dc.contributor.author | Emirik, Mustafa | |
dc.date.accessioned | 2022-12-12T08:25:29Z | |
dc.date.available | 2022-12-12T08:25:29Z | |
dc.date.issued | 2021 | en_US |
dc.identifier.citation | Emirik, M. (2021). In silico inhibition potential of artemisinin derivatives against sars-cov-2 main protease. El-Cezeri Journal of Science and Engineering, 8(2), 809-816. https://doi.org/10.31202/ecjse.894617 | en_US |
dc.identifier.issn | 2148-3736 | |
dc.identifier.uri | https://doi.org/10.31202/ecjse.894617 | |
dc.identifier.uri | https://hdl.handle.net/11436/7266 | |
dc.description.abstract | The outbreak of COVID-19 caused by the SARS-CoV-2 virus has recently affected millions worldwide. The natural compounds obtained from medicinal plants have been proven to be the source of many treatments throughout history. Efforts to combat Sars-CoV-2 generally focused on repositioning drugs or finding treatments with natural compounds and have been rapidly ongoing. Main protease (Mpro) is a vital protein of SARS-CoV-2 and an important target of drug research. The present study evaluated seven artemisinin derivatives: artemisinin, artemether, arteether, artesunate, dihydroartemisinic acid, dihydroartemisinin and artemisinic acid. For this purpose, the molecular docking study was carried out to investigate the potency of artemisinin derivatives against the SARS-CoV-2 Mpro. As a result, artesunate, dihydroartemisinic acid and dihydroartemisinin had promising results in Mpro inhibition with the binding energies between-8.42 and-9.35 kcal/mol. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | TUBİTAK Scientific & Technical Research Council Turkey | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | Artemisinin | en_US |
dc.subject | Artesunate | en_US |
dc.subject | COVID-19 | en_US |
dc.subject | Main protease | en_US |
dc.title | In silico inhibition potential of artemisinin derivatives against SARS-CoV-2 main protease | en_US |
dc.title.alternative | Artemisinin türevi bileşiklerin SARS-CoV-2 ana proteaz proteinine karşı in silico inhibisyon potansiyeli | en_US |
dc.type | article | en_US |
dc.contributor.department | RTEÜ, Fen - Edebiyat Fakültesi, Kimya Bölümü | en_US |
dc.contributor.institutionauthor | Emirik, Mustafa | |
dc.identifier.doi | 10.31202/ecjse.894617 | en_US |
dc.identifier.volume | 8 | en_US |
dc.identifier.issue | 2 | en_US |
dc.identifier.startpage | 809 | en_US |
dc.identifier.endpage | 816 | en_US |
dc.relation.journal | El-Cezeri Journal of Science and Engineering | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |