Yazar "Tümkaya, Levent" için PubMed İndeksli Yayınlar Koleksiyonu listeleme
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Inhibition of methotrexate induced toxicity in the adult rat spleen by adalimumab
Bahçeci, İlkay; Tümkaya, Levent; Mercantepe, Tolga; Aslan, Nuray; Duran, Ömer Faruk; Söztanacı, Umut Serkan; Yazıcı, Zihni Açar (Taylor & Francis Ltd., 2022)Methotrexate (MTX) has been in use for the treatment of rheumatoid arthritis (RA), psoriasis, and cancer since 1948. Its toxic side effects on tissues and organs have been well documented but splenotoxicity has not been ... -
An investigation of the effects of metformin on ovarian ischemia-reperfusion injury in rats
Topçu, Atilla; Balık, Gülşah; Atak, Mehtap; Mercantepe, Tolga; Uydu, Hüseyin Avni; Tümkaya, Levent (Elsevier, 2019)Damage to the ovaries or tissue torsion can significantly reduce the ovarian reserve and thus cause severe gynecological and hormonal deficiencies. the discovery of new agents is always needed in the treatment of this ... -
An investigation of the effects of N-acetylcysteine on radiotherapy-induced testicular injury in rats
Topçu, Atilla; Mercantepe, Filiz; Rakıcı, Sema; Tümkaya, Levent; Uydu, Hüseyin Avni; Mercantepe, Tolga (Springer, 2019)According to data issued by the International Agency for Research on Cancer in 2012, the estimated number of new cases of all types of cancer worldwide was estimated to exceed 10 million, and 6 million of whom receive ... -
Investigation of the effects of white tea on liver fibrosis: An experimental animal model
Yılmaz, Hülya Kılıç; Türker, Merve; Kutlu, Eda Yılmaz; Mercantepe, Tolga; Pınarbaş, Esra; Tümkaya, Levent; Atak, Mehtap (Wiley, 2024)Liver fibrosis is a common, progressive disease that affects millions of patients worldwide. In this study, it was aimed at investigating the effect of white tea on liver fibrosis in an in-vivo environment by creating an ... -
Is adalimumab protective in ischemia‐reperfusion injury in lung?
Kurt, Aysel; Tümkaya, Levent; Kalkan, Yıldıray; Türüt, Hasan; Cüre, Medine Cumhur; Cüre, Erkan; Şehitoğlu, İbrahim; Bilgin, Hacer; Usta, Mustafa (Mashhad University of Medical Sciences, 2015)Objective(s): Increasing cytokines and reactive oxygen species (ROS) during ischemia reperfusion (I?R) leads to the lung damage. Adalimumab (Ada) is a potent tumor necrosis factor?alpha (TNF??) inhibitor agent. We aimed ... -
Is resveratrol a potential substitute for leuprolide acetate in experimental endometriosis?
Tekin, Yeşim Bayoğlu; Güven, Süleyman; Kırbaş, Aynur; Kalkan, Yıldıray; Tümkaya, Levent; Güven, Emine Seda Güvendağ (Elsevier Science Bv, 2015)Objective: Resveratrol, a phytoalexin polyphenol, has anti-angiogenic, antioxidant, anti-inflammatory properties. We aimed to compare the anti-inflammatory and anti-angiogenic effects of resveratrol and leuprolide acetate ... -
Lasting hepatotoxic effects of prenatal mobile phone exposure
Yılmaz, Adnan; Tümkaya, Levent; Akyıldız, Kerimali; Kalkan, Yıldıray; Bodur, Ali Fuat; Sargın, Fatma; Efe, Hasan; Uydu, Hüseyin Avni; Yazıcı, Zihni Açar (Taylor & Francis Ltd, 2017)Objective: in this study, the livers of rats born to mothers exposed to electromagnetic field (EMF) were examined 60 days postpartum for biochemical and histopathological changes.Methods: Pregnant rats were exposed to ... -
Long-term protective effects of lamotrigine in a rat ovarian ischemia-reperfusion model
Aktepe, Rıza; Üçüncü, Yılmaz; Tümkaya, Levent; Mercantepe, Tolga; Topçu, Atilla; Uydu, Hüseyin Avni; Atak, Mehtap (Elsevier, 2024)Ovarium torsion is a gynecological emergency that is common in women of reproductive age and requires early diagnosis and intervention. In this study, we aimed to investigate the long-term anatomical, histological and ... -
Melatonin ameliorates periodontitis related inflammatory stress at cardiac left ventricular tissues in rats
Köse, Oğuz; Bayraktar, Sevda Kurt; Akyıldız, Kerimali; Altın, Ahmet; Arabacı, Taner; Yemenoğlu, Hatice; Korkmaz, Mehmet Zihni; Köse, Taha Emre; Şener, Leyla Türker; Mercantepe, Tolga; Tümkaya, Levent; Yılmaz, Adnan (Wiley, 2020)BackgroundThe aim of this experimental rat study was to investigate the potential inflammatory effects of periodontitis on cardiac left ventricular tissue and the therapeutic activity of melatonin on these effects. ... -
Melatonin improves periodontitis-induced kidney damages by decreasing inflammatory stress and apoptosis in rats
Köse, Oğuz; Bayrakdar, Sevda Kurt; Ünver, Büşra; Altın, Ahmet; Akyıldız, Kerimali; Mercantepe, Tolga; Bostan, Semih Alperen; Arabacı, Taner; Türker Şener, Leyla; Köse, Taha Emre; Tümkaya, Levent; Yılmaz, Adnan; Kuluşlu, Göker (Wiley-Blackwell, 2020)Background: Two main aims of this animal study were to inspect the possible effects of periodontitis on the structure and functions of the kidneys and the therapeutic effectiveness of melatonin. Methods: Twenty-four male ... -
Mobile phone radiation during pubertal development has no effect on testicular histology in rats
Tümkaya, Levent; Kalkan, Yıldıray; Baş, Orhan; Yılmaz, Adnan (Sage Publications Inc, 2016)Mobile phones are extensively used throughout the world. There is a growing concern about the possible public health hazards posed by electromagnetic radiation emitted from mobile phones. Potential health risk applies ... -
The nephroprotective effect of amifostine in a cecal ligation-induced sepsis model in terms of oxidative stress and inflammation
Batçık, Şule; Tümkaya, Levent; Mercantepe, Tolga; Atak, Mehtap; Topçu, Atilla; Uydu, Hüseyin Avni; Mercantepe, F. (Verduci Editore, 2022)OBJECTIVE: Sepsis is responsible for more than 5 million deaths worldwide every year. The purpose of this study was to use amifostine to reduce acute kidney injury developing as a result of sepsis. MATERIALS AND METHODS: ... -
Neuroprotective effects of Vaccinium myrtillus on damage-related brain injury
Özdemir, Abdullah; Mercantepe, Tolga; Erdivanlı, Başar; Şen, Ahmet; Mercantepe, Filiz; Tümkaya, Levent; Uydu, Hüseyin Avni (2023)Traumatic brain injury may trigger the secondary brain injury, which has the potential to be reversible and thus preventable. Anthocyanins are phylotherapeutic plants, which are reported to exhibit anti-inflammatory ... -
Neurotoxicity of various root canal sealers on rat sciatic nerve: an electrophysiologic and histopathologic study
Kılkış, Buket Tuğ; Er, Kürşat; Taşdemir, Tamer; Yıldırım, Mehmet; Taşkesen, Fatih; Tümkaya, Levent; Kalkan, Yıldıray; Serper, Ahmet (Springer Heidelberg, 2015)Objectives the aim of this study was to compare the neurotoxicity of various root canal sealers on rat sciatic nerve by electrophysiologic and histopathologic analyses. Materials and methods A total of 40 male rats were ... -
A novel model approach for esophageal burns in rats: a comparison of three methods
Kalkan, Yıldıray; Tümkaya, Levent; Akdoğan, Remzi Adnan; Yücel, Ahmet Fikret; Tomak, Yakup; Şehitoğlu, İbrahim; Pergel, Ahmet; Kurt, Aysel (Sage Publications Inc, 2015)Background: Corrosive esophageal injury causes serious clinical problems. We aimed to create a new experimental esophageal burn model using a single catheter without a surgical procedure. Materials and methods: We conducted ... -
Pathological findings observed in the kidneys of postnatal male rats exposed to the 2100 MHz electromagnetic field
Bedir, Recep; Tümkaya, Levent; Mercantepe, Tolga; Yılmaz, Adnan (Elsevier Science Inc, 2018)Background. the widespread use by young people of modern communication devices such as mobile phones means that they are particularly exposed to electromagnetic fields (EMF) and other problems. However, few studies have ... -
Pelvic radiation-induced testicular damage: an experimental study at 1 gray
Rakıcı, Sema Yılmaz; Güzel, Ali İrfan; Tümkaya, Levent; Nalkıran, Hatice Sevim; Mercantepe, Tolga (Taylor & Francis Inc, 2020)Therapeutic radiation of the pelvic region has been shown to cause damage to testicular germ cells. in this study we aimed to evaluate the effects of a low therapeutic dose of 1 Gy on the induction of cellular and histological ... -
Periodontitis exacerbates the renal degenerative effects of obesity in rats
Kurt-Bayrakdar, Sevda; Köse, Oğuz; Altın, Ahmet; Akyıldız, Kerimali; Mercantepe, Tolga; Bostan, Semih Alperen; Köse, Taha Emre; Tümkaya, Levent; Yılmaz, Adnan (Wiley, 2021)Background/objectives Obesity and periodontitis are systemic subclinical inflammatory diseases with established negative renal effects. The aim of this animal study was to thoroughly investigate the possible effects of ... -
The potential antioxidant effect of N-acetylcysteine on X-ray ionizing radiation-induced pancreas islet cell toxicity
Yılmaz, Hamit; Mercantepe, Tolga; Tümkaya, Levent; Merca; Yılmaz, Adnan; Rakıcı, Sema Yılmaz (Elsevier, 2023)Purpose Previous research has highlighted the impact of X-ray irradiation-induced organ damage, on cancer patients after radiation therapy. The ionizing radiation-induced oxidative stress causes injury to the pancreatic ... -
Prenatal effects of a 1,800-MHz electromagnetic field on rat livers
Tümkaya, Levent; Yılmaz, Adnan; Akyıldız, Kerimali; Mercantepe, Tolga; Yazıcı, Zihni Acar; Yılmaz, Hamit (Karger, 2019)The use of devices, including mobile phones, generating electromagnetic fields (EMF) is widespread and is progressively increasing. It has also been shown that EMF may have detrimental effects. This is the first study to ...