Determination of the protonation constants of triazole derivatives in non-aqueous solvents

Abstract

Different 17 triazole derivatives were titrated with tetrabutylammonium hydroxide in four non-aqueous solvents (isopropyl alcohol, rert-butyl alcohol, N,N-dimethylformamide and acetonitrile), using Potentiometric method. The half neutralization potential values and the corresponding pKa values were determined for all cases.