dc.contributor.author | Yılmaz, Yusuf | |
dc.contributor.author | Toraman, Ahmet Eren | |
dc.contributor.author | Alp, Ceyda | |
dc.contributor.author | Doğan, Zehra | |
dc.contributor.author | Keklikkıran, Çağlayan | |
dc.contributor.author | Stepanova, Maria | |
dc.contributor.author | Younossi, Zobair | |
dc.date.accessioned | 2022-11-30T10:26:22Z | |
dc.date.available | 2022-11-30T10:26:22Z | |
dc.date.issued | 2022 | en_US |
dc.identifier.citation | Yilmaz, Y., Toraman, A. E., Alp, C., Doğan, Z., Keklikkiran, C., Stepanova, M., & Younossi, Z. (2022). Impairment of patient-reported outcomes among patients with non-alcoholic fatty liver disease: a registry-based study. Alimentary pharmacology & therapeutics, 10.1111/apt.17301. Advance online publication. https://doi.org/10.1111/apt.17301 | en_US |
dc.identifier.issn | 0269-2813 | |
dc.identifier.issn | 1365-2036 | |
dc.identifier.uri | https://doi.org/10.1111/apt.17301 | |
dc.identifier.uri | https://hdl.handle.net/11436/7198 | |
dc.description.abstract | Background Patients with non-alcoholic fatty liver disease (NAFLD) and more advanced fibrosis tend to have more impairment in their health-related quality of life and other patient-reported outcomes (PROs). Aim To assess the association of PROs with select non-invasive tests (NITs) for fibrosis including FAST, Agile 3+ and Agile 4 scores Methods We enrolled patients with an established diagnosis of NAFLD who were seen in a tertiary care clinic into the NAFLD/NASH Registry. The FAST, Agile 3+ and Agile 4 scores were calculated using liver stiffness measurements by transient elastography and laboratory parameters. PROs were assessed using FACIT-F, CLDQ-NASH and WPAI instruments (total of 17 domain and summary scores). Results There were 1509 patients with NAFLD (mean age: 49 +/- 11 years, 50% men, 41% employed, 30% advanced fibrosis and 20% cirrhosis). The mean FAST, Agile 3+ and Agile 4 scores were 0.39 +/- 0.26, 0.35 +/- 0.31 and 0.12 +/- 0.23, respectively. Subjects with lower FAST, Agile 3+ and Agile 4 scores had the highest scores in select domains of FACIT-F, CLDQ-NASH and WPAI (p < 0.05 in comparison to subjects with elevated or high-risk NIT scores). Correlations with continuous NITs were significantly negative for Emotional and Functional well-being (FACIT-F), Activity/energy, Systemic symptoms, Worry and total scores (CLDQ-NASH), and Activity of WPAI (p < 0.05); the strongest was for Worry (CLDQ-NASH) with FAST (R = -0.17, p < 0.0001). The PRO scores of patients with NAFLD were lower than those of matched patients with chronic hepatitis B (p < 0.05 for 9/17 domain and summary scores). Conclusion Patients with NAFLD and high FAST, Agile 3+ or Agile 4 scores experience impairment of health-related quality of life. | en_US |
dc.language.iso | ara | en_US |
dc.publisher | Wiley | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Quality-of-life | en_US |
dc.subject | Transient elastography | en_US |
dc.title | Impairment of patient-reported outcomes among patients with non-alcoholic fatty liver disease: a registry-based study | en_US |
dc.type | article | en_US |
dc.contributor.department | RTEÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü | en_US |
dc.contributor.institutionauthor | Yılmaz, Yusuf | |
dc.contributor.institutionauthor | Keklikkıran, Çağlayan | |
dc.identifier.doi | 10.1111/apt.17301 | en_US |
dc.relation.journal | Alimentary Pharmacology & Therapeutics | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |