FEF, Kimya Bölümü Koleksiyonu
Güncel Gönderiler
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ATM kinase phosphorylates Ser15 of p53 in a pH-dependent manner
(Trakya University, 2024)The phosphorylation of Ser15 in the transactivation domain (TAD) of the tumor suppressor protein 53 (p53) by ataxia-telangiectasia mutated (ATM) kinase is a crucial step in the tumor suppressor function of p53. An understanding ... -
Urease inhibition activity studies of novel azabenzimidazole-derived compounds
(Springer, 2024)AbstractA new series of azabenzimidazole compounds was synthesized and characterized with spectral methods such as IR, 1H NMR, 13C NMR and elemental analysis. The target compounds were screened for urease, and acetylcholinesterase ... -
Theoretical examination of the usability of some benzimidazole derivatives as active pharmaceutical ingredient in the treatment of multiple sclerosis
(Springer, 2024)AbstractIn this study, the usability of twelve different benzimidazole derivatives as active pharmaceutical ingredients in the treatment of multiple sclerosis was investigated. For each molecule, a docking study was carried ... -
Engineered reduction of S-adenosylmethionine alters lignin in sorghum
(BMC, 2024)Background Lignin is an aromatic polymer deposited in secondary cell walls of higher plants to provide strength, rigidity, and hydrophobicity to vascular tissues. Due to its interconnections with cell wall polysaccharides, ... -
Metal-organic frameworks (MOFs) as an anti-reflective coating for crystalline silicon solar cells
(Springer, 2024)Enhancing the performance of the solar cells is a very challenging task and to prevent surface reflections of solar rays is one of the ways. Metal-organic frameworks (MOFs) are novel inorganic-organic crystalline porous ... -
Novel phthalocyanines bearing fluoro-methylquinolin substituents: Synthesis, characterization, photophysical and photochemical properties
(Elsevier, 2024)The novel 4-((6-fluoro-2-methylquinolin-4-yl)oxy)phthalonitrile (3a), 3-((6-fluoro-2-methylquinolin-4-yl)oxy)phthalonitrile (3b), tetra 6-fluoro-2-methylquinolin-4-yl)oxy substituted zinc(II) phthalocyanines (4a and 4b) ... -
Synthesis and characterization of some new 2,3-disubstituted quinazolin-4(3h)-one compounds, investigation of urease, and ache inhibition properties, molecular, and docking study
(Springer, 2024)Objective: Novel 2,3-disubstituted 4-oxoquinazoline-3(4H) derivatives containing oxadiazole, thiazolidinone ring, the 4-oxoquinazoline-3(4H) Schiff bases, and carbothioamide structure were synthesized. All the synthesized ... -
Diversely functionalized benzopyran scaffolds as potential lead candidates for treating Alzheimer's disease and diabetes
(Elsevier, 2024)The current study deals with the preparation of polyfunctional benzopyran derivatives 1–25, synthesized by the condensation of 2,4-dihydroxy benzophenone, substituted aldehydes, and malononitrile. These compounds were ... -
Small steps to the big picture for health-promoting applications through the use of chickweed (stellaria media): in vitro, in silico, and pharmacological network approaches
(Wiley, 2024)Stellaria media L., also called chickweed, is widespread in all parts of the world. In the present study, we investigated the biological properties and chemical profiles of different extracts (ethyl acetate, ethanol, ... -
Fine-tuning the element dose in nanoparticle synthesis is the critical factor determining nanoparticle's impact on plant growth
(Elsevier, 2024)This study elucidates the impact of element dose during nanoparticle (NPs) synthesis on plant growth indices. Novel NPs containing two essential micro-nutrients, zinc (Zn) and manganese (Mn), were co-doped on cerium oxide ... -
Synthesis of novel quinazolinone-triheterocyclic hybrides as dual inhibition of urease and ache
(Springer, 2024)New triheteroyclic compounds containing quinazolinone, thiophene, andthiadiazole /thiazolidinone structureswere synthesized and characterized by FT-IR, 1H–NMR, and13C–NMRspectral data. The new compounds’ inhibitory activities ... -
An inhibition potential on some metabolic enzymes (urease and xanthine oxidase), essential oil contents and antioxidant effect of Sideritis lanata L.
(Springer, 2024)While people use the aerial parts of some Sideritis species as tea and sweetener, some species are used for medicinal purposes. In this study, anti-urease, anti-xanthine oxidase, and antioxidant activity of Sideritis lanata ... -
New metallophthalocyanine (M: Ni(II) and Fe(II)) complexes as efficient catalysts for transfer hydrogenation of various ketones
(Elsevier, 2024)Hydrogen transfer reduction methods are attracting increasing attention from synthetic chemists in view of their operational simplicity. Therefore, the novel Ni(II) and Fe(II) tetra substituted metallophthalocyanines ... -
Microplastics in honey from Türkiye: Occurrence, characteristic, human exposure, and risk assessment
(Elsevier, 2024)In this study, honey samples produced in Türkiye in 2023 were analyzed to assess occurrence of microplastics. The microplastics were physically and chemically characterised by stereomicroscope and FT-IR, respectively. ... -
Design, synthesis, molecular modeling, in vitro evaluation of novel piperidine-containing hydrazone derivatives as cholinesterase inhibitors
(Wiley, 2024)In an effort to develop new and effective therapeutic agents for Alzheimer's disease, a series of hydrazone derivatives bearing piperidine rings have been designed and synthesized. The chemical structures of the compounds ... -
Synthesis and anticancer activities of amide-bridged coumarin–quinazolinone hybrid compounds
(Springer, 2024)Abstract: Some novel 3-aminoquinazolin-4(3H)-one derivatives were synthesized by the reaction of 2-aminobenzhydrazide and corresponding iminoester hydrochlorides and then reacted with coumarin-3-carbonyl chloride to obtain ... -
An investigation of fastness and potential antibacterial features on cotton fabric colored with novel azo compounds
(Sage Publications, 2024)Novel azo compounds were synthesized by diazotization of aniline and of 3-aminopyridine in the presence of NaNO2 and HCl, followed by coupling with 2-methylresorcinol in alkaline media. The structures were characterized ... -
Expression in poplar of dehydroshikimate dehydratase induces transcriptional and metabolic changes in the phenylpropanoid pathway
(Oxford Academic, 2024)Modification of lignin in feedstocks via genetic engineering aims to reduce biomass recalcitrance to facilitate efficient conversion processes. These improvements can be achieved by expressing exogenous enzymes that interfere ... -
Imidazole-thiadiazole hybrids: A multitarget de novo drug design approach, in vitro evaluation, ADME/T, and in silico studies
(Wiley, 2024)A library of imidazole-thiadiazole compounds (1–24) was synthesized to explore their therapeutic applications. The compounds were subjected to meticulous in vitro evaluation against α-glucosidase, α-amylase, acetylcholinesterase ... -
A novel Schiff base-containing phthalocyanine and its azo dye-substituted analogue: The effect of pH on colour
(CSIRO, 2024)There are many studies in the literature devoted to the synthesis of phthalocyanines substituted with Schiff bases and azo dyes and their particular properties. However, the comparison of spectral properties of these ...
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