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dc.contributor.authorBekircan, Olcay
dc.contributor.authorKahveci, Bahittin
dc.contributor.authorÖzgümüş, Osman Birol
dc.date.accessioned2020-12-19T20:12:57Z
dc.date.available2020-12-19T20:12:57Z
dc.date.issued2007
dc.identifier.citationBekircan, O., Kahveci, B. & Özgümüş, B. (2007). Synthesis of Some N-Alkoxycarbonyl-N"-benzoyl-benzamidr-azones(p-toluamidrazones) and 1,3,5-Trisubstituted 1,2,4-Triazole Derivatives from N-Benzoylimidates and their Antimicrobial and Anticancer Screening Studies. Chinese Journal of Chemistry, 25(12), 1871-1877. http://doi.org/10.1002/cjoc.200790345en_US
dc.identifier.issn1001-604X
dc.identifier.urihttps://doi.org/10.1002/cjoc.200790345
dc.identifier.urihttps://hdl.handle.net/11436/3955
dc.description.abstractSome new N-alkoxycarbonyl-N?-benzoyl-benzamidrazones (p-toluamidrazones) 3a-3d, and 1,3,5-trisubstituted 1,2,4-triazole 4a-4h derivatives by starting from N-benzoylbenzimidates or N-benzoyl-p-toluimidates. The structures of compounds 3 and 4 were established on the basis of elemental analyses, IR, 1H NMR, 13C NMR and UV data. Antimicrobial experiments of the compounds performed by using agar-well diffusion and broth microdilution methods revealed that only compounds 3a-3d, 4a and 4b showed inhibitory effect only on Candida albicans ATCC 60193. However, compound 4b had also specific antibacterial activity against Staphylococcus aureus ATCC 25923. The other compounds showed neither antifungal nor antibacterial activities. Compounds 3a, 4a and 4b have been screened on three human tumor cell lines, breast cancer (MCF7), non small cell lung cancer (NCI-H460), and CNS cancer (SF-268) at the National Cancer Institute (NCI), USA, which were found to exhibit low antiproliferative activity. © 2007 SIOC, CAS, & Wiley-VCH Verlag GmbH & Co. KGaA.en_US
dc.language.isoengen_US
dc.publisherWileyen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subject1,2,4-triazolesen_US
dc.subjectAnticancer activityen_US
dc.subjectAntimicrobial activityen_US
dc.subjectCarbonylhydrazoneen_US
dc.subjectN-acylimidatesen_US
dc.titleSynthesis of some N-alkoxycarbonyl-N"-benzoyl-benzamidrazones(p- toluamidrazones) and 1,3,5-trisubstituted 1,2,4-triazole derivatives from N-benzoylimidates and their antimicrobial and anticancer screening studiesen_US
dc.typearticleen_US
dc.contributor.departmentRTEÜ, Fen - Edebiyat Fakültesi, Biyoloji Bölümüen_US
dc.contributor.institutionauthorKahveci, Bahittin
dc.contributor.institutionauthorÖzgümüş, Osman Birol
dc.identifier.doi10.1002/cjoc.200790345
dc.identifier.volume25en_US
dc.identifier.issue12en_US
dc.identifier.startpage1871en_US
dc.identifier.endpage1877en_US
dc.relation.journalChinese Journal of Chemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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