• Epithelial barrier hypothesis in the context of nutrition, microbial dysbiosis, and immune dysregulation in metabolic dysfunction-associated steatotic liver 

  Cebi, Merve; Yılmaz, Yusuf (Frontiers Media SA, 2025)

  In recent years, the prevalence of chronic liver diseases, particularly Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD), has increased significantly. This upward trend is largely associated with lifestyle-related ...

• In silico identification of LSD1 inhibition-responsive targets in small cell lung cancer 

  Nalkıran, İhsan; Nalkıran, Hatice Sevim; Özçelik, Neslihan; Kıvrak, Mehmet (MDPI, 2025)

  Small cell lung cancer (SCLC) is an aggressive neuroendocrine malignancy characterized by rapid progression, high metastatic potential, and limited therapeutic options. Lysine-specific demethylase 1 (LSD1) has been identified ...

• Exploring the prevalence and risk factors of MASLD in patients with newly diagnosed diabetes mellitus: a comprehensive investigation 

  Beyazal Polat, Hatice; Beyazal, Mehmet; Arpa, Medeni; Kızılkaya, Bayram; Ayaz, Teslime; Gündoğdu, Ömer Lütfi; Konur, Kamil; Polat, Zehra; Beyazal Çeliker, Fatma (MDPI, 2025)

  Background: Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) represents a growing concern in the context of metabolic disorders, particularly among individuals diagnosed with type 2 diabetes mellitus (T2DM). ...

• Bis(azo-mine) based transition metal complexes: synthesis, spectroscopy, DNA binding, docking studies, and α-glucosidase inhibition activity 

  Zengin, Ali; Ertunga, Nagihan Sağlam; Akatın, Melike Yıldırım; Taşkın Tok, Tuğba; Ghaleb, Abdulmalek Hasan Mohammed; Ejder, Nebahat (John Wiley and Sons Ltd, 2025)

  In this work, two new mononuclear transition metal complexes: [M(L)], (M: Zn(II) for 2a, Mn(II) for 2b), with H2L (2,2′-{propane-1,3-diylbis[nitrilo(E)methylylidene]}bis{4-[(E)-phenyldiazenyl]phenol}, as the primary ligand ...

• Occurrence of antimicrobial resistance, integrons and virulence genes in Escherichia coli isolated from drinking water in Van, Turkiye: a cross-sectional study 

  Rakıcı, Erva; Aydın, Elif; Tanrıverdi, Elif Seren; Özgümüş, Osman Birol (BioMed Central Ltd, 2025)

  Background: Escherichia coli is one of the recommended freshwater indicator organisms for faecal contamination and can be associated with the pool of genes encoding antibiotic resistance. The aim of this study was to ...

• The use of stereological and electron microscopic techniques in the assessment of peripheral nerve regeneration success 

  Delibaş, Burcu (Elsevier, 2025)

  Morphological alterations in nerve tissue are commonly used as a hallmark in evaluating regeneration success in peripheral nerve studies. The use of stereological methods in the assessment of peripheral nerve and ganglion ...

• Metabolite-induced apoptosis by gundelia tournefortii in A549 lung cancer cells: A cytotoxic and gene expression study 

  Yüksel, Aysun; Celayir, Damla Nur; Tunoğlu, Ezgi Nurdan Yenilmez; Tutar, Lütfi; Tutar, Yusuf (MDPI, 2025)

  Background/Objectives: Gundelia tournefortii (Kenger) is a traditional medicinal plant and exhibits potential anticancer properties. This study investigates the cytotoxic and apoptotic effects of its water extract on human ...

• Predicting semen analysis parameters from testicular ultrasonography images using deep learning algorithms: an innovative approach to male infertility diagnosis 

  Sağır, Lütfullah; Kaba, Esat; Hüner Yiğit, Merve; Taşçı, Filiz; Uzun, Hakkı (MDPI, 2025)

  Objectives: Semen analysis is universally regarded as the gold standard for diagnosing male infertility, while ultrasonography plays a vital role as a complementary diagnostic tool. This study aims to assess the effectiveness ...

• The role of 1-Deoxysphingolipids and Polyamines in the pathogenesis of placental syndrome 

  Güleroğlu, Filiz Yarssilikal; Çetin, Ali; Coşkun, Göknil Pelin; Çalışkan, Meltem; Karaduman, Fulya; Bilginer, Can; Mısırlıoğlu, Reşat; Tekin, Sinem; Al, Merve Nur; Çaklılı, Tuğçe; Tutar, Yusuf (BMC, 2025)

  BackgroundPlacental syndrome, mainly composed of preeclampsia and fetal growth restriction, has an impact on the health of mother and baby dyads. While impaired placentation is central to their pathophysiology, the underlying ...

• Role of coagulation factors in hepatocellular carcinoma: a literature review 

  Azam, Azeem; Klisic, Aleksandr; Mercantepe, Filiz; Faseeh, Hamza; Mercantepe, Tolga; Rafaqat, Saira (MDPI, 2025)

  Hepatocyte carcinoma (HCC) is a globally prevalent neoplasm with profound effects on morbidity and mortality rates. This review summarizes the complex interactions between coagulation abnormalities and the pathophysiological ...

• Investigation of ITGB3 heterogeneity to overcome trastuzumab resistance in HER2-positive breast cancer 

  Boz Er, Asiye Büşra (MDPI, 2025)

  HER2-positive breast cancer has an aggressive tumour progression among breast cancers characterized by the overexpression of HER2. Trastuzumab is an FDA-approved drug and has significantly improved outcomes for patients; ...

• Identification and characterization of a novel rat MAVS variant modulating NFκB signaling 

  Nalkıran, İhsan; Nalkıran, Hatice Sevim (MDPI, 2025)

  The innate immune response serves as the primary defense against viral infections, with the recognition of viral nucleic acids by pattern recognition receptors (PRRs) initiating antiviral responses. Mitochondrial ...

• Is punica granatum efficient against sepsis? A comparative study of amifostine versus pomegranate 

  Şahin, Kazım; Şahin Aktura, Sena; Bahçeci, İlkay; Mercantepe, Tolga; Tümkaya, Levent; Topçu, Atilla; Mercantepe, Filiz; Duran, Ömer Faruk; Uydu, Hüseyin Avni; Yazıcı, Zihni Açar (MDPI, 2025)

  Sepsis is a clinical condition causing tissue damage as a result of infection and an exaggerated immune response. Sepsis causes 11 million deaths annually, a third of which are associated with acute lung injury (ALI). Rapid ...

• Evaluation of the effects of low-level laser and steroid therapy, separately or in combination for the treatment of facial nerve injury: An experimental study in rats 

  Gümrükçü, Zeynep; Balaban, Emre; Mercantepe, Tolga; Akyıldız, Kerimali; Doğan, Andaç; Karabağ, Mert; Göksu, Muhammed Raşid; Tümkaya, Levent; Gökçe, Fatih Mehmet; Yılmaz, Adnan (Elsevier, 2025)

  ......

• Investigation of the effects of fosfomycin in kidney damage caused by CLP-induced sepsis 

  Yıldız, İlknur Esen; Mercantepe, Tolga; Bahçeci, İlkay; Arpa, Medeni; Batçık, Şule; Yıldız, Yasin; Tümkaya, Levent (MDPI, 2025)

  Sepsis, a life-threatening condition characterized by dysregulated host responses to infection, often leads to multi-organ dysfunction, including kidney injury. Kidney damage in sepsis can have severe consequences and is ...

• Investigation of the preventive effect of methylsulfonylmethane on alveolar bone loss and oxidative stress in a rat model of periodontitis 

  Beder, Melek; Yemenoğlu, Hatice; Bostan, Semih Alperen; Köse, Oğuz; Karakaş, Sibel Mataracı; Mercantepe, Tolga; Yılmaz, Adnan; Tümkaya, Levent (BMC, 2025)

  Background To investigate the preventive efficacy of methylsulfonylmethane (MSM) on alveolar bone destruction in rats with periodontitis. Methods Twenty-four male Sprague-Dawley rats were randomly divided into three groups: ...

• Effects of 5 G mobile phone network electromagnetic field exposure on testicular endoplasmic reticulum stress and the protective role of coenzyme Q10 

  Yılmaz, Hamit; Tümkaya, Levent; Mercantepe, Tolga; Yılmaz, Adnan; Gül, Fatih; Suzan, Zehra Topal (Elsevier, 2025)

  Aim. Nowadays, the electromagnetic field (EMF) has become an issue of electromagnetic pollution . This study aimed to determine the effect of 5 G Fr1 frequency band EMF waves on endoplasmic reticulum (ER) stress in testicular ...

• Notch and hedgehog signalling axis drive senescence in HER2-positive breast cancer resistant to trastuzumab 

  Boz Er, Asiye Büşra; Er, İdris (Istanbul University Press, 2024)

  Objective: Cellular senescence halts the proliferation of damaged or preneoplastic cells, playing a vital role in cancer control. In HER2-positive breast cancer, resistance to trastuzumab, a HER2-targeted monoclonal antibody, ...

• CDC20 and CCNB1 overexpression as prognostic markers in bladder cancer 

  Nalkıran, Hatice Sevim; Biri, İlknur; Nalkıran, İhsan; Uzun, Hakkı; Durur, Sümeyye; Bedir, Recep (MDPI, 2025)

  Background: Bladder cancer (BC) is one of the ten most common cancers worldwide, with a high recurrence rate and significant variation in clinical outcomes based on tumor grade and stage. This study aimed to investigate ...

• Does radioactive iodine treatment affect thyroid size and tracheal diameter? 

  Yazıcı Demir, Kadriye; Kaya, Zülküf; Dayanan, Ramazan; Mercantepe, Tolga; Mercantepe, Filiz (MDPI, 2025)

  Background/Objectives: There exist three principal treatment modalities employed in the management of hyperthyroidism attributable to excessive hormone secretion by the thyroid gland: antithyroid pharmacotherapy, surgical ...

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