds showed antimicrobial, antilipase and/or antiurease activity. | en_US |
dc.description.sponsorship | Karadeniz Technical University, BAP, TurkeyKaradeniz Technical University [8623, 8663, 10641] | en_US |
dc.description.sponsorship | This work was supported by Karadeniz Technical University, BAP, Turkey (Ref. nos. 8623, 8663 and 10641). | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Maik Nauka/Interperiodica/Springer | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | 1,2,4-triazole | en_US |
dc.subject | 1,3,4-oxadiazole | en_US |
dc.subject | 1,3-thiazolidinone | en_US |
dc.subject | 1,3,4-thiadiazole | en_US |
dc.subject | piperazine | en_US |
dc.subject | Biological activity | en_US |
dc.title | Synthesis of some new hybride molecules containing several azole moieties and investigation of their biological activities | en_US |
dc.type | article | en_US |
dc.contributor.department | RTEÜ, Fen - Edebiyat Fakültesi, Biyoloji Bölümü | en_US |
dc.contributor.institutionauthor | Ülker, Serdar | |
dc.contributor.institutionauthor | Alpay-Karaoğlu, Şengül | |
dc.identifier.doi | 10.1134/S1068162014030145 | |
dc.identifier.volume | 40 | en_US |
dc.identifier.issue | 3 | en_US |
dc.identifier.startpage | 314 | en_US |
dc.identifier.endpage | 329 | en_US |
dc.relation.journal | Russian Journal of Bioorganic Chemistry | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |