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dc.contributor.authorYapca, Ömer Erkan
dc.contributor.authorTuran, Mehmet İbrahim
dc.contributor.authorBörekçi, Bünyamin
dc.contributor.authorAkçay, Fatih
dc.contributor.authorSüleyman, Halis
dc.date.accessioned2020-12-19T20:03:16Z
dc.date.available2020-12-19T20:03:16Z
dc.date.issued2014
dc.identifier.citationYapca, O. E., Turan, M. I., Borekci, B., Akcay, F., & Suleyman, H. (2014). Bilateral ovarian ischemia/reperfusion injury and treatment options in rats with an induced model of diabetes. Iranian journal of basic medical sciences, 17(4), 294–302.en_US
dc.identifier.issn2008-3866
dc.identifier.issn2008-3874
dc.identifier.urihttps://hdl.handle.net/11436/3133
dc.descriptionWOS: 000345352100010en_US
dc.descriptionPubMed: 24904723en_US
dc.description.abstractObjective(s): This study investigated the effects of melatonin, famotidine, mirtazapine, and thiamine pyrophosphate on ischemia/ reperfusion (I/ R) injury in diabetic rats and evaluated oxidant and antioxidant marker measurement results. It also examined the effects of the drugs aimed at preventing infertility that may result from I/ R injury. Materials and Methods: Diabetic rats were divided into a control group (IRC) to be exposed to I/ R, an ovarian I/ R + 2.2 mg/ kg melatonin (IRML) group, an ovarian I/ R + famotidine (IRFA) group, an ovarian I/ R + 20 mg/ kg mirtazapine (IRMR) group, an ovarian I/ R + 20 mg/ kg thiamine pyrophosphate (IRTP) group, and a sham operation (SO) group. Results: in the control group exposed to I/ R, the levels of the oxidant parameters Malondialdehyde (MDA) and Myeloperoxidase (MPO) were significantly higher compared with the SO group, while the levels of the antioxidant parameters glutathione (GSH), Glutathione peroxidase (GPO), Glutathione reductase (GSHRd), Glutathione S - transferase (GST), and Superoxide dismutase (SOD) were significantly lower. Melatonin, famotidine, mirtazapine, and thiamin pyrophosphate prevented a rise in oxidant parameters and a decrease in antioxidants in ovarian tissue exposed to I/R. However, apart from thiamin pyrophosphate, none of the drugs were able to prevent infertility caused by I/R injury. Conclusion: Prevention of ovarian I/R injury-related infertility in rats with induced diabetes is not through antioxidant activity. Thiamine pyrophosphate prevents infertility through an as yet unknown mechanism. This study suggests that thiamine pyrophosphate may be useful in the prevention of I/R-related infertility in diabetics.en_US
dc.language.isoengen_US
dc.publisherMashhad Univ Med Sciencesen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectDiabetes mellitusen_US
dc.subjectInfertilityen_US
dc.subjectInjuryen_US
dc.subjectIschemia/reperfusionen_US
dc.subjectOvaryen_US
dc.subjectRaten_US
dc.titleBilateral ovarian ischemia/reperfusion injury and treatment options in rats with an induced model of diabetesen_US
dc.typearticleen_US
dc.contributor.departmentRTEÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.contributor.institutionauthorSüleyman, Halis
dc.identifier.volume17en_US
dc.identifier.issue4en_US
dc.identifier.startpage294en_US
dc.identifier.endpage302en_US
dc.ri.editoaen_US
dc.relation.journalIranian Journal of Basic Medical Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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