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dc.contributor.authorÇetiz, Mehmet Veysi
dc.contributor.authorYagi, Sakina
dc.contributor.authorKurt, Ümran
dc.contributor.authorKoyuncu, İsmail
dc.contributor.authorYüksekdağ, Özgür
dc.contributor.authorCaprioli, Giovanni
dc.contributor.authorAcquaticci, Laura
dc.contributor.authorAngeloni, Simone
dc.contributor.authorŞenkardeş, İsmail
dc.contributor.authorZengin, Gökhan
dc.date.accessioned2025-01-10T07:28:18Z
dc.date.available2025-01-10T07:28:18Z
dc.date.issued2024en_US
dc.identifier.citationCetiz, M. V., Yagi, S., Kurt, U., Koyuncu, I., Yuksekdag, O., Caprioli, G., Acquaticci, L., Angeloni, S., Senkardes, I., & Zengin, G. (2024). Bridging HPLC‐ESI‐MS/MS analysis and in vitro biological activity assay through molecular docking and network pharmacology: The example of European nettle tree (Celtis australis L.). eFood, 5(6), e70026. https://doi.org/10.1002/efd2.70026en_US
dc.identifier.issn2666-3066
dc.identifier.urihttps://doi.org/10.1002/efd2.70026
dc.identifier.urihttps://hdl.handle.net/11436/9846
dc.description.abstractCeltis australis L. (Family: Cannabaceae) is commonly used to treat many diseases like gastrointestinal problems, menstrual bleeding and amenorrhea. The present study was designed to investigate the chemical constituents, antioxidant, enzyme inhibitory and cytotoxic properties of different extracts from twigs, fruits and leaves of C. australis. EtOAc, EtOH, 70% EtOH and aqueous extracts were prepared by maceration. Results showed that the EtOH extract of the leaves had the highest total phenolic content and possessed remarkable antiradical, ion reducing and total antioxidant activities. Additionally, the leaves (EtOH or EtOAc extracts) exerted the best enzyme inhibition properties. The polar extracts of the leaves had significant cytotoxic effect against the human colorectal adenocarcinoma (HT-29) and human prostate cancer (DU-145) cell lines while the EtOAc of the twigs was effective against the former cell line. Phytochemically, the twigs and fruits accumulated high content of vanillic acid, 4-hydroxy benzoic acid and syringic acid. Through a combination of in vitro and in silico approaches, we identified key phytochemicals exhibited significant inhibitory effects on several cancer-related proteins, through in vitro and in silico approaches that show significant inhibition of cancer-related proteins. In conclusion, these findings indicated that C. australis could be a promising source of bioactive molecules for food, pharmaceutical and cosmetic industries.en_US
dc.language.isoengen_US
dc.publisherWileyen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAntioxidanten_US
dc.subjectBioactive agentsen_US
dc.subjectCeltis australisen_US
dc.subjectEnzyme inhibitionen_US
dc.subjectNetwork pharmacologyen_US
dc.subjectSolvent extractsen_US
dc.titleBridging HPLC-ESI-MS/MS analysis and in vitro biological activity assay through molecular docking and network pharmacology: The example of European nettle tree (Celtis australis L.)en_US
dc.typearticleen_US
dc.contributor.departmentRTEÜ, Fen - Edebiyat Fakültesi, Kimya Bölümüen_US
dc.contributor.institutionauthorKurt, Ümran
dc.identifier.doi10.1002/efd2.70026en_US
dc.identifier.volume5en_US
dc.identifier.issue6en_US
dc.identifier.startpagee70026en_US
dc.relation.journaleFooden_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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