The relationship of serum asymmetric dimethylarginine concentrations and lung involvement in patients with COVID-19 infection
![Thumbnail](/xmlui/bitstream/handle/11436/7611/emlek--2021.pdf.jpg?sequence=4&isAllowed=y)
View/ Open
Access
info:eu-repo/semantics/openAccessDate
2021Author
Emlek, NadirYılmaz, Ahmet Seyda
Ergül, Elif
Gündoğdu, Hasan
Arpa, Medeni
Koç, Haldun
Öztürk, Muhammet
Aydın, Cihan
Metadata
Show full item recordCitation
Emlek, N., Yılmaz, A.S., Ergül, E., Gündoğdu, H., Arpa, M., Koç, H., Öztürk, M. & Aydın, C. (2021). The relationship of serum asymmetric dimethylarginine concentrations and lunginvolvement in patients with COVID-19 infection. Experimental Biomedical Research, 4(4), 314-321. http://doi.org/10.30714/j-ebr.2021471926Abstract
Aim: COVID-19 infections the tissue through angiotensin converting enzyme 2 receptor, which is also
expressed on endothelial cells. Endothelial dysfunction may be associated with lung involvement. Asymmetric
dimethylarginine (ADMA) is an indirect marker of endothelial dysfunction. The aim of our study was to
evaluate ADMA concentrations and to identify its association with lung involvement in patients with COVID19 disease.
Methods: We included 42 patients with COVID-19 infection and lung involvement (Group 1). Forty-two age
and sex matched patients without pneumonia acted as the control group (Group 2). All patients gave blood
samples for ADMA at the 1st month control visit after discharge. We compared C-reactive protein (CRP) and
ADMA concentrations in addition to routine biochemical parameters between groups.
Results: Patients with lung involvement had higher admission glucose, CRP, and ADMA concentrations, and
displayed lower hemoglobin concentration and lymphocyte count compared to patients without lung
involvement. Although patients with lung involvement had higher ADMA concentrations with respect to those
without; plasma ADMA levels were also higher than normal values in control group. Multivariate analysis
identified log CRP concentration (OR= 3.047, 95% CI=1.881-5.023, p<0.001) as the independent predictor
for lung involvement. And, there was a correlation between ADMA and CRP (r: 0.318, p: 0.003).
Conclusion: We revealed elevated ADMA concentrations as the surrogate of endothelial dysfunction in
COVID-19 patients whether they have pneumonia or not.