dc.contributor.author | Menteşe, Emre | |
dc.contributor.author | Baltaş, Nimet | |
dc.contributor.author | Bekircan, Olcay | |
dc.date.accessioned | 2020-12-19T19:36:04Z | |
dc.date.available | 2020-12-19T19:36:04Z | |
dc.date.issued | 2019 | |
dc.identifier.citation | Menteşe, E., Baltaş, N. & Bekircan, O. (2019). Synthesis and kinetics studies of N '-(2-(3,5-disubstituted-4H-1,2,4-triazol-4-yl)acetyl)-6/7/8-substituted-2-oxo-2H-chromen-3-carbohydrazide derivatives as potent antidiabetic agents. Archiv Der Pharmazie, 352(12), e1900227. https://doi.org/10.1002/ardp.201900227 | en_US |
dc.identifier.issn | 0365-6233 | |
dc.identifier.issn | 1521-4184 | |
dc.identifier.uri | https://doi.org/10.1002/ardp.201900227 | |
dc.identifier.uri | https://hdl.handle.net/11436/1390 | |
dc.description | WOS: 000490073000001 | en_US |
dc.description | PubMed: 31609028 | en_US |
dc.description.abstract | A novel series of N '-(2-(3,5-disubstituted-4H-1,2,4-triazol-4-yl)acetyl)-6/7/8-substituted-2-oxo-2H-chromen-3-carbohydrazides were synthesized and studied for their alpha-glucosidase inhibition activity. Most of the synthesized compounds exhibited potential alpha-glucosidase inhibition activity with IC50 values ranging from 0.96 +/- 0.02 to 32.86 +/- 0.73 mu g/ml. Among them, compounds 3e and 4e, having a methoxy group on the coumarin ring, proved to be the most potent ones, showing an enzyme inhibition activity with IC50 = 0.96 +/- 0.02 and 1.44 +/- 0.06 mu g/ml, respectively. the kinetic study through Lineweaver-Burk plots revealed that the inhibition mechanism of the most active compounds 3d, 3e, 4d, and 4e, on the alpha-glucosidase activity, was found to be in the competitive mode. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Wiley-V C H Verlag Gmbh | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | 1 | en_US |
dc.subject | 2 | en_US |
dc.subject | 4-triazole | en_US |
dc.subject | Coumarin | en_US |
dc.subject | Kiinetic study | en_US |
dc.subject | Alpha-glucosidase inhibition | en_US |
dc.title | Synthesis and kinetics studies of N '-(2-(3,5-disubstituted-4H-1,2,4-triazol-4-yl)acetyl)-6/7/8-substituted-2-oxo-2H-chromen-3-carbohydrazide derivatives as potent antidiabetic agents | en_US |
dc.type | article | en_US |
dc.contributor.department | RTEÜ, Fen - Edebiyat Fakültesi, Kimya Bölümü | en_US |
dc.contributor.institutionauthor | Menteşe, Emre | |
dc.contributor.institutionauthor | Baltaş, Nimet | |
dc.identifier.doi | 10.1002/ardp.201900227 | |
dc.identifier.volume | 352 | en_US |
dc.identifier.issue | 12 | en_US |
dc.relation.journal | Archiv Der Pharmazie | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |