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dc.contributor.authorBodur, Akın
dc.contributor.authorKahraman, Cemil
dc.contributor.authorAltay, Diler Us
dc.contributor.authorRendı, Taghi Ahmadi
dc.contributor.authorMenteşe, Ahmet
dc.contributor.authorAlver, Ahmet
dc.date.accessioned2020-12-19T20:24:55Z
dc.date.available2020-12-19T20:24:55Z
dc.date.issued2018
dc.identifier.citationBodur, A., Kahraman, C., Us Altay, D., Rendi, T. A., Menteşe, A., & Alver, A. (2018). Investigation of the relationship between oxidative stress and SCUBE1 levels in high fat diet-induced obese rats. Turkish journal of medical sciences, 48(1), 196–201. https://doi.org/10.3906/sag-1709-160en_US
dc.identifier.issn1300-0144
dc.identifier.issn1303-6165
dc.identifier.urihttps://doi.org/10.3906/sag-1709-160
dc.identifier.urihttps://app.trdizin.gov.tr/makale/TWprNU1UYzVPUT09
dc.identifier.urihttps://hdl.handle.net/11436/4928
dc.description.abstractBackground/aim: This study aimed to investigate signal peptide-Cub-EGF domain-containing protein 1 (SCUBE1) levels and oxidative stress (OS) in a high fat diet (HFD)-induced obese rat model. Materials and methods: Fourteen rats were randomly divided into two groups. Group 1, the control group, was given a standard diet (10% calories of fat) and Group 2, the obese group, was given a HFD (60% calories of fat), both for 70 days. Rats were then sacrificed and serum samples were collected. Serum glucose and triglyceride concentrations were determined using an autoanalyzer. Serum SCUBE1, adiponectin, and plasminogen activator inhibitor-1 levels were determined using an enzyme-linked immunosorbent assay. Serum malondialdehyde levels and superoxide dismutase and glutathione peroxidase enzyme activities were determined using colorimetric methods. Results: Final body weight was higher in the obese group (P = 0.007). Serum malondialdehyde concentrations were also higher in the obese group (P = 0.021). Serum glutathione peroxidase activities were higher in the control group (P = 0.028). Serum SCUBE1 levels were also higher in the control group (P = 0.038). Conclusion: There may be no connection between the measured OS parameters and SCUBE1. Differences in SCUBE1 levels may therefore be evaluated independently from OS in obesityen_US
dc.language.isoengen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCerrahien_US
dc.subjectHigh fat dieten_US
dc.subjectLipid peroxidationen_US
dc.subjectOxidative stressen_US
dc.subjectObesityen_US
dc.subjectSCUBE1en_US
dc.titleInvestigation of the relationship between oxidative stress and SCUBE1 levels in high fat diet-induced obese ratsen_US
dc.typearticleen_US
dc.contributor.departmentRTEÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.contributor.institutionauthorAlver, Ahmet
dc.identifier.doi10.3906/sag-1709-160
dc.identifier.volume48en_US
dc.identifier.issue1en_US
dc.identifier.startpage196en_US
dc.identifier.endpage201en_US
dc.ri.editoaen_US
dc.relation.journalTurkish Journal of Medical Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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