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GLUT-1 expression in breast cancer

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info:eu-repo/semantics/openAccess

Date

2022

Author

Okcu, Oğuzhan
Şen, Bayram
Öztürk, Çiğdem
Güvendi, Gülname Fındık
Bedir, Recep

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Okcu, O., Sen, B., Ozturk, C., Guvendi, G. F., & Bedir, R. (2022). GLUT-1 Expression in Breast Cancer. GLUT-1 Expression in Breast Cancer. Turk patoloji dergisi, 38(2), 114–121. https://doi.org/10.5146/tjpath.2021.01557

Abstract

Objective: Numerous studies have been conducted to predict the prognosis of breast cancers. The effect of glucose transporter protein 1 (GLUT-1), the main carrier protein responsible for glucose transport, was investigated in breast cancer patients. Material and Method: 170 patients operated for breast carcinoma were included in this study. We analysed the prognostic significance of GLUT-1 immune-expression in 149 patients without neoadjuvant therapy, and in 21 patients with neoadjuvant therapy. Results: GLUT-1 expression was correlated with poor prognostic factors such as estrogen receptor and progesterone receptor negativity, high Ki-67 proliferation index, and high histological and nuclear grade (p<0.001). GLUT-1 was expressed at a statistically higher rate in invasive ductal carcinomas, compared to invasive lobular carcinomas (p <0.001), and was expressed at a higher rate in luminal B, human epidermal growth factor receptor 2 and triple-negative molecular subtypes compared to luminal A subtype tumors (p <0.001). There was no statistically significant difference between GLUT-1 expression and presence of neoadjuvant therapy. Univariate survival analysis showed high GLUT1 expression was associated with low disease-free survival. Conclusion: GLUT-1 expression was found to be associated with poor pathological prognostic factors in breast carcinoma patients. The results suggest that GLUT-1 expression can be considered as a prognostic marker in breast cancers, and it may be used as a target molecule in personalized treatment approaches.

Source

Türk Patoloji Dergisi

Volume

38

Issue

2

URI

https://doi.org/10.5146/tjpath.2021.01557
https://hdl.handle.net/11436/7397

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  • PubMed İndeksli Yayınlar Koleksiyonu [2443]
  • Scopus İndeksli Yayınlar Koleksiyonu [6023]
  • TF, Cerrahi Tıp Bilimleri Bölümü Koleksiyonu [1224]
  • TF, Temel Tıp Bilimleri Bölümü Koleksiyonu [700]
  • TR-Dizin İndeksli Yayınlar Koleksiyonu [2844]



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