Kurum Yazarı "Tümkaya, Levent" TF, Dahili Tıp Bilimleri Bölümü Koleksiyonu İçin Listeleme
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Effects of gadodiamide and gadoteric acid on rat kidneys: A comparative study
Çeliker, Fatma Beyazal; Tümkaya, Levent; Mercantepe, Tolga; Beyazal, Mehmet; Turan, Arzu; Beyazal Polat, Hatice; Suzan, Zehra Topal; İnecikli, Mehmet Fatih; Akyıldız, Kerimali; Yılmaz, Adnan (Wiley, 2019)Background Gadolinium-based contrast agents are complex chelates to provide contrast in NRI. However, recent studies have highlighted the deposition of free Gd+3 ion in various tissues. Purpose To evaluate the histopathological ... -
Effects of gadolinium-based contrast agents on submandibular gland tissue in rats
Çeliker, Fatma Beyazal; Tümkaya, Levent; Yılmaz, Adnan; Coşkun, Zerrin Özergin; Çeliker, Metin; Oğhan, Fatih; Mercantepe, Tolga; Terzi, Suat; Dursun, Engin (Springer, 2018)The aim of this prospective animal study is to investigate the influence of multiple administrations of macrocyclic ionic (gadoteric acid) and linear nonionic (gadodiamide) gadolinium-based contrast agents (GBCA) on ... -
Effects of gadolinium-based MRI contrast agents on liver tissue
Mercantepe, Tolga; Tümkaya, Levent; Çeliker, Fatma Beyazal; Suzan, Zehra Topal; Çınar, Seda; Akyıldız, Kerimali; Mercantepe, Filiz; Yılmaz, Adnan (Wiley, 2018)BackgroundPurposeMRI with contrast is often used clinically. However, recent studies have reported a high accumulation of gadolinium-based contrast agents (GBCAs) in kidney, liver, and spleen tissues in several mouse models. ... -
Effects of infliximab against methotrexate toxicity in splenic tissue via the regulation of CD3, CD68, and C200R in rats
Mercantepe, Tolga; Tümkaya, Levent; Mercantepe, Filiz (Karger, 2018)Methotrexate (MTX), which has been used in clinical practice for approximately 70 years, is still widely employed in the treatment of rheumatoid arthritis (RA), psoriasis, and cancer. Although MTX toxicity causes nephrotoxicity, ... -
The effects of infliximab on laminin, NF kappa B, and Anti-TNF expression through Its effect on ischemic liver tissue
Akdoğan, Remzi Adnan; Kalkan, Yıldıray; Tümkaya, Levent; Rakıcı, Halil; Akdoğan, Elif (Hindawi Ltd, 2016)The aim of this study was to investigate the possible protective effects of infliximab on expression of laminin, anti-TNF, and NF kappa B in the rat hepatic cells after ischemia/reperfusion (I/R). A total of 30 male Wistar ... -
The effects of long-term doppler ultrasound exposure in the prenatal period on renal tissue physiology in rats
Çeliker, Fatma Beyazal; Tümkaya, Levent; Mercantepe, Tolga; Zengin, Ertan; Beyazal, Mehmet; Turan, Arzu; Polat, Hatice Beyazal; Suzan, Zehra Topal; Yılmaz, Adnan (Taylor & Francis Inc., 2022)Doppler ultrasonography (DUSG) is widely used for fetal evaluations. This study investigated the effects of new generation Doppler ultrasound application at different frequencies during pregnancy on postnatal renal ... -
The effects of N-acetylcysteine on radiotherapy-induced small intestinal damage in rats
Mercantepe, Filiz; Topçu, Atilla; Rakıcı, Sema; Tümkaya, Levent; Yılmaz, Adnan (Sage Publications Ltd, 2019)Six million cancer patients worldwide receive radiotherapy, either alone or in combination with other cancer treatments annually. the purpose of this study was to investigate, at the structural and molecular levels, the ... -
Effects of sugammadex and rocuronium mast cell number and degranulation in rat liver
Tomak, Yakup; Yılmaz, Adnan; Bostan, Habib; Tümkaya, Levent; Altuner, Durdu; Kalkan, Yıldıray; Erdivablı, Başar (Wiley, 2012)We investigated the effect of rocuronium- and sugammadex-induced mast cell increase and degranulation in rat portal triads. Forty-two rats, in six groups, received either rocuronium 1 mg.kg -1; sugammadex 15 mg.kg -1; ... -
The effects of topiramate on methotrexate- induced pancreatic injury
Mercantepe, Filiz; Tümkaya, Levent (Necmettin Erbakan Üniversitesi, Meram Tıp Fakültes, 2023)Amaç: Bu çalışmada metotreksat ilişkili pankreas hasarında topiramatın pankreasın Langerhans adacık hücreleri üzerine olan etkisinin araştırılması amaçlandı. Gereçler ve Yöntem: Çalışma 04 Temmuz- 24 Temmuz 2022 tarihinde ... -
The effects of white tea (Camellia Sinensis) and infliximab against cisplatin-induced testicular damage via oxidative stress and apoptosis
Çakıroğlu, Şenay; Mercantepe, Tolga; Tümkaya, Levent; Uydu, Hüseyin Avni; Topçu, Atilla; Atak, Mehtap (2023)Cisplatin (Cis) is an important chemotherapeutic agent used in cancer treatment. Males exposed to Cis were reported to exhibit testicular toxicity. Cis-induced testicular toxicity is mediated by oxidative stress, inflammation, ... -
Evaluation of the protective effect of coenzyme Q10 against x-ray irradiation-induced ovarian injury
Tekin, Yeşim Bayoğlu; Tümkaya, Levent; Mercantepe, Tolga; Topal, Zehra Suzan; Samancı, Tuğba Çelik; Yılmaz, Hülya Kılıç; Rakıcı, Sema Yılmaz; Topçu, Atilla (Wiley, 2024)Aim: This study focused on the anti-oxidant and anti-apoptotic effects of CoQ10 in ovaries exposed to pelvic radiation. Methods: Thirty-two female rats were randomly assigned into four groups. Group I (control group), Group ... -
Hepatic effects of ketamine administration for 2 weeks in rats
Kalkan, Yıldıray; Tomak, Yakup; Altuner, Durdu; Tümkaya, Levent; Bostan, Habib; Yılmaz, Adnan; Ünal, D.; Kara, A.; Turan, A. (Sage Publishing, 2014)The aim of the present study was to investigate the long-term and high-dose application of ketamine on the liver by employing histologic and biochemical methods. A total of 30 male rats were randomly assigned to control ... -
Histopathological evaluation of the effects of dexmedetomidine against pituitary damage ınduced by X-ray irradiation
Mercantepe, Filiz; Tümkaya, Levent; Mercantepe, Tolga; Rakıcı, Sema (Taylor & Francis Ltd., 2022)Background: The present study, aimed to investigate the potential negative effects of x-ray radiation and the effects of the α2-adrenergic receptor agonist dexmedetomidine on the pituitary gland. Methods: Twenty-four ... -
The impact of apelin-13 on cisplatin-induced endocrine pancreas damage in rats: an in vivo study
Çiftel, Serpil; Tümkaya, Levent; Saral, Sinan; Mercantepe, Tolga; Akyıldız, Kerimali; Yılmaz, Adnan; Mercantepe, Tolga (Springer, 2024)Apelin-13 is a peptide hormone that regulates pancreatic endocrine functions, and its benefits on the endocrine pancreas are of interest. This study aims to investigate the potential protective effects of apelin-13 in ... -
Infliximab modulates cisplatin-induced hepatotoxicity in rats
Cüre, Medine Cumhur; Cüre, Erkan; Kalkan, Yıldıray; Kırbaş, Aynur; Tümkaya, Levent; Yılmaz, Arif; Türkyılmaz, Ayşegül Küçükali; Sehitoğlu, İbrahim; Yüce, Süleyman (Galenos Publ, 2016)Background: Cisplatin (Cis) is one of the most com-monly used antineoplastic drugs. It is used as chemo-therapy for many solid organ malignancies such as brain, neck, male and female urogenital, vesical and pulmonary ... -
Influence of infliximab pretreatment on ischemia/reperfusion injury in rat intestine
Akdoğan, Remzi Adnan; Kalkan, Yıldıray; Tümkaya, Levent; Alacam, Hasan; Erdivanlı, Başar; Aydın, İbrahim (Via Medica, 2014)The Pringle maneuver is used in hepatic surgery to prevent blood loss but is associated with ischemia-reperfusion injury. To investigate the effect of infliximab on inflammation and apoptosis in rat intestinal mucosa during ... -
An investigation of the effects of metformin on ovarian ischemia-reperfusion injury in rats
Topçu, Atilla; Balık, Gülşah; Atak, Mehtap; Mercantepe, Tolga; Uydu, Hüseyin Avni; Tümkaya, Levent (Elsevier, 2019)Damage to the ovaries or tissue torsion can significantly reduce the ovarian reserve and thus cause severe gynecological and hormonal deficiencies. the discovery of new agents is always needed in the treatment of this ... -
An investigation of the effects of N-acetylcysteine on radiotherapy-induced testicular injury in rats
Topçu, Atilla; Mercantepe, Filiz; Rakıcı, Sema; Tümkaya, Levent; Uydu, Hüseyin Avni; Mercantepe, Tolga (Springer, 2019)According to data issued by the International Agency for Research on Cancer in 2012, the estimated number of new cases of all types of cancer worldwide was estimated to exceed 10 million, and 6 million of whom receive ... -
Is adalimumab protective in ischemia‐reperfusion injury in lung?
Kurt, Aysel; Tümkaya, Levent; Kalkan, Yıldıray; Türüt, Hasan; Cüre, Medine Cumhur; Cüre, Erkan; Şehitoğlu, İbrahim; Bilgin, Hacer; Usta, Mustafa (Mashhad University of Medical Sciences, 2015)Objective(s): Increasing cytokines and reactive oxygen species (ROS) during ischemia reperfusion (I?R) leads to the lung damage. Adalimumab (Ada) is a potent tumor necrosis factor?alpha (TNF??) inhibitor agent. We aimed ... -
Long-term protective effects of lamotrigine in a rat ovarian ischemia-reperfusion model
Aktepe, Rıza; Üçüncü, Yılmaz; Tümkaya, Levent; Mercantepe, Tolga; Topçu, Atilla; Uydu, Hüseyin Avni; Atak, Mehtap (Elsevier, 2024)Ovarium torsion is a gynecological emergency that is common in women of reproductive age and requires early diagnosis and intervention. In this study, we aimed to investigate the long-term anatomical, histological and ...