dc.contributor.author | Altuner, Durdu | |
dc.contributor.author | Çetin, Nihal | |
dc.contributor.author | Süleyman, Bahadır | |
dc.contributor.author | Aslan, Zeynep | |
dc.contributor.author | Hacımuftuoğlu, Ahmet | |
dc.contributor.author | Gülaboğlu, Mine | |
dc.contributor.author | İsaoğlu, Neslihan | |
dc.contributor.author | Demiryılmaz, İsmail | |
dc.contributor.author | Suleyman, Halis | |
dc.date.accessioned | 2020-12-19T20:04:20Z | |
dc.date.available | 2020-12-19T20:04:20Z | |
dc.date.issued | 2013 | |
dc.identifier.citation | Altuner, D., Cetin, N., Süleyman, B., Aslan, Z., Hacımüftüoğlu, A., Gülaboğlu, M., İsaoğlu, N., (2013). Effect of thiamine pyrophosphate on ischemia-reperfusion induced oxidative damage in rat kidney. Indian Journal of Pharmacology, 45(4), 339-343. https://doi.org/10.4103/0253-7613.115005 | |
dc.identifier.issn | 0253-7613 | |
dc.identifier.issn | 1998-3751 | |
dc.identifier.uri | https://doi.org/10.4103/0253-7613.115005 | |
dc.identifier.uri | https://hdl.handle.net/11436/3315 | |
dc.description | Hacimuftuoglu, Ahmet/0000-0002-9658-3313; Cetin, Nihal/0000-0003-3233-8009 | en_US |
dc.description | WOS: 000322775000005 | en_US |
dc.description | PubMed: 24014907 | en_US |
dc.description.abstract | Objectives: the biochemical effects of thiamine pyrophosphate on ischemia-reperfusion (IR) induced oxidative damage and DNA mutation in rat kidney tissue were investigated, and compared to thiamine. Materials and Methods: Rats were divided into four groups: Renal ischemia-reperfusion (RIR); thiamine pyrophosphate + RIR (TPRIR); thiamine + RIR (TRIR); and sham group (SG). Results: the results of biochemical experiments have shown that malondialdehyde (MDA) levels in rat kidney tissue after TRIR and TPRIR treatment were 7.2 +/- 0.5 (P > 0.05) and 3.3 +/- 0.3 (P < 0.0001) mu mol/g protein, respectively. the MDA levels in the SG rat kidney tissue and in RIR group were 3.6 +/- 0.2 (P < 0.0001) and 7.6 +/- 0.6 mu mol/g protein, respectively. Total glutathione (tGSH) levels in TRIR, TPRIR, SG, and RIR animal groups were 2.2 +/- 0.3 (P > 0.05), 5.8 +/- 0.4 (P < 0.0001), 6.2 +/- 0.2 (P < 0.0001), and 1.7 +/- 0.2 nmol/g protein, respectively. in the TRIR, TPRIR, SG, and RIR animal groups; 8-hydroxyguanine (8-OHGua)/Gua levels, which indicate mutagenic DNA, were 1.75 +/- 0.12 (P > 0.05), 0.93 +/- 0.1 (P < 0.0001), 0.85 +/- 0.08 (P < 0.0001), and 1.93 +/- 0.24 pmol/L, respectively. Conclusions: It has been shown that thiamine pyrophosphate prevents increase in mutagenic DNA in IR induced oxidative damage, whereas thiamine does not have this effect. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Wolters Kluwer Medknow Publications | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | DNA mutation | en_US |
dc.subject | Ischemia-reperfusion | en_US |
dc.subject | Oxidative damage | en_US |
dc.subject | Rat | en_US |
dc.subject | Thiamine pyrophosphate | en_US |
dc.title | Effect of thiamine pyrophosphate on ischemia-reperfusion induced oxidative damage in rat kidney | en_US |
dc.type | article | en_US |
dc.contributor.department | RTEÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü | en_US |
dc.contributor.institutionauthor | Altuner, Durdu | |
dc.contributor.institutionauthor | Süleyman, Bahadır | |
dc.contributor.institutionauthor | Suleyman, Halis | |
dc.identifier.doi | 10.4103/0253-7613.115005 | |
dc.identifier.volume | 45 | en_US |
dc.identifier.issue | 4 | en_US |
dc.identifier.startpage | 339 | en_US |
dc.identifier.endpage | 343 | en_US |
dc.ri.edit | oa | en_US |
dc.relation.journal | Indian Journal of Pharmacology | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |