| dc.contributor.author | Demir, Elif Ayazoğlu | |
| dc.contributor.author | Menteşe, Ahmet | |
| dc.contributor.author | Livaoğlu, Ayten | |
| dc.contributor.author | Alemdar, Nihal Türkmen | |
| dc.contributor.author | Aliyazıcıoğlu, Yüksel | |
| dc.contributor.author | Demir, Selim | |
| dc.date.accessioned | 2023-09-06T06:19:24Z | |
| dc.date.available | 2023-09-06T06:19:24Z | |
| dc.date.issued | 2023 | en_US |
| dc.identifier.citation | Ayazoglu Demir, E., Mentese, A., Livaoglu, A., Turkmen Alemdar, N., Aliyazicioglu, Y., & Demir, S. (2023). Chlorogenic acid attenuates cisplatin-induced ovarian injury in rats. Drug and chemical toxicology, 1–5. Advance online publication. https://doi.org/10.1080/01480545.2023.2172181 | en_US |
| dc.identifier.issn | 0148-0545 | |
| dc.identifier.issn | 1525-6014 | |
| dc.identifier.uri | https://doi.org/10.1080/01480545.2023.2172181 | |
| dc.identifier.uri | https://hdl.handle.net/11436/8261 | |
| dc.description.abstract | The aim of this study was to determine the possible therapeutic effect of chlorogenic acid (CGA) on cisplatin (CDDP)-induced ovarian damage in rats. Rats were first exposed to CDDP (5 mg/kg) and then treated CGA (1.5 and 3 mg/kg) for three days. Oxidative stress (OS), inflammation and apoptosis markers were determined using spectrophotometric methods. Ovarian tissues were also evaluated histologically. The levels of OS, inflammation and apoptosis biomarkers increased by CDDP administration (p < 0.05). Treatments with CGA significantly alleviated these markers dose-dependently (p < 0.05). These data reveal that CGA may exert an ovoprotective effect by reducing pro-inflammatory mediators and enhancing antioxidant status in ovarian tissue. | en_US |
| dc.language.iso | eng | en_US |
| dc.publisher | Taylor & Francis Ltd. | en_US |
| dc.rights | info:eu-repo/semantics/closedAccess | en_US |
| dc.subject | Apoptosis | en_US |
| dc.subject | Chlorogenic acid | en_US |
| dc.subject | Cisplatin | en_US |
| dc.subject | Inflammation | en_US |
| dc.subject | Ovarian damage | en_US |
| dc.subject | Oxidative stress | en_US |
| dc.title | Chlorogenic acid attenuates cisplatin-induced ovarian injury in rats | en_US |
| dc.type | article | en_US |
| dc.contributor.department | RTEÜ, Sağlık Hizmetleri Meslek Yüksekokulu, Tıbbi Hizmetler ve Teknikler Bölümü | en_US |
| dc.contributor.institutionauthor | Alemdar, Nihal Türkmen | |
| dc.identifier.doi | 10.1080/01480545.2023.2172181 | en_US |
| dc.relation.journal | Drug and Chemical Toxicology | en_US |
| dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
