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Microwave-assisted synthesis of 4?-azaflavones and their n-alkyl derivatives with biological activities

Access

info:eu-repo/semantics/closedAccess

Date

2008

Author

Yaşar, A.
Akapinar, K.
Burnaz, N.A.
Küçük, M.
Karaoğlu, S.A.
Doğan, N.
Yayh, N.

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Abstract

4?-Azaflavone (=2-(pyridin-4-yl)-4H-1-benzopyran-4-one; 4) and 3-[(pyridin-4-yl)methyl]-4?-azaflavone (5) were synthesized by a simple environmentally friendly microwave-assisted one-pot method through the cyclization of 3-hydroxy-1-(2-hydroxyphenyl)-3-(pyridin-4-yl)propan-1-one (1), (E)-2?-hydroxy-4-azachalcone (2; chalcone=1,3-diphenylprop-2-en-1-one), and 2?-hydroxy-2-[(hydroxy)(pyridin-4-yl)methyl]-4?-azachalcone (3) under solventless conditions using silica-supported NaHSO4, followed by treatment with base. In addition, N-alkyl-substituted 4?-azaflavonium bromides 6 and 7 were prepared from compounds 4 and 5, respectively. The antimicrobial and antioxidant activities of compounds 1-7 were tested. The N-alkyl-substituted 4?-azaflavonium bromides 6 and 7 showed high antimicrobial activity against the Gram-positive bacteria and the fungus tested, with MIC values close to those of reference antimicrobials ampicilline and fluconazole. The alkylated compounds 6 and 7 also showed a good antioxidant character in the two antioxidant methods, DPPH (=1,1-diphenyl-2-picrylhydrazyl) radical-scavenging and ferric reducing/ antioxidant power (FRAP) tests. © 2008 Verlag Helvetica Chimica Acta AG, Zürich.

Source

Chemistry and Biodiversity

Volume

5

Issue

5

URI

https://doi.org/10.1002/cbdv.200890078
https://hdl.handle.net/11436/3900

Collections

  • Scopus İndeksli Yayınlar Koleksiyonu [3511]



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