dc.contributor.author | Zuhur, Sayid Shafi | |
dc.contributor.author | Öztürk, Beyza Olcay | |
dc.contributor.author | Keskin, Ümran | |
dc.contributor.author | Uysal, Serhat | |
dc.contributor.author | Hacıoğlu, Aysa | |
dc.contributor.author | Avcı, Uğur | |
dc.contributor.author | Karslı, Seda | |
dc.contributor.author | Andaç, Burak | |
dc.contributor.author | Özbay, Ümit Nur | |
dc.contributor.author | Kılınç, Faruk | |
dc.contributor.author | Erol, Selvinaz | |
dc.contributor.author | Çatak, Merve | |
dc.contributor.author | Sodan, Hülyanur | |
dc.contributor.author | Pekkolay, Zafer | |
dc.contributor.author | Burhan, Şebnem | |
dc.contributor.author | Akbaba, Gülhan | |
dc.contributor.author | Ateş, Coşkun | |
dc.contributor.author | Yorulmaz, Göknur | |
dc.contributor.author | Tekin, Sakin | |
dc.contributor.author | Topçu, Birol | |
dc.contributor.author | Tuna, Mazhar Müslüm | |
dc.contributor.author | Kadıoğlu, Pınar | |
dc.contributor.author | Gönen, Mustafa Sait | |
dc.contributor.author | Karaca, Züleyha | |
dc.contributor.author | Çiftçi, Sema | |
dc.contributor.author | Çelik, Mehmet | |
dc.contributor.author | Güldiken, Sibel | |
dc.contributor.author | Tüzün, Dilek | |
dc.contributor.author | Altuntaş, Yüksel | |
dc.contributor.author | Aktürk, Müjde | |
dc.contributor.author | Niyazioğlu, Mutlu | |
dc.contributor.author | Çınar, Neşe | |
dc.contributor.author | Gül, Özen Öz | |
dc.contributor.author | Kebapçı, Medine Nur | |
dc.contributor.author | Akalın, Ayşen | |
dc.contributor.author | Bayraktaroğlu, Taner | |
dc.contributor.author | Elbüken, Gülşah | |
dc.date.accessioned | 2024-04-30T07:47:21Z | |
dc.date.available | 2024-04-30T07:47:21Z | |
dc.date.issued | 2024 | en_US |
dc.identifier.citation | Zuhur, S. S., Ozturk, B. O., Keskin, U., Uysal, S., Hacioglu, A., Avci, U., Karsli, S., Andac, B., Ozbay, U. N., Kilinc, F., Erol, S., Catak, M., Sodan, H., Pekkolay, Z., Burhan, S., Akbaba, G., Ates, C., Yorulmaz, G., Tekin, S., Topcu, B., … Elbuken, G. (2024). Disease-free survival and the prognostic factors affecting disease-free survival in patients with medullary thyroid carcinoma: a multicenter cohort study. Endocrine, 10.1007/s12020-024-03809-0. Advance online publication. https://doi.org/10.1007/s12020-024-03809-0 | en_US |
dc.identifier.issn | 1355-008X | |
dc.identifier.issn | 1559-0100 | |
dc.identifier.uri | https://doi.org/10.1007/s12020-024-03809-0 | |
dc.identifier.uri | https://hdl.handle.net/11436/8939 | |
dc.description.abstract | Purpose Despite several factors that may have been associated with poor disease-free survival (DFS) in patients with medullary thyroid carcinoma (MTC), only a few studies have evaluated the prognostic factors affecting DFS in MTC patients. Therefore, this study evaluated the prognostic factors affecting DFS, in a large number of patients with MTC. Methods Patients treated for MTC were retrospectively analyzed. Patients were stratified as having persistent/recurrent disease and no evidence of disease (NOD) at the last follow-up. The factors affecting DFS after the initial therapy and during the follow-up period were investigated. Results This study comprised 257 patients [females 160 (62.3%), hereditary disease 48 (18.7%), with a mean follow-up time of 66.8 +/- 48.5 months]. Persistent/recurrent disease and NOD were observed in 131 (51%) and 126 (49%) patients, respectively. In multivariate analysis, age > 55 (HR: 1.65, p = 0.033), distant metastasis (HR: 2.41, p = 0.035), CTN doubling time (HR: 2.7, p = 0.031), and stage III vs. stage II disease (HR 3.02, p = 0.048) were independent predictors of persistent/recurrent disease. Although 9 (8%) patients with an excellent response after the initial therapy experienced a structural recurrence, the absence of an excellent response was the strongest predictor of persistent/recurrent disease (HR: 5.74, p < 0.001). Conclusions The absence of an excellent response after initial therapy is the strongest predictor of a worse DFS. However, a significant proportion of patients who achieve an excellent response could experience a structural recurrence. Therefore, careful follow-up of patients, including those achieving an excellent response is essential. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Springer | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Medullary thyroid carcinoma | en_US |
dc.subject | Disease-free survival | en_US |
dc.subject | Excellent response | en_US |
dc.subject | Prognosis | en_US |
dc.title | Disease-free survival and the prognostic factors affecting disease-free survival in patients with medullary thyroid carcinoma: a multicenter cohort study | en_US |
dc.type | article | en_US |
dc.contributor.department | RTEÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü | en_US |
dc.contributor.institutionauthor | Avcı, Uğur | |
dc.identifier.doi | 10.1007/s12020-024-03809-0 | en_US |
dc.relation.journal | Endocrine | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |