dc.contributor.author | Çokluk, Cengiz | |
dc.contributor.author | Aydın, Kemalettin | |
dc.contributor.author | Tümkaya, Levent | |
dc.date.accessioned | 2020-12-19T20:11:54Z | |
dc.date.available | 2020-12-19T20:11:54Z | |
dc.date.issued | 2010 | |
dc.identifier.citation | Çokluk, C., Aydın, K. & Tümkaya, L. (2010). The effect of omega-3 solution in the prevention of epidural fibrosis formation in experimental rabbit hemilaminotomy model. Journal of Experimental and Clinical Medicine (Turkey), 27(1), 16-19. https://doi.org/10.5835/jecm.omu.27.01.004 | en_US |
dc.identifier.issn | 1300-2996 | |
dc.identifier.uri | https://doi.org/10.5835/jecm.omu.27.01.004 | |
dc.identifier.uri | https://hdl.handle.net/11436/3799 | |
dc.description.abstract | The aim of this experimental study was to evaluate the effect of omega-3 fatty acids solution in the prevention of the forming of peridural fibrotic tissue and adhesion in a rabbit hemilaminotomy model. This new experimental model was previously developed by the first author of this study. Twenty-one New Zealand white rabbits were used for this experiment. Seven of them were randomly selected as Control group and was named as Group I rabbits. The rabbits in this group were not operated and treated. The second group was Group II including 7 rabbits. This group was named as hemilaminotomy and untreated rabbits. Group III included 7 rabbits and named as Omega-3 treated group after hemilaminotomy procedure. In this group (Group III), 250 mg omega-3 solution was put in the hemilaminotomy area before closing the skin and fascia. Four weeks later from the operation rabbits were sacrificied by perfusion with 10% neutral buffered formalin solution. The lumbar spines were removed and immersed in 10% neutral buffered formalin for approximately 24 hours. Then each specimen was decalcified in 5% formic acid for approximately 3 weeks. Specimens were cut coronally for gross inspection. Peridural scar tissue on gross inspection in coronal sectioned specimens was graded into three grades. Grade I epidural scar tissue was scored with 1 point, Grade II with 2 point and Grade III with 3 point. The average score of hemilaminotomy sites without treatment was found as 2, 6 ± 0, 51. In the other hand the average score of hemilaminotomy sites with omega-3 fatty acids treatment was found as 1, 9 ± 0, 56. The difference between the treatment and non-treatment group was statistically significant. Omega-3 fatty acids solution seems an effective treatment modality in the prevention of peridural excessive scar tissue formation in the rabbit hemilaminotomy model. © 2010 OMU All rights reserved. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Ondokuz Mayıs University | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | Fatty acids | en_US |
dc.subject | Hemilaminotomy | en_US |
dc.subject | Lumbar spine | en_US |
dc.subject | Omega-3 | en_US |
dc.subject | Peridural fibrosis | en_US |
dc.subject | Rabbit | en_US |
dc.title | The effect of omega-3 solution in the prevention of epidural fibrosis formation in experimental rabbit hemilaminotomy model | en_US |
dc.type | article | en_US |
dc.contributor.department | RTEÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü | en_US |
dc.contributor.institutionauthor | Tümkaya, Levent | |
dc.identifier.doi | 10.5835/jecm.omu.27.01.004 | |
dc.identifier.volume | 27 | en_US |
dc.identifier.issue | 1 | en_US |
dc.identifier.startpage | 16 | en_US |
dc.identifier.endpage | 19 | en_US |
dc.relation.journal | Journal of Experimental and Clinical Medicine (Turkey) | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |