dc.contributor.author | Younossi, Zobair M. | |
dc.contributor.author | Yu, Ming-Lung | |
dc.contributor.author | Yılmaz, Yusuf | |
dc.contributor.author | Alswat, Khalid Aida | |
dc.contributor.author | Buti, Maria | |
dc.contributor.author | Fernandez, Marlen Ivon Castellanos | |
dc.contributor.author | Papatheodoridis, Georgios | |
dc.contributor.author | Hamid, Saeed S. | |
dc.contributor.author | El-Kassas, Mohamed | |
dc.contributor.author | Chan, Wah Kheong | |
dc.contributor.author | Duseja, Ajay K. | |
dc.contributor.author | Gordon, Stuart C. | |
dc.contributor.author | Eguchi, Yuichiro | |
dc.contributor.author | Isakov, Vasily A. | |
dc.contributor.author | Roberts, Stuart K. | |
dc.contributor.author | Fan, Jian-Gao | |
dc.contributor.author | Singal, Ashwani K. | |
dc.contributor.author | Romero-Gomez, Manuel | |
dc.contributor.author | Ahmed, Aijaz | |
dc.contributor.author | Ong, Janus | |
dc.contributor.author | Lam, Brian P. | |
dc.contributor.author | Younossi, Issah | |
dc.contributor.author | Nader, Fatema | |
dc.contributor.author | Racila, Andrei | |
dc.contributor.author | Stepanova, Maria | |
dc.contributor.author | Alqahtani, Saleh | |
dc.date.accessioned | 2023-09-07T08:02:55Z | |
dc.date.available | 2023-09-07T08:02:55Z | |
dc.date.issued | 2023 | en_US |
dc.identifier.citation | Younossi, Z. M., Yu, M. L., Yilmaz, Y., Alswat, K. A., Buti, M., Fernandez, M. I. C., Papatheodoridis, G., Hamid, S. S., El-Kassas, M., Chan, W. K., Duseja, A. K., Gordon, S. C., Eguchi, Y., Isakov, V. A., Roberts, S. K., Fan, J. G., Singal, A. K., Romero-Gómez, M., Ahmed, A., Ong, J., … Alqahtani, S. (2023). Clinical and patient-reported outcome profile of patients with hepatitis B viral infection from the Global Liver Registry™. Journal of viral hepatitis, 30(4), 335–344. https://doi.org/10.1111/jvh.13800 | en_US |
dc.identifier.issn | 1352-0504 | |
dc.identifier.issn | 1365-2893 | |
dc.identifier.uri | https://doi.org/10.1111/jvh.13800 | |
dc.identifier.uri | https://hdl.handle.net/11436/8279 | |
dc.description.abstract | Chronic hepatitis B (CHB) infection is one of the most common causes of cirrhosis and liver cancer worldwide. Our aim was to assess clinical and patient-reported outcome (PRO) profile of CHB patients from different regions of the world using the Global Liver Registry. The CHB patients seen in real-world practices are being enrolled in the Global Liver Registry. Clinical and PRO (FACIT-F, CLDQ, WPAI) data were collected and compared to baseline data from CHB controls from clinical trials. The study included 1818 HBV subjects (48 +/- 13 years, 58% male, 14% advanced fibrosis, 7% cirrhosis) from 15 countries in 6/7 Global Burden of Disease super-regions. The rates of advanced fibrosis varied (3-24%). The lowest PRO scores across multiple domains were in HBV subjects from the Middle East/North Africa (MENA), the highest - Southeast/East and South Asia. Subjects with advanced fibrosis had PRO impairment in 3 CLDQ domains, Activity of WPAI (p < 0.05). HBV subjects with superimposed fatty liver had more PRO impairments. In multivariate analysis adjusted for location, predictors of PRO impairment in CHB included female sex, advanced fibrosis, and non-hepatic comorbidities (p < 0.05). In comparison to Global Liver Registry patients, 242 controls from clinical trials had better PRO scores (Abdominal, Emotional, and Systemic scores of CLDQ, all domains of WPAI) (p < 0.05). In multivariate analysis with adjustment for location and clinicodemographic parameters, the associations of PROs with the enrollment setting (real-life Global Liver Registry vs. clinical trials) were no longer significant (all p > 0.10). The clinico-demographic portrait of CHB patients varies across regions of the world and enrollment settings. Advanced fibrosis and non-hepatic comorbidities are independently associated with PRO impairment in CHB patients. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Wiley | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Emotional well-being | en_US |
dc.subject | Fatigue | en_US |
dc.subject | Fatty liver | en_US |
dc.subject | Physical functioning | en_US |
dc.subject | Viral hepatitis | en_US |
dc.subject | Work productivity | en_US |
dc.title | Clinical and patient-reported outcome profile of patients with hepatitis B viral infection from the Global Liver Registry (TM) | en_US |
dc.type | article | en_US |
dc.contributor.department | RTEÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü | en_US |
dc.contributor.institutionauthor | Yılmaz, Yusuf | |
dc.identifier.doi | 10.1111/jvh.13800 | en_US |
dc.identifier.volume | 30 | en_US |
dc.identifier.issue | 4 | en_US |
dc.identifier.startpage | 335 | en_US |
dc.identifier.endpage | 344 | en_US |
dc.relation.journal | Journal of Viral Hepatitis | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |