Synthesis of some new benzimidazole derivatives containing chlorine and investigation of their antioxidant and anti-urease activities

Abstract

In this work, the synthesis of a 2-substituted benzimidazole compound containing chlorine (1) was carried out and then converted to the ester (2) and hydrazide (3) derivatives respectively. In the next steps, the hydrazide compound (3) was reacted with the appropriate reagents to give the thiadiazole (8- 10) and triazole (11-13) derivatives. Synthesis of the compound 4 was carried out as a result of the interaction of the ester derivative compound (2) with morpholine. The structures of all new synthesized compounds were determined by FT-IR, 1H NMR, 13C NMR and elemental analysis spectroscopic methods. Also, the antioxidant and urease enzyme inhibition properties of these compounds were also investigated.