Dihydroisocoumarins and phenylglycosides from scorzonera longiana, their antimicrobial activities and molecular docking studies
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Erişim
info:eu-repo/semantics/closedAccessTarih
2023Yazar
Korkmaz, BüşraRenda, Gülin
Bozdal, Gözde
Coşkunçelebi, Kamil
Bozdeveci, Arif
Uzuner, Uğur
Yaylı, Nurettin
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Korkmaz, B., Renda, G., Bozdal, G., Coşkunçelebi, K., Bozdeveci, A., Uzuner, U., & Yaylı, N. (2023). Dihydroisocoumarins and Phenylglycosides from Scorzonera longiana, Their Antimicrobial Activities and Molecular Docking Studies. Chemistry & biodiversity, 20(4), e202201052. https://doi.org/10.1002/cbdv.202201052Özet
Five new phenyl dihydroisocoumarin glycosides (1-5) and two known compounds (6-7) were identified from the butanol fraction of Scorzonera longiana. The structures of 1-7 were elucidated based on spectroscopic methods. Antimicrobial, antitubercular, and antifungal evaluation of compounds 1-7 were carried out using the microdilution method against nine microorganisms. Compound 1 was active only against Mycobacterium smegmatis (Ms) with a MIC value of 14.84 mu g/mL. All tested compounds (1-7) were active against Ms but only compounds 3-7 were active against fungi (C. albicans, S. cerevisiae) with MIC values of 25.0-125 mu g/mL. In addition, molecular docking studies were conducted against Ms DprE1 (PDB ID: 4F4Q), Mycobacterium tuberculosis (Mbt) DprE1 (PDB ID: 6HEZ), and arabinosyltransferase C (EmbC, PDB ID: 7BVE) enzymes. Compounds 2, 5, and 7 are the most effective Ms 4F4Q inhibitors. Compound 4 was the most promising inhibitory activity on Mbt DprE with the lowest binding energy of -9,9 kcal/mol.