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dc.contributor.authorTelatar, Gül Yıldız
dc.contributor.authorSaydam, Faruk
dc.contributor.authorGüzel, Ali İrfan
dc.contributor.authorTelatar, Barış Can
dc.date.accessioned2020-12-19T19:34:18Z
dc.date.available2020-12-19T19:34:18Z
dc.date.issued2020
dc.identifier.citationYıldız Telatar, G., Saydam, F., Güzel, A. İ., & Telatar, B. C. (2020). Variants in taste genes on caries risk and caries activity status. Medical molecular morphology, 53(4), 244–251. https://doi.org/10.1007/s00795-020-00263-5en_US
dc.identifier.issn1860-1480
dc.identifier.issn1860-1499
dc.identifier.urihttps://doi.org/10.1007/s00795-020-00263-5
dc.identifier.urihttps://hdl.handle.net/11436/1044
dc.descriptionWOS: 000557110000001en_US
dc.descriptionPubMed: 32770263en_US
dc.description.abstractThe aim of this study was to evaluate the role of taste-related gene polymorphisms (CA6,TAS1R1,TAS1R3, TLR2,andTLR4)on dental caries and caries activity in adults. Individuals aged 25-44 years included in the study were assigned to two groups according to the decayed-missing-filled teeth index (DMFT) as the high caries risk (DMFT >= 14,n = 100) and the low caries risk (DMFT <= 5,n = 100). TaqMan allelic discrimination assays were used for genotyping the gene variants after isolating the DNA from the buccal smears. According to the American dental association caries classification system (ADA CCS), all teeth were scored as initial, moderate or advanced caries. the variant of the gustin (CA6) in saliva was found to be associated with a high caries risk (CA6rs17032907,P < .001). There was also a statistically significant difference in the dominant model of the same variant (CC vs. TT:P < .001, OR = 5.05, 95% CI: 2.38-10.71). the presence of genotype CC and allele C was less frequent in the advanced caries lesion group (P < .001). This study shows that theCA6rs17032907 gene variant may be a risk factor for dental caries affecting caries activity. Clinical Trials ID: NCT04066101.en_US
dc.description.sponsorshipRecep Tayyip Erdogan University Scientific Research Projects Foundation [TSA-2017-772]en_US
dc.description.sponsorshipThe study was supported by the Recep Tayyip Erdogan University Scientific Research Projects Foundation (TSA-2017-772).en_US
dc.language.isoengen_US
dc.publisherSpringer Japan Kken_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDental cariesen_US
dc.subjectGene variantsen_US
dc.subjectTasteen_US
dc.subjectGustinen_US
dc.subjectCaries activityen_US
dc.titleVariants in taste genes on caries risk and caries activity statusen_US
dc.typearticleen_US
dc.contributor.departmentRTEÜ, Diş Hekimliği Fakültesi, Klinik Bilimler Bölümüen_US
dc.contributor.institutionauthorTelatar, Gül Yıldız
dc.contributor.institutionauthorSaydam, Faruk
dc.contributor.institutionauthorGüzel, Ali İrfan
dc.identifier.doi10.1007/s00795-020-00263-5
dc.identifier.volume53en_US
dc.identifier.issue4en_US
dc.identifier.startpage244en_US
dc.identifier.endpage251en_US
dc.relation.journalMedical Molecular Morphologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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