dc.contributor.author | Ekici, Feyzahan | |
dc.contributor.author | Karaca, Emine Esra | |
dc.contributor.author | Korkmaz, Şafak | |
dc.contributor.author | Yüksel, Osman | |
dc.contributor.author | Gülbahar, Özlem | |
dc.contributor.author | Alper, Murat | |
dc.contributor.author | Ercan, Sevim | |
dc.contributor.author | Or, Meral | |
dc.date.accessioned | 2020-12-19T20:03:35Z | |
dc.date.available | 2020-12-19T20:03:35Z | |
dc.date.issued | 2014 | |
dc.identifier.citation | Ekici, F., Karaca, E.E., Korkmaz, S., Yuksel, O., Gulbahar, O., Alper, M., Ercan, S., Or, M., (2014). Effect of the Toll-Like Receptor 4 Antagonist Eritoran on Retinochoroidal Inflammatory Damage in a Rat Model of Endotoxin-Induced Inflammation. Mediators of Inflammation, 2014. https://doi.org/10.1155/2014/643525 | |
dc.identifier.issn | 0962-9351 | |
dc.identifier.issn | 1466-1861 | |
dc.identifier.uri | https://doi.org/10.1155/2014/643525 | |
dc.identifier.uri | https://hdl.handle.net/11436/3201 | |
dc.description | alper, murat/0000-0001-7069-0623; Uzun, Feyzahan/0000-0002-3050-0714 | en_US |
dc.description | WOS: 000338073500001 | en_US |
dc.description | PubMed: 25165412 | en_US |
dc.description.abstract | Purpose. We investigated the effect of eritoran, a Toll-like receptor 4 antagonist, on retinochoroidal inflammatory damage in an endotoxin-induced inflammatory rat model. Methods. Endotoxin-induced inflammatory model was obtained by intraperitoneal injection of 1.5mg/kg lipopolysaccharide (LPS). Group 1 had control rats; in groups 2-3 LPS and 0.5mg/kg sterile saline were injected; and in groups 4-5 LPS and 0.5mg/kg eritoran were injected. Blood samples were taken and eyes were enucleated after 12 hours (h) (groups 2 and 4) or 24 hours (Groups 3 and 5). Tumor necrosis factor-alpha (TNF-alpha) and malondialdehyde (MDA) levels in the serum and retinochoroidal tissue and nuclear factor kappa-B (NF kappa B) levels in retinochoroidal tissue were determined. Histopathological examination was performed and retinochoroidal changes were scored. Results. Eritoran treatment resulted in lower levels of TNF-alpha, MDA, and NF kappa B after 12 h which became significant after 24 h. Serum TNF-alpha and retinochoroidal tissue NF kappa B levels were similar to control animals at the 24th h of the study. Eritoran significantly reversed histopathological damage after 24 h. Conclusions. Eritoran treatment resulted in less inflammatory damage in terms of serum and retinochoroidal tissue parameters. | en_US |
dc.description.sponsorship | Gazi University Scientific Projects and Research CenterGazi University [01/2007-75] | en_US |
dc.description.sponsorship | Gazi University Scientific Projects and Research Center supported this work with a Project no. 01/2007-75. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Hindawi Ltd | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | Tumor necrosis factor | en_US |
dc.subject | Induced uveitis | en_US |
dc.subject | Lipid peroxidation | en_US |
dc.subject | Ocular inflammation | en_US |
dc.subject | Tnf alpha | en_US |
dc.subject | Expression | en_US |
dc.subject | Injection | en_US |
dc.subject | Mechanism | en_US |
dc.title | Effect of the toll-like receptor 4 antagonist eritoran on retinochoroidal inflammatory damage in a rat model of endotoxin-induced inflammation | en_US |
dc.type | article | en_US |
dc.contributor.department | RTEÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü | en_US |
dc.contributor.institutionauthor | Ekici, Feyzahan | |
dc.identifier.doi | 10.1155/2014/643525 | |
dc.identifier.volume | 2014 | en_US |
dc.ri.edit | oa | en_US |
dc.relation.journal | Mediators of Inflammation | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |