dc.contributor.author | Demirci, Serpil | |
dc.contributor.author | Demirbaş, Ahmet | |
dc.contributor.author | Ülker, Serdar | |
dc.contributor.author | Alpay-Karaoğlu, Şengül | |
dc.contributor.author | Demirbaş, Neslihan | |
dc.date.accessioned | 2020-12-19T20:03:23Z | |
dc.date.available | 2020-12-19T20:03:23Z | |
dc.date.issued | 2014 | |
dc.identifier.citation | Demirci, S., Demirbas, A., Ulker, S., Alpay-Karaoglu, S., Demirbas, N. (2014). Synthesis of some heterofunctionalized penicillanic acid derivatives and investigation of their biological activities. Archiv Der Pharmazie, 347(3), 200-220. https://doi.org/10.1002/ardp.201300280 | en_US |
dc.identifier.issn | 0365-6233 | |
dc.identifier.issn | 1521-4184 | |
dc.identifier.uri | https://doi.org/10.1002/ardp.201300280 | |
dc.identifier.uri | https://hdl.handle.net/11436/3156 | |
dc.description | Alpay Karaoglu, Sengul/0000-0003-1047-8350 | en_US |
dc.description | WOS: 000332331800006 | en_US |
dc.description | PubMed: 24293403 | en_US |
dc.description.abstract | 6-Substituted amino-penicillanic acid esters were synthesized starting with 6-apa. the compounds containing a 1,3-thiazole- or 1,3-thiazolidinone nucleus linked to the penicillanic acid skeleton via a hydrazino linkage were obtained from 6-apa. the treatment of carbonylamino and carbonothioylamino compounds with 4-chlorophenacyl bromide or ethyl bromoacetate gave 6-bis{4-[1,3-thiazol(idinone)amino]benzoyl}amino derivatives of 6-apa. Benzyl derivatives were synthesized in several steps, starting with 4-aminobenzoyl chloride. the treatment of 4-{[3-benzyl-4-oxo-1,3-thia(oxa)zolidin-2-ylidene]amino}benzoyl chlorides with 6-apa in ethanolic solution produced the 6-[bis(4-{[3-benzyl-4-oxo-1,3-thiazolidin-2-ylidene]amino}benzoyl)amino] derivative of penicillanic acid, while the reaction of the same intermediates in DMF gave the mono-substituted amino derivative of 6-apa. the synthesized compounds were screened for their biological activities, and some of them were found to possess good to moderate antimicrobial activity. Moreover, some of the compounds displayed antiurease, anti--lactamase, and/or antilipase activities. | en_US |
dc.description.sponsorship | Scientific and Technological Research Council of Turkey (TUBITAK)Turkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [111T427] | en_US |
dc.description.sponsorship | The support provided by Scientific and Technological Research Council of Turkey (TUBITAK, Project no: 111T427) is gratefully acknowledged. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Wiley-V C H Verlag Gmbh | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | 6-Amino penicillanic acid | en_US |
dc.subject | Anti -lactamase activity | en_US |
dc.subject | Antilipase activity | en_US |
dc.subject | Antimicrobial activity | en_US |
dc.subject | Anti-urease activity | en_US |
dc.subject | 1 | en_US |
dc.subject | 3-Oxa(thia)zole | en_US |
dc.title | Synthesis of some heterofunctionalized penicillanic acid derivatives and investigation of their biological activities | en_US |
dc.type | article | en_US |
dc.contributor.department | RTEÜ, Fen - Edebiyat Fakültesi, Biyoloji Bölümü | en_US |
dc.contributor.institutionauthor | Ülker, Serdar | |
dc.contributor.institutionauthor | Alpay-Karaoğlu, Şengül | |
dc.identifier.doi | 10.1002/ardp.201300280 | |
dc.identifier.volume | 347 | en_US |
dc.identifier.issue | 3 | en_US |
dc.identifier.startpage | 200 | en_US |
dc.identifier.endpage | 220 | en_US |
dc.relation.journal | Archiv Der Pharmazie | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |