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Synthesis and anticancer activities of amide-bridged coumarin–quinazolinone hybrid compounds

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info:eu-repo/semantics/closedAccess

Date

2024

Author

Çalışkan, Nedime
Menteşe, Emre
Yılmaz, Fatih
İlhan, Muhammed Süleyman

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Citation

Çalişkan, N., Menteşe, E., Yilmaz, F., & Ilhan, M. S. (2024). Synthesis and Anticancer Activities of Amide-Bridged Coumarin–Quinazolinone Hybrid Compounds. Russian Journal of Organic Chemistry, 60(5), 918–926. https://doi.org/10.1134/s1070428024050142

Abstract

Abstract: Some novel 3-aminoquinazolin-4(3H)-one derivatives were synthesized by the reaction of 2-aminobenzhydrazide and corresponding iminoester hydrochlorides and then reacted with coumarin-3-carbonyl chloride to obtain novel coumarin–quinazolinone hybrids. The synthesized hybrid compounds were screened for their anticancer activity against various human cancer and normal cell lines. N-{2-[(4-Bromo- and N-{2-[(3-bromo-phenyl)methyl]-4-oxoquinazolin-3(4H)-yl}-2-oxo-2H-1-benzopyran-3-carboxamides exhibited the highest cytotoxic effect on the PC-3 prostate cancer cell line: IC50 35.3 ± 0.6 and 36.8 ± 0.8 µg/L, respectively. N-{2-[(4-Fluoro-, N-{2-[(4-bromo-, and N-{2-[(3,4-dichloro-phenyl)methyl]-4-oxoquinazolin-3(4H)-yl}-2-oxo-2H-1-benzopyran-3-carboxamides showed the highest activity against the MCF-7 breast cancer cell line: IC50 48.5 ± 0.4, 44.8 ± 0.4 and 46.1 ± 0.5 µg/L, respectively.

Source

Russian Journal of Organic Chemistry

Volume

60

Issue

5

URI

https://doi.org/10.1134/s1070428024050142
https://hdl.handle.net/11436/9256

Collections

  • FEF, Kimya Bölümü Koleksiyonu [478]
  • Scopus İndeksli Yayınlar Koleksiyonu [6032]
  • Teknik Bilimler Meslek Yüksekokulu Koleksiyonu [202]



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