Angiomyofibroblastoma of the lower genital tract of women: Report of two cases

Abstract

Superficial angiomyofibroblastoma of the lower genital tract of women is a very rare, benign neoplasm that most commonly arises in the vulvo-vaginal area. Our first case is a 45-year-old woman who presented with menometrorrhagia. On gynecological examination, a pedinculated polipoid mass 2.5 cm in size was found on the cervix. The second case is a 40-year-old woman presented with a nodular mass 5 cm in size on the vulva. She admitted to hospital with itching and cosmetic problems. Histologic examination revealed bland spindled and epithelioid cells arranged around blood vessels. Tumor cells have immunoreactivity for desmin, vimentin, estrogen and progesterone receptors but staining for cytokeratin was negative. In the lipomatous variant, the cells are dispersed into the adipose tissue. Differential diagnosis of lipomatous angiomyofibroblastoma includes; spindle cell lipoma, angiomyolipoma, and cellular angiofibroma. We will discuss the differential diagnosis of these cases with immunohistochemical and morphological findings.