• Notch and hedgehog signalling axis drive senescence in HER2-positive breast cancer resistant to trastuzumab 

  Boz Er, Asiye Büşra; Er, İdris (Istanbul University Press, 2024)

  Objective: Cellular senescence halts the proliferation of damaged or preneoplastic cells, playing a vital role in cancer control. In HER2-positive breast cancer, resistance to trastuzumab, a HER2-targeted monoclonal antibody, ...

• CDC20 and CCNB1 overexpression as prognostic markers in bladder cancer 

  Nalkıran, Hatice Sevim; Biri, İlknur; Nalkıran, İhsan; Uzun, Hakkı; Durur, Sümeyye; Bedir, Recep (MDPI, 2025)

  Background: Bladder cancer (BC) is one of the ten most common cancers worldwide, with a high recurrence rate and significant variation in clinical outcomes based on tumor grade and stage. This study aimed to investigate ...

• Does radioactive iodine treatment affect thyroid size and tracheal diameter? 

  Yazıcı Demir, Kadriye; Kaya, Zülküf; Dayanan, Ramazan; Mercantepe, Tolga; Mercantepe, Filiz (MDPI, 2025)

  Background/Objectives: There exist three principal treatment modalities employed in the management of hyperthyroidism attributable to excessive hormone secretion by the thyroid gland: antithyroid pharmacotherapy, surgical ...

• Mastectomy, HER2 receptor positivity, NPI, late stage and luminal B-type tumor as poor prognostic factors in geriatric patients with breast cancer 

  Nak, Demet; Kıvrak, Mehmet (MDPI, 2025)

  Background/Objectives: This study aims to explore the risk factors associated with poor survival outcomes in geriatric female patients with breast cancer. Methods: This study utilized data from the METABRIC database to ...

• Type 2 diabetes risk among master swimmers: a case–control study 

  Çelik, Zehra Margot; İslamoğlu, Ayşe Hümeyra; Sabuncular, Güleren; Eren, Fatih; Özüak, Ali; Aktaç, Şule (Springer Nature, 2025)

  Purpose: This study seeks to evaluate the impact of regular physical activity, particularly swimming, on type 2 diabetes (T2DM) risk scores, as measured by the Finnish Diabetes Risk Score (FINDRISC), among competitive ...

• Hi-labspermmorpho: a novel expert-labeled dataset with extensive abnormality classes for deep learning-based sperm morphology analysis 

  Aktaş, Abdulsamet; Serbes, Görkem; Hüner Yiğit, Merve; Aydın, Nizamettin; Uzun, Hakkı; İlhan, Hamza Osman (IEEE, 2024)

  Sperm morphology is crucial in semen analysis for diagnosing male infertility. To reduce limitations in visual assessment, such as variability in biological conditions and the biologist's experience, developing computer-based ...

• White tea reduces dyslipidemia, inflammation, and oxidative stress in the aortic arch in a model of atherosclerosis induced by atherogenic diet in apoe knockout mice 

  Hüner Yiğit, Merve; Atak, Mehtap; Yiğit, Ertuğrul; Topal Suzan, Zehra; Kıvrak, Mehmet; Uydu, Hüseyin Avni (MDPI, 2024)

  Objective: In this study, we aimed to evaluate the potential effects of white tea (WT) in the atherosclerosis process characterized by oxidative stress, inflammation, and dyslipidemia. Methods: In our study, apolipoprotein ...

• Dexmedetomidine improves learning functions in male rats modeling cognitive impairment by modulating the BDNF/TrkB/CREB signaling pathway 

  Saral, Sinan; Mercantepe, Tolga; Topçu, Atilla; Kaya, Ali Koray; Öztürk, Aykut (MDPI, 2024)

  Dexmedetomidine (DEX) is a selective alpha-2 adrenergic receptor agonist with sedative and anxiolytic properties. Increasing evidence reports that DEX has a neuroprotective effect. In this study, we investigated the potential ...

• Effect of white tea on leptin and asprosin levels in rats feeding a high-fat diet 

  Yılmaz, Adnan; Toraman, Merve Nur; Mataracı Karakas, Sibel; Özden, Zülkar; Pınarbaş, Esra; Mercantepe, Tolga (MDPI, 2024)

  Background: Currently, obesity affects over 600 million individuals and is responsible for numerous severe health conditions, particularly diabetes and metabolic syndrome. The objective of our study was to examine the ...

• Rates of PCR positivity of pleural drainage fluid in COVID-19 patients: is it expected? 

  Türüt, Hasan; Özçelik, Neslihan; Çiçek, Ayşegül Çopur; Tuluce, Kerim; Sevilgen, Gökçen; Sakin, Mustafa; Erdivanlı, Başar; Klisic, Aleksandra; Mercantepe, Filiz (MDPI, 2024)

  Background: Tube thoracostomy, utilized through conventional methodologies in the context of pleural disorders such as pleural effusion and pneumothorax, constitutes one of the primary therapeutic interventions. Nonetheless, ...

• Evaluation of serum galectin-3 concentration as a potential biomarker in exudative-type age-related macular degeneration 

  Sümer, Fatma; Subaşı, Sevgi; Bahçeci, İlkay; Satılmaz, Muhammed Fatih (Nature Research, 2024)

  To investigate the effect of serum galectin-3 on naive neovascular AMD and its use as a serum marker by revealing the variation in this molecule between patient and control groups. Fifty-six naive neovascular AMD patients ...

• Assessment of subacute toxicity of ulexite in rats: behavioral, hematological, and biochemical insights 

  Türkez, Hasan; Özdemir Tozlu, Özlem; Yıldız, Edanur; Saraçoğlu, Melik; Baba, Cem; Çınar, Burak; Yıldırım, Serkan; Kılıçlıoğlu, Metin; Topkara, Kübra Çelik; Çadırcı, Kenan (Springer, 2024)

  Ulexite (UX), a naturally occurring borate mineral, has gained interest for its diverse industrial applications, yet its toxicological profile remains inadequately characterized. This study aimed to evaluate the subacute ...

• Clinical and biochemical efficacies of green and white tea extract mouthwashes in the management of plaque-induced gingivitis 

  Köse, Oğuz; Saraç Gül, Yağmur; Bostan, Semih Alperen; Faiz, Özlem; Akyıldız, Kerimali; Yılmaz, Adnan (Wiley, 2024)

  Objective: In this clinical study, chlorhexidine gluconate (CHX) was chosen as the positive control group, and the clinical and biochemical efficacy of mouthwashes with green tea, white tea and essential oil (EO) as the ...

• The impact of the SMOTE method on machine learning and ensemble learning performance results in addressing class imbalance in data used for predicting total testosterone deficiency in type 2 diabetes patients 

  Kıvrak, Mehmet; Avcı, Uğur; Uzun, Hakkı; Ardıç, Cüneyt (MDPI, 2024)

  Background and Objective: Diabetes Mellitus is a long-term, multifaceted metabolic condition that necessitates ongoing medical management. Hypogonadism is a syndrome that is a clinical and/or biochemical indicator of ...

• The correlation between brafv600e expression and integrin β3 in melanoma cells 

  Er, İdris; Boz Er, Asiye Büşra (Academic Publishing House, 2024)

  This study investigated the relationship between ITGB3 and BRAFV600E expression in melanoma. It specifically focused on how the overexpression of BRAFV600E and Integrin β3 impacts wound healing and the TGF-β pathway. The ...

• Preventive effects of melatonin and amifostine on irradiated rats with experimental periodontitis 

  Yorgancılar, Nur; Köse, Oğuz; Rakıcı, Sema Yılmaz; Mercantepe, Tolga; Akyıldız, Kerimali; Tümkaya, Levent; Yılmaz, Adnan (Springer, 2024)

  Background: The aim of this study was to investigate the preventive effects of amifostine and melatonin oxidatively, biochemically and histomorphometrically in rats with radiotherapy-induced experimental periodontitis. ...

• Exposure to a 0.9-GHz electromagnetic field on postnatal days 21–45 may trigger the renin-angiotensin system in male rat: a histological and biochemical study 

  Keleş, Ayşe İkinci; Kaya, Haydar; Keleş, Gökhan; Erol, Hüseyin Serkan; Mercantepe, Tolga; Odacı, Ersan (Springer, 2025)

  The aim of this study was to examine the relationship between the renin-angiotensin system (RAS) and histological and biochemical changes occurring in the kidney tissue of male rats exposed to a 0.9 GHz electromagnetic ...

• Blood pressure patterns and hepatosteatosis: cardiometabolic risk assessment in dipper and non-dipper phenotypes 

  Astan, Ramazan; Patoulias, Dimitrios; Ninić, Ana; Dayanan, Ramazan; Karakasis, Paschalis; Mercantepe, Tolga; Mercantepe, Filiz; Klisic, Aleksandra (MDPI, 2024)

  Background/Objectives: Non-dipper hypertension (HT), a condition in which blood pressure does not drop sufficiently at night compared to daytime, is considered a serious condition that increases the risk of cardiovascular ...

• Antioxidant and anti-proliferative effects of ornithogalum balansae extracts collected in black sea region against lung cancer cells 

  Ejder, Nebahat; Sökmen, Münevver; Tunalı, Fatma; Kolaylı, Sevgi; Kılıç, Ali Osman (MDPI, 2024)

  Ornithogalum is a genus of wild herb species widely used as food and in traditional medicine. This study investigated some of the biologically active properties of Ornithogalum balansae grown in the eastern Black Sea region ...

• Periodontitis provokes retinal neurodegenerative effects of metabolic syndrome: a cross-sectional study 

  Arslan, Hatice; Yorgancılar, Nur; Köse, Oğuz; Aslan, Mehmet Gökhan; Altın, Ahmet; Bayrakdar, Sevda Kurt; Yemenoğlu, Hatice; Fındık, Hüseyin; Yılmaz, Adnan (MDPI, 2024)

  Background: This cross-sectional study aims to investigate the retino-choroidal degenerative effects of periodontitis, metabolic syndrome (Mets), and the combination of these diseases using optical coherence tomography ...

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