Oral–systemic health interactions in dentistry: a 25-year bibliometric and thematic mapping analysis

Abstract

Aim: This study aimed to conduct a 25-year bibliometric and thematic mapping analysis to explore how the scientific literature linking oral health and systemic diseases has evolved, focusing on major trends, diagnostic developments, and emerging interdisciplinary directions. Materials and Methods: Publications indexed in the Web of Science Core Collection (2000–October 2025) under “Dentistry and Oral Medicine” were analyzed using the Biblioshiny R package and VOSviewer. Annual scientific output, citation trends, contributing countries, journals, and keyword-based thematic structures were evaluated. Results: A total of 2650 articles met the inclusion criteria. Global research output showed a steady increase, with a marked surge after 2015. The United States, China, Brazil, and England were the most productive countries, while several European nations demonstrated the highest citation impact. Periodontology journals dominated publication volume; however, recent years revealed diversification toward endodontic, peri-implant, and oral oncology topics. Thematic evolution maps indicated a transition from periodontal inflammation–oriented research themes to broader mechanistic perspectives. Conclusions: Oral–systemic health research has shifted from a periodontally centered field to a broader interdisciplinary domain integrating molecular, microbiological, and translational approaches. While significant progress has been achieved, future studies should focus on underexplored areas such as endodontic pathology, surgical interventions, and orthodontic influences to achieve a comprehensive understanding of oral contributions to systemic health.