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dc.contributor.authorBostan, Habib
dc.contributor.authorKalkan, Yıldıray
dc.contributor.authorTomak, Yakup
dc.contributor.authorTümkaya, Levent
dc.contributor.authorAltuner, Durdu
dc.contributor.authorYılmaz, Adnan
dc.contributor.authorErdivanlı, Başar
dc.contributor.authorBedir, Recep
dc.date.accessioned2020-12-19T20:10:52Z
dc.date.available2020-12-19T20:10:52Z
dc.date.issued2011
dc.identifier.citationBostan, H., Kalkan, Y., Tomak, Y., Tumkaya, L., Altuner, D., Yılmaz, A., Erdivanli, B., & Bedir, R. (2011). Reversal of rocuronium-induced neuromuscular block with sugammadex and resulting histopathological effects in rat kidneys. Renal failure, 33(10), 1019–1024. https://doi.org/10.3109/0886022X.2011.618972en_US
dc.identifier.issn0886-022X
dc.identifier.urihttps://doi.org/10.3109/0886022X.2011.618972
dc.identifier.urihttps://hdl.handle.net/11436/3595
dc.descriptionPubMed: 22013936en_US
dc.description.abstractBackground: This study investigated the effect of injection of rocuronium or sugammadex alone and rocuronium + sugammadex on urea, creatinine, electrolyte levels, and histopathological findings in rats. Methods: Thirty-six Sprague-Dawley male rats were divided to receive intravenously 16 or 96 mg/kg sugammadex, 1 mg/kg rocuronium, 1 mg/kg rocuronium + 16 mg/kg sugammadex, or 1 mg/kg rocuronium + 96 mg/kg sugammadex. The control group received an equal volume of physiological serum. Rats receiving rocuronium were ventilated until resumption of spontaneous ventilation and followed for 72 h. Blood samples were withdrawn from the tail vein to measure urea, creatinine, and electrolyte values; then both kidneys were excised, and the tissues were used for histopathological examination. Results: Rats receiving rocuronium and high doses of sugammadex (96 mg/kg) showed increased glomerular vacuolation, tubular dilatation, vascular vacuolation and hypertrophy, lymphocyte infiltration, and tubular cell sloughing compared to the control group (p = 0.002). Biochemical markers of renal function were not significantly altered after treatment with high doses of sugammadex. Conclusion: The elimination half-life of the rocuroniumsugammadex complex was found to be greater than that of free rocuronium or sugammadex, which led to marginal histopathological changes in the kidney without affecting any renal functions. © 2011 Informa Healthcare USA, Inc.en_US
dc.description.sponsorshipThis work was supported by all authors with no external funding from a government agency or company. The animals, materials, and drugs were provided by the first author as research fund from his institution (Medical Faculty of Rize University, Department of Anesthesiology and Reanimation).en_US
dc.language.isoengen_US
dc.publisherTaylor & Francisen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectNeuromuscular blocken_US
dc.subjectRaten_US
dc.subjectRocuroniumen_US
dc.subjectSprague-Dawleyen_US
dc.subjectSugammadexen_US
dc.titleReversal of rocuronium-induced neuromuscular block with sugammadex and resulting histopathological effects in rat kidneysen_US
dc.typearticleen_US
dc.contributor.departmentRTEÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.contributor.institutionauthorBostan, Habib
dc.contributor.institutionauthorKalkan, Yıldıray
dc.contributor.institutionauthorTomak, Yakup
dc.contributor.institutionauthorTümkaya, Levent
dc.contributor.institutionauthorAltuner, Durdu
dc.contributor.institutionauthorYılmaz, Adnan
dc.contributor.institutionauthorBedir, Recep
dc.identifier.doi10.3109/0886022X.2011.618972
dc.identifier.volume33en_US
dc.identifier.issue10en_US
dc.identifier.startpage1019en_US
dc.identifier.endpage1024en_US
dc.relation.journalRenal Failureen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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