dc.contributor.author | Kostakoğlu, Uğur | |
dc.contributor.author | Mercantepe, Tolga | |
dc.contributor.author | Yılmaz, Hülya Kılıç | |
dc.contributor.author | Tümkaya, Levent | |
dc.contributor.author | Batçık, Şule | |
dc.contributor.author | Pınarbaş, Esra | |
dc.contributor.author | Uydu, Hüseyin Avni | |
dc.date.accessioned | 2020-12-19T19:34:17Z | |
dc.date.available | 2020-12-19T19:34:17Z | |
dc.date.issued | 2021 | |
dc.identifier.citation | Kostakoglu, U., Mercantepe, T., Yilmaz, H.K., Tumkaya, L., Batcik, S., Pinarbas, E., Uydu, H.A. (2021). The protective effects of perindopril against acute kidney damage caused by septic shock. Inflammation, 44(1), 148-159. https://doi.org/10.1007/s10753-020-01316-8 | en_US |
dc.identifier.issn | 0360-3997 | |
dc.identifier.issn | 1573-2576 | |
dc.identifier.uri | https://doi.org/10.1007/s10753-020-01316-8 | |
dc.identifier.uri | https://hdl.handle.net/11436/1039 | |
dc.description | mercantepe, tolga/0000-0002-8506-1755 | en_US |
dc.description | WOS: 000560266500001 | en_US |
dc.description | PubMed: 32803666 | en_US |
dc.description.abstract | Acute kidney injury (AKI) resulting from septic shock caused by sepsis is an important health problem encountered at rates of 55-73%. Increasing oxidative stress and inflammation following sepsis is a widely observed condition with rising mortality rates. the purpose of this study was to determine whether perindopril (PER) can prevent sepsis-associated AKI with its antioxidant, anti-inflammatory, and anti-apoptotic effects. the control group received an oral saline solution only for 4 days. Cecal ligation and puncture (CLP)-induced sepsis only was applied to the CLP group, while the CLP + PER (2 mg/kg) received CLP-induced sepsis together with 2 mg/kg PER via the oral route for 4 days before induction of sepsis. Finally, all rats were euthanized by anesthesia and sacrificed. TBARS, total SH levels and NF-kappa beta, TNF-alpha, and Caspase-3 expression were then calculated for statistical analysis. TBARS, total SH, NF-k beta/p65, TNF-a, and Caspase-3 levels increased in the CLP group. in contrast, oral administration of PER (2 mg/kg) to septic rats reduced TBARS levels and NF-k beta/p65, TNF-alpha, and Caspase-3 immunopositivity at biochemical analysis. PER treatment appears to be a promising method for preventing sepsis-induced acute kidney injury through its antioxidant anti-inflammation and anti-apoptotic activities. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Springer/Plenum Publishers | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Inflammation | en_US |
dc.subject | Kidney | en_US |
dc.subject | Oxidative stress | en_US |
dc.subject | Perindopril | en_US |
dc.subject | Rat | en_US |
dc.subject | Sepsis | en_US |
dc.title | The protective effects of perindopril against acute kidney damage caused by septic shock | en_US |
dc.type | article | en_US |
dc.contributor.department | RTEÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü | en_US |
dc.contributor.institutionauthor | Kostakoğlu, Uğur | |
dc.contributor.institutionauthor | Mercantepe, Tolga | |
dc.contributor.institutionauthor | Yılmaz, Hülya Kılıç | |
dc.contributor.institutionauthor | Tümkaya, Levent | |
dc.contributor.institutionauthor | Batçık, Şule | |
dc.contributor.institutionauthor | Pınarbaş, Esra | |
dc.contributor.institutionauthor | Uydu, Hüseyin Avni | |
dc.identifier.doi | 10.1007/s10753-020-01316-8 | |
dc.relation.journal | Inflammation | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |