A study on 4-acylamino-4,5-dihydro-1H-1,2,4-triazol-5-ones
Künye
Alkan, M., Yüksek, H., Islamoğlu, F., Bahçeci, S., Calapoğlu, M., Elmastaş, M., Akşit, H., & Ozdemir, M. (2007). A study on 4-acylamino-4,5-dihydro-1H-1,2,4-triazol-5-ones. Molecules (Basel, Switzerland), 12(8), 1805–1816. https://doi.org/10.3390/12081805Özet
Five novel 3-alkyl-4-phenylacetylamino-4,5-dihydro-1H-1,2,4-triazol-5-ones (2) were synthesized by the reactions of 3-alkyl-4-amino-4,5-dihydro-1H-1,2,4- triazol-5-ones (1) with phenylacetyl chloride and characterized by elemental analyses and IR, 1H-NMR, 13C-NMR and UV spectral data. The newly synthesized compounds 2 were titrated potentiometrically with tetrabutylammonium hydroxide in four non-aqueous solvents such as isopropyl alcohol, tert-butyl alcohol, acetonitrile and N,N-dimethylformamide, and the half-neutralization potential values and the corresponding pKa values were determined for all cases. In addition, these new compounds and five recently reported 3-alkyl-4-(p-methoxybenzoylamino)-4,5-dihydro-1H-1,2,4- triazol-5-ones (3) were screened for their antioxidant activities. © 2007 by MDPI.
