Yazar "Kalkan, Yıldıray" için PubMed İndeksli Yayınlar Koleksiyonu listeleme
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High dose zoledronic acid increases ischemia-reperfusion damage of the liver
Aydın, İbrahim; Şehitoğlu, İbrahim; Özer, Emel; Kalkan, Yıldıray; Tümkaya, Levent; Cüre, Medine Cumhur; Cüre, Erkan (Verduci Publisher, 2021)OBJECTIVE: Zoledronic acid (ZA), a nitrogen-containing bisphosphonate, has been reported to exhibit a protective effect against cancers and prevent bone fractures. It also induces apoptosis by increasing proinflammatory ... -
Histopathological effects of intramuscular metamizole sodium on rat sciatic nerve
Emir, Abdurrahman; Kalkan, Yıldıray; Bostan, Habib (Mashhad Univ Med Sciences, 2016)Objective(s): We investigated the histopathological effects of metamizole sodium (MS) on the sciatic nerve. Materials and Methods: This study was performed using 48 adult male Wistar albino rats. Ten groups were constituted ... -
Immune modulatory and antioxidant effects of melatonin in experimental periodontitis in rats
Kara, Adem; Akman, Sümeyra; Özkanlar, Seçkin; Tozoğlu, Ümmühan; Kalkan, Yıldıray; Çanakcı, Cenk Fatih; Tozoğlu, Sinan (Elsevier, 2013)Melatonin is an important antioxidant, and through its anti-inflammatory effects it can control immune responses, oxidative stress, and defense cell infiltration. Periodontitis is a disease of the oral cavity and the ... -
Influence of infliximab pretreatment on ischemia/reperfusion injury in rat intestine
Akdoğan, Remzi Adnan; Kalkan, Yıldıray; Tümkaya, Levent; Alacam, Hasan; Erdivanlı, Başar; Aydın, İbrahim (Via Medica, 2014)The Pringle maneuver is used in hepatic surgery to prevent blood loss but is associated with ischemia-reperfusion injury. To investigate the effect of infliximab on inflammation and apoptosis in rat intestinal mucosa during ... -
Is adalimumab protective in ischemia‐reperfusion injury in lung?
Kurt, Aysel; Tümkaya, Levent; Kalkan, Yıldıray; Türüt, Hasan; Cüre, Medine Cumhur; Cüre, Erkan; Şehitoğlu, İbrahim; Bilgin, Hacer; Usta, Mustafa (Mashhad University of Medical Sciences, 2015)Objective(s): Increasing cytokines and reactive oxygen species (ROS) during ischemia reperfusion (I?R) leads to the lung damage. Adalimumab (Ada) is a potent tumor necrosis factor?alpha (TNF??) inhibitor agent. We aimed ... -
Is resveratrol a potential substitute for leuprolide acetate in experimental endometriosis?
Tekin, Yeşim Bayoğlu; Güven, Süleyman; Kırbaş, Aynur; Kalkan, Yıldıray; Tümkaya, Levent; Güven, Emine Seda Güvendağ (Elsevier Science Bv, 2015)Objective: Resveratrol, a phytoalexin polyphenol, has anti-angiogenic, antioxidant, anti-inflammatory properties. We aimed to compare the anti-inflammatory and anti-angiogenic effects of resveratrol and leuprolide acetate ... -
Lasting hepatotoxic effects of prenatal mobile phone exposure
Yılmaz, Adnan; Tümkaya, Levent; Akyıldız, Kerimali; Kalkan, Yıldıray; Bodur, Ali Fuat; Sargın, Fatma; Efe, Hasan; Uydu, Hüseyin Avni; Yazıcı, Zihni Açar (Taylor & Francis Ltd, 2017)Objective: in this study, the livers of rats born to mothers exposed to electromagnetic field (EMF) were examined 60 days postpartum for biochemical and histopathological changes.Methods: Pregnant rats were exposed to ... -
Mobile phone radiation during pubertal development has no effect on testicular histology in rats
Tümkaya, Levent; Kalkan, Yıldıray; Baş, Orhan; Yılmaz, Adnan (Sage Publications Inc, 2016)Mobile phones are extensively used throughout the world. There is a growing concern about the possible public health hazards posed by electromagnetic radiation emitted from mobile phones. Potential health risk applies ... -
The neuroprotective effect of glycyrrhizic acid on an experimental model of focal cerebral ischemia in rats
Akman, Tarık; Güven, Mustafa; Aras, Adem Bozkurt; Özkan, Adile; Sen, Halil Murat; Okuyucu, Ali; Kalkan, Yıldıray; Şehitoğlu, İbrahim; Şilan, Coşkun; Coşar, Murat (Springer/Plenum Publishers, 2015)Cerebral ischemia is still one of the most important topics in neurosciences. Our study aimed to investigate the neuroprotective and anti-oxidant effects of glycyrrhizic acid on focal cerebral ischemia in rats. Twenty-four ... -
Neuroprotective effect of p-coumaric acid in rat model of embolic cerebral ischemia
Güven, Mustafa; Aras, Adem Bozkurt; Akman, Tarık; Şen, Halil Murat; Özkan, Adile; Salis, Osman; Şehitoglu, İbrahim; Kalkan, Yıldıray; Şilan, Coşkun; Deniz, Mustafa; Coşar, Murat (Mashhad Univ Med Sciences, 2015)Objective(s): Stroke poses a crucial risk for mortality and morbidity. Our study aimed to investigate the effect of p-coumaric acid on focal cerebral ischemia in rats. Material and Methods: Rats were randomly divided into ... -
Neuroprotective effects of daidzein on focal cerebral ischemia injury in rats
Aras, Adem Bozkurt; Güven, Mustafa; Akman, Tarık; Özkan, Adile; Şen, Halil Murat; Düz, Uğur; Kalkan, Yıldıray; Coşkun, Şilan; Coşar, Murat (Shenyang Editorial Dept Neural Regeneration Res, 2015)Daidzein, a plant extract, has antioxidant activity. It is hypothesized, in this study, that daidzein exhibits neuroprotective effects on cerebral ischemia. Rat models of middle cerebral artery occlusion were intraperitoneally ... -
Neurotoxicity of various root canal sealers on rat sciatic nerve: an electrophysiologic and histopathologic study
Kılkış, Buket Tuğ; Er, Kürşat; Taşdemir, Tamer; Yıldırım, Mehmet; Taşkesen, Fatih; Tümkaya, Levent; Kalkan, Yıldıray; Serper, Ahmet (Springer Heidelberg, 2015)Objectives the aim of this study was to compare the neurotoxicity of various root canal sealers on rat sciatic nerve by electrophysiologic and histopathologic analyses. Materials and methods A total of 40 male rats were ... -
A novel model approach for esophageal burns in rats: a comparison of three methods
Kalkan, Yıldıray; Tümkaya, Levent; Akdoğan, Remzi Adnan; Yücel, Ahmet Fikret; Tomak, Yakup; Şehitoğlu, İbrahim; Pergel, Ahmet; Kurt, Aysel (Sage Publications Inc, 2015)Background: Corrosive esophageal injury causes serious clinical problems. We aimed to create a new experimental esophageal burn model using a single catheter without a surgical procedure. Materials and methods: We conducted ... -
The protective effect of adalimumab on renal injury in a model of abdominal aorta cross-clamping
Cüre, Medine Cumhur; Cüre, Erkan; Kalkan, Yıldıray; Tümkaya, Levent; Aydın, İbrahim; Kırbaş, Aynur; Efe, Hasan; Kurt, Aysel; Yüce, Süleyman (Wroclaw Medical Univ, 2016)Background. Adalimumab (ADA) is a potent inhibitor of tumor necrosis factor (TNF-alpha). ADA treatment suppresses proinflammatory cytokines, leading to a decrease or inhibition of the inflammatory process. Objectives. the ... -
The protective effect of infliximab against carbon tetrachloride-induced acute lung injury
Kurt, Aysel; Tümkaya, Levent; Yüce, Süleyman; Türüt, Hasan; Cüre, Medine Cumhur; Şehitoğlu, İbrahim; Kalkan, Yıldıray; Pusuroğlu, Gökhan; Cüre, Erkan (Mashhad Univ Med Sciences, 2016)Objective(s): Carbon tetrachloride (CCl4) causes pulmonary toxicity. Infliximab (Ib) is a potent inhibitor of tumor necrosis factor-alpha (TNF-alpha). We aimed to investigate whether Ib has a protective effect on CCl4 ... -
Protective effect of infliximab against carbon tetrachloride-induced hepatotoxicity
Şehitoğlu, İbrahim; Tümkaya, Levent; Bedir, Recep; Özer, Ender; Cüre, Medine Cumhur; Yüce, Süleyman; Kalkan, Yıldıray; Cüre, Erkan (Begell House Inc, 2015)Carbon tetrachloride (CCl4), a solvent frequently used in industry, can cause acute liver failure and liver fibrosis. Infliximab (Ib), a potent tumor necrosis factor alpha blocker, has a protective effect on the liver. ... -
The protective effect of infliximab on cisplatin-induced intestinal tissue toxicity
Aydın, İbrahim; Kalkan, Yıldıray; Özer, Ezgi Demir; Yücel, Ahmet Fikret; Pergel, Ahmet; Cüre, Erkan; Cüre, Medine Cumhur; Şahin, Dursun Ali (Verduci Publisher, 2014)OBJECTIVE: Cisplatin (CP) is a popular chemotherapeutic agent. However, high doses of CP may lead to severe side effects to the gastrointestinal system. the aim of this study was to investigate the protective effects of ... -
Protective effect of infliximab on methotrexate-induced liver injury in rats: Unexpected drug interaction
Cüre, Erkan; Kırbaş, Aynur; Tümkaya, Levent; Cüre, Medine Cumhur; Kalkan, Yıldıray; Yılmaz, Arif; Yüce, Süleyman (Wolters Kluwer Medknow Publications, 2015)Aims: Although methotrexate (mtx) is a widely used agent to treat cancer and inflammatory diseases, its hepatotoxic effect limits for clinical utility. We aimed to investigate whether infliximab (inf), an inhibitor of tumor ... -
Protective effect of Panax ginseng against serum biochemical changes and apoptosis in kidney of rats treated with gentamicin sulphate
Kalkan, Yıldıray; Kapakin, Kübra Asena Terim; Kara, Adem; Atabay, Tennur; Karadeniz, Ali; Şimşek, Nejdet; Karakuş, Emre; Can, İsmail; Yıldırım, Serap; Özkanlar, Seçkin; Şengül, Emin (Springer Link, 2012)The protective effects of Panax ginseng (PG) on gentamicin sulphate (GS) induced acute nephrotoxicity were investigated in rats. A total of 32 adult Sprague- Dawley rats were randomly divided into 4 equal groups and treated ... -
Protective effect of Panax ginseng against serum biochemical changes and apoptosis in liver of rats treated with carbon tetrachloride (CCl 4)
Karakuş, Emre; Karadeniz, Ali; Şimşek, Nejdet; Can, İsmail; Kara, Adem; Yıldırım, Serap; Kalkan, Yıldıray; Kısa, Fikrullah (Elsevier, 2011)The purpose of this study was to investigate possible beneficial effects of Panax ginseng (PG) on carbon tetrachloride (CCl 4)-induced acute hepatotoxicity in rats. CCl 4 challenge elevated serum enzyme activities of liver ...