dc.contributor.author | Gürlek, Beril | |
dc.contributor.author | Yılmaz, Adnan | |
dc.contributor.author | Durakoğlugil, Murtaza Emre | |
dc.contributor.author | Karakaş, Sibel | |
dc.contributor.author | Kazaz, İlknur M. | |
dc.contributor.author | Önal, Özgür | |
dc.contributor.author | Şatıroğlu, Ömer | |
dc.date.accessioned | 2020-12-19T19:35:37Z | |
dc.date.available | 2020-12-19T19:35:37Z | |
dc.date.issued | 2020 | |
dc.identifier.citation | Gürlek, B., Yılmaz, A., Durakoğlugil, M. E., Karakaş, S., Kazaz, İ. M., Önal, Ö., & Şatıroğlu, Ö. (2020). Evaluation of serum apelin-13 and apelin-36 concentrations in preeclamptic pregnancies. The journal of obstetrics and gynaecology research, 46(1), 58–65. https://doi.org/10.1111/jog.14137 | en_US |
dc.identifier.issn | 1341-8076 | |
dc.identifier.issn | 1447-0756 | |
dc.identifier.uri | https://doi.org/10.1111/jog.14137 | |
dc.identifier.uri | https://hdl.handle.net/11436/1318 | |
dc.description | onal, ozgur/0000-0001-6514-2120; GURLEK, BERIL/0000-0002-4050-3193 | en_US |
dc.description | WOS: 000505271900006 | en_US |
dc.description | PubMed: 31595589 | en_US |
dc.description.abstract | Aim Recent studies suggest that apelin can be a novel potential therapeutic mediator to improve the diagnosis, and treatment of preeclampsia. This study aimed to investigate the association of serum apelin-13 and apelin-36 with preeclampsia and to detect their relationship with preeclampsia-associated perinatal morbidity. Methods Forty-four women with preeclampsia were included as the study group. Forty-four healthy pregnant women, at similar gestational week with similar gravidity, formed the control group. the clinical findings, biochemical indicators, maternal and perinatal outcomes, and the serum concentrations of apelin-36 and apelin-13 were evaluated. the levels of apelin-13 and apelin-36 were determined with commercial kits using a competition-based enzyme-linked immunosorbent assay method. Results the mean gestational age at sampling was 35.77 +/- 2.515 weeks in the preeclamptic group, 36.45 +/- 2.057 weeks in the control group (P = 0.270). Maternal serum apelin-36 and apelin-13 concentrations were significantly lower in patients with preeclampsia compared to the individuals in the control group (P = 0.030 and P = 0.005, respectively). the optimal cut-off points of apelin-36 and apelin-13 measurements for discriminating between preeclampsia and controls were evaluated by the receiver-operator curve analysis. the results showed that apelin-13 and apelin-36 are moderately successful markers to differentiate subjects with preeclampsia from healthy pregnant women. the concentrations of apelin-13 and apelin-36 in both groups were not statistically different in cases with and without adverse fetal/neonatal outcomes. Conclusion in conclusion, we investigated serum apelin-13 and apelin-36 concentrations in preeclamptic patients and demonstrated markedly lower maternal concentrations compared to healthy pregnant women. | en_US |
dc.description.sponsorship | Recep Tayyip Erdogan University Scientific Research CommitteeRecep Tayyip Erdogan University [TSA-2017-785] Funding Source: Medline | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Wiley | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Apelin-13 | en_US |
dc.subject | Apelin-36 | en_US |
dc.subject | Neonatal outcome | en_US |
dc.subject | Perinatal morbidity | en_US |
dc.subject | Preeclampsia | en_US |
dc.title | Evaluation of serum apelin-13 and apelin-36 concentrations in preeclamptic pregnancies | en_US |
dc.type | article | en_US |
dc.contributor.department | RTEÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü | en_US |
dc.contributor.institutionauthor | Gürlek, Beril | |
dc.contributor.institutionauthor | Yılmaz, Adnan | |
dc.contributor.institutionauthor | Durakoğlugil, Murtaza Emre | |
dc.contributor.institutionauthor | Karakaş, Sibel | |
dc.contributor.institutionauthor | Kazaz, İlknur M. | |
dc.contributor.institutionauthor | Şatıroğlu, Ömer | |
dc.identifier.doi | 10.1111/jog.14137 | |
dc.identifier.volume | 46 | en_US |
dc.identifier.issue | 1 | en_US |
dc.identifier.startpage | 58 | en_US |
dc.identifier.endpage | 65 | en_US |
dc.ri.edit | oa | en_US |
dc.relation.journal | Journal of Obstetrics and Gynaecology Research | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |