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dc.contributor.authorTomak, Yakup
dc.contributor.authorYılmaz, Adnan
dc.contributor.authorBostan, Habib
dc.contributor.authorTümkaya, Levent
dc.contributor.authorAltuner, Durdu
dc.contributor.authorKalkan, Yıldıray
dc.contributor.authorErdivablı, Başar
dc.date.accessioned2020-12-19T20:16:25Z
dc.date.available2020-12-19T20:16:25Z
dc.date.issued2012
dc.identifier.citationTomak, Y., Yılmaz, A., Bostan, H., Tümkaya, L., Altuner, D., Kalkan, Y., & Erdivanlı, B. (2012). Effects of sugammadex and rocuronium mast cell number and degranulation in rat liver. Anaesthesia, 67(10), 1101–1104. https://doi.org/10.1111/j.1365-2044.2012.07264.xen_US
dc.identifier.issn0003-2409
dc.identifier.urihttps://doi.org/10.1111/j.1365-2044.2012.07264.x
dc.identifier.urihttps://hdl.handle.net/11436/4193
dc.descriptionPubMed: 22827538en_US
dc.description.abstractWe investigated the effect of rocuronium- and sugammadex-induced mast cell increase and degranulation in rat portal triads. Forty-two rats, in six groups, received either rocuronium 1 mg.kg -1; sugammadex 15 mg.kg -1; sugammadex 100 mg.kg -1; rocuronium 1 mg.kg -1 and 5 min later, sugammadex 15 mg.kg -1; rocuronium 1 mg.kg -1 and 5 min later, sugammadex 100 mg.kg -1; or isotonic saline. Total mast cell numbers were significantly higher with rocuronium only, than in all other groups (p < 0.003), although in all active groups, the number was greater than the control. Total mast cell number was significantly higher with rocuronium and low-dose sugammadex compared with low-dose sugammadex only. The number of tryptase-positive mast cells with rocuronium only was significantly higher than in all other groups (p < 0.003). Tryptase-positive mast cell numbers in both groups receiving both rocuronium and sugammadex were significantly higher compared with both groups receiving sugammadex only. Rocuronium increased mast cell numbers, and degranulation was mitigated by sugammadex. These results suggest that sugammadex may be beneficial in treatment of rocuronium-induced anaphylaxis. © Anaesthesia © 2012 The Association of Anaesthetists of Great Britain and Ireland.en_US
dc.language.isoengen_US
dc.publisherWileyen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.titleEffects of sugammadex and rocuronium mast cell number and degranulation in rat liveren_US
dc.typearticleen_US
dc.contributor.departmentRTEÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.contributor.institutionauthorTomak, Yakup
dc.contributor.institutionauthorYılmaz, Adnan
dc.contributor.institutionauthorBostan, Habib
dc.contributor.institutionauthorTümkaya, Levent
dc.contributor.institutionauthorAltuner, Durdu
dc.contributor.institutionauthorKalkan, Yıldıray
dc.contributor.institutionauthorErdivanlı, Başar
dc.identifier.doi10.1111/j.1365-2044.2012.07264.x
dc.identifier.volume67en_US
dc.identifier.issue10en_US
dc.identifier.startpage1101en_US
dc.identifier.endpage1104en_US
dc.relation.journalAnaesthesiaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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