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dc.contributor.authorKostakoğlu, Uğur
dc.contributor.authorMercantepe, Tolga
dc.contributor.authorYılmaz, Hülya Kılıç
dc.contributor.authorTümkaya, Levent
dc.contributor.authorBatçık, Şule
dc.contributor.authorPınarbaş, Esra
dc.contributor.authorUydu, Hüseyin Avni
dc.date.accessioned2020-12-19T19:34:17Z
dc.date.available2020-12-19T19:34:17Z
dc.date.issued2021
dc.identifier.citationKostakoglu, U., Mercantepe, T., Yilmaz, H.K., Tumkaya, L., Batcik, S., Pinarbas, E., Uydu, H.A. (2021). The protective effects of perindopril against acute kidney damage caused by septic shock. Inflammation, 44(1), 148-159. https://doi.org/10.1007/s10753-020-01316-8en_US
dc.identifier.issn0360-3997
dc.identifier.issn1573-2576
dc.identifier.urihttps://doi.org/10.1007/s10753-020-01316-8
dc.identifier.urihttps://hdl.handle.net/11436/1039
dc.descriptionmercantepe, tolga/0000-0002-8506-1755en_US
dc.descriptionWOS: 000560266500001en_US
dc.descriptionPubMed: 32803666en_US
dc.description.abstractAcute kidney injury (AKI) resulting from septic shock caused by sepsis is an important health problem encountered at rates of 55-73%. Increasing oxidative stress and inflammation following sepsis is a widely observed condition with rising mortality rates. the purpose of this study was to determine whether perindopril (PER) can prevent sepsis-associated AKI with its antioxidant, anti-inflammatory, and anti-apoptotic effects. the control group received an oral saline solution only for 4 days. Cecal ligation and puncture (CLP)-induced sepsis only was applied to the CLP group, while the CLP + PER (2 mg/kg) received CLP-induced sepsis together with 2 mg/kg PER via the oral route for 4 days before induction of sepsis. Finally, all rats were euthanized by anesthesia and sacrificed. TBARS, total SH levels and NF-kappa beta, TNF-alpha, and Caspase-3 expression were then calculated for statistical analysis. TBARS, total SH, NF-k beta/p65, TNF-a, and Caspase-3 levels increased in the CLP group. in contrast, oral administration of PER (2 mg/kg) to septic rats reduced TBARS levels and NF-k beta/p65, TNF-alpha, and Caspase-3 immunopositivity at biochemical analysis. PER treatment appears to be a promising method for preventing sepsis-induced acute kidney injury through its antioxidant anti-inflammation and anti-apoptotic activities.en_US
dc.language.isoengen_US
dc.publisherSpringer/Plenum Publishersen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectInflammationen_US
dc.subjectKidneyen_US
dc.subjectOxidative stressen_US
dc.subjectPerindoprilen_US
dc.subjectRaten_US
dc.subjectSepsisen_US
dc.titleThe protective effects of perindopril against acute kidney damage caused by septic shocken_US
dc.typearticleen_US
dc.contributor.departmentRTEÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.contributor.institutionauthorKostakoğlu, Uğur
dc.contributor.institutionauthorMercantepe, Tolga
dc.contributor.institutionauthorYılmaz, Hülya Kılıç
dc.contributor.institutionauthorTümkaya, Levent
dc.contributor.institutionauthorBatçık, Şule
dc.contributor.institutionauthorPınarbaş, Esra
dc.contributor.institutionauthorUydu, Hüseyin Avni
dc.identifier.doi10.1007/s10753-020-01316-8
dc.relation.journalInflammationen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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