Kurum Yazarı "Sandallı, Cemal" FEF, Biyoloji Bölümü Koleksiyonu İçin Listeleme
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Effect of mazEF, higBA and relBE toxin-antitoxin systems on antibiotic resistance in Pseudomonas aeruginosa and Staphylococcus isolates
Coşkun, Umut Safiye Say; Çiçek, Ayşegül Çopur; Kılınç, Çetin; Güçkan, Rıdvan; Dağcıoğlu, Yelda; Demir, Osman; Sandallı, Cemal (Med Coll Malawi, 2018)Background A toxin-antitoxin (TA) system is a set of two or more closely linked genes that are encoded as a poison and a corresponding antidote on a protein. in typical bacterial physiology, an antitoxin binds to a toxin ... -
Elucidation of Bioactive compounds in flower extracts of Camellia sinensis by HPLC-DAD-MS/MS and their inhibitory effects on replicative bacterial DNA polymerases
Turumtay, Halbay; Tombuloğlu, Hüseyin; Er, Havva; Sandallı, Cemal; Turumtay, Emine Akyüz (Elsevier, 2022)Camellia sinensis L. (C. sinensis) is an economically valuable crop whose leaves are used to produce tea. Tea flowers extracts (TFE) have been tested for their DNA polymerase inhibitory effect experimentally and in silico. ... -
Evaluation of genetic diversity of cultivated tea clones (Camellia sinensis (L.) Kuntze) in the eastern black sea coast by inter-simple sequence repeats (ISSRS)
Beriş, Fatih Şaban; Pehlivan, Necla; Kaç, Melike; Haznedar, Ayhan; Coşkun, Fatih; Sandallı, Cemal (Serbian Genetics Soc, 2016)Tea is the most globally consumed drink after spring water and an important breeding plant with high economical value in Turkey. in half a century, various kinds of tea cultivars have been bred in Turkey to improve the ... -
Evaluation of the carbapenem inactivation method for detection of carbapenemase-producing gram-negative bacteria in comparison with the RAPIDEC CARBA NP
Aktaş, Elif; Malkoçoğlu, Gülşah; Otlu, Barış; Çiçek, Ayşegül Çopur; Kulah, Canan; Cömert, Füsun; Sandallı, Cemal; Gürsoy, Nafia Canan; Erdemir, Duygu; Bulut, Mehmet Emin (Mary Ann Liebert, Inc, 2017)Timely detection of carbapenemases by both phenotypic and genotypic methods is essential for developing strategies to control the spread of infections by carbapenem-resistant isolates and related morbidity and mortality. ... -
High prevalence of NDM metallo-β-lactamase among ESBL-producing Escherichia coli İsolates
Çetinkol, Yeliz; Sandallı, Cemal; Çalgın, Mustafa Kerem; Yıldırım, Arzu Altunçekiç; Akyıldız, Esma; Karaman, Esin; Çiçek, Ayşegül Çopur (Akademiai Kiado Zrt, 2017)Resistance to beta-lactams in Enterobacteriaceae has been increasing worldwide. This study aimed to determine the frequency of beta-lactamase genes and antibiotic resistance rates of 140 extended-spectrum beta-lactamase ... -
High-throughput screening of inhibitory effect of medicinal plants on bacterial DNA polymerases
Sandallı, Cemal; Turumtay, Emine Akyüz; Turumtay, Halbay (Elsevier Science Bv, 2016)Antibiotic resistance is a serious and increasing problem in medicine. Particularly, pathogens are one of the most important public health issues at the 21st Century. -
The internal bacterial diversity of stored product pests
Sevim, Ali; Sevim, Elif; Demirci, Meryem; Sandallı, Cemal (Bmc, 2016)Symbiotic bacteria associated with insects play important roles in different physiological processes such as digestion, insect behavior, defense and providing essential nutrition in insect gut. in addition, these bacteria ... -
Kinetic characterization of GES-22 beta-lactamase harboring the M169L clinical mutation
Saral, Ayşegül; Leonard, David A.; Düzgün, Azer Özad; Çiçek, Ayşegül Çopur; June, Cynthia M.; Sandallı, Cemal (Japan Antibiotics Research Assoc, 2016)The class A p-lactamase GES-22 has been identified in Acinetobacter baumannii isolates in Turkey, and subsequently shown to differ from GES-11 by a single substitution (M169L). Because M169 is part of the omega loop, a ... -
Klinik örneklerden izole edilen trimetoprim-sülfametoksazole dirençli stenotrophomonas maltophilia suşlarında integron, sul1-2 ve dfr genlerinin araştırılması
Özkaya, Esra; Aydın, Faruk; Bayramoğlu, Gülçin; Buruk, Celal Kurtuluş; Sandallı, Cemal (Ankara Microbiology Soc, 2014)Stenotrophomonas maltophilia, which is a non-fermentative gram-negative bacillus, has an increasing importance in nosocomial and opportunistic infections. Since it exhibits resistance to numerous broad-spectrum antibiotics ... -
Molecular characterization of antibiotic resistant Escherichia coli strains isolated from tap and spring waters in a coastal region in Turkey
A hundred and seventeen antibiotic-resistant Escherichia coli strains were isolated from public tap and spring waters which were polluted by fecal coliforms. There were no significant differences between two water sources ... -
Molecular epidemiology of clinical Pseudomonas aeruginosa isolates carrying IMP-1 metallo-β-lactamase gene in a university hospital in Turkey
Özgümüş, Osman Birol; Caylan, Rahmet; Tosun, İlknur; Sandallı, Cemal; Aydın, Kemalettin; Köksal, İftihar (2007)Pseudomonas aeruginosa isolates carrying IMP- or VIM-type metallo-?-lactamase (MBL) have been increasingly reported in hospitals worldwide. One hundred P. aeruginosa clinical isolates from unrelated inpatients hospitalized ... -
Nationwide study of Escherichia coli producing extended-spectrum beta-lactamases TEM, SHV and CTX-M in Turkey
Çiçek, Ayşegül Çopur; Saral, Ayşegül; Düzgün, Azer Özad; Yaşar, Ekrem; Çizmeci, Zeynep; Balcı, Pervin Özlem; Sarı, Fatma; Fırat, Mehmet; Altıntop, Yasemin Ay; Ak, Sibel; Çalışkan, Ahmet; Yıldız, Nazan; Sancaktar, Metin; Budak, Emine Esra; Ertürk, Ayşe; Özgüm, Osman Birol; Sandallı, Cemal (Nature Publishing Group, 2013)Four hundred and forty extended-spectrum beta-lactamase (ESBL)-producing Escherichia coli isolates were collected from 10 different hospitals in Turkey between 2011 and 2012. Clinical specimens consisted of urine (80.45%), ... -
A new DNA polymerase i from Geobacillus caldoxylosilyticus TK4: Cloning, characterization, and mutational analysis of two aromatic residues
Sandallı, Cemal; Singh, Kamalendra; Modak, Mukund J.; Ketkar, Amit; Çanakçı, Sabriye; Demir, İsmail; Belduz, Ali Osman (Springer, 2009)DNA polymerase I gene was cloned and sequenced from the thermophilic bacterium Geobacillus caldoxylosilyticus TK4. The gene is 2,634 bp long and encodes a protein of 878 amino acids in length. The enzyme has a molecular ... -
A Novel integron gene cassette harboring VIM-38 Metallo-beta-lactamase in a clinical pseudomonas aeruginosa isolate
Beriş, Fatih Şaban; Akyıldız, Esma; Düzgün, Azer Özad; Coşkun, Umut Safiye Say; Sandallı, Cemal; Çiçek, Ayşegül Çopur (Korean Soc Laboratory Medicine, 2016)Dear Editor, Multidrug resistance of Pseudomonas aeruginosa has been attributed to both intrinsic and acquired antibiotic-resistance mechanisms. Multidrug-resistant (MDR) P. aeruginosa isolates have become a serious ... -
OXA- and GES-type beta-lactamases predominate in extensively drug-resistant Acinetobacter baumannii isolates from a Turkish University Hospital
Çiçek, Ayşegül Çopur; Saral, Ayşegül; Iraz, Meryem; Ceylan, Ayşenur; Düzgün, Azer Özad; Peleg, Anton Y.; Sandallı, Cemal (Elsevier Sci Ltd, 2014)We determined the antibiotic susceptibility and genetic mechanisms of resistance in clinical strains of Acinetobacter baumannii from Istanbul, Turkey. A total of 101 clinical strains were collected between November 2011 ... -
PaCaHa inhibits proliferation of human cancer cells in vitro
Background/aim: The aim of this study was to investigate the antiproliferative and cytotoxic effects of a newly synthesized molecule named paracetamol acetohydroxamic acid (PaCaHa) on human neoplastic cell lines. Materials ... -
Plant metabolomics and strategies
Turumtay, Halbay; Sandallı, Cemal; Turumtay, Emine Akyüz (Springer International Publishing, 2016)Plant metabolomics is the study of metabolic pathways and processes to understand how plants grow and carry out functions. Over the past years, there has been a switch to a more holistic view of metabolomes. Instead of ... -
Prevalence of integrons and a new dfrA17 variant in Gram-negative bacilli which cause community-acquired infections
Sandallı, Cemal; Buruk, Celal Kurtuluş; Sancaktar, Metin; Özgümüş, Osman Birol (Wiley, 2010)A hundred and eleven Gram-negative bacilli from community-acquired infections were characterized by antimicrobial susceptibility testing, screened for class 1 and 2 integrons, and statistically evaluated for the association ... -
Three seasonal comprehensive evaluation process of Digitalis trojana Ivan's phenolics
Turumtay, Halbay; Turumtay, Emine Akyüz; Selvi, Emine Kılıçkaya; Şahin, Hüseyin; Sandallı, Cemal; Yazıcı, Zihni Açar (Elsevier Science Bv, 2016)Digitalis trojana Ivan, a member of Digitalis genus, has highly bioactive properties due to, efficient phenolics. These compounds have shown to convert into each other in a limited time. Seasonal fluctuations of this plant ...