dc.contributor.author | Menteşe, Emre | |
dc.contributor.author | Sökmen, Bahar Bilgin | |
dc.date.accessioned | 2020-12-19T19:36:45Z | |
dc.date.available | 2020-12-19T19:36:45Z | |
dc.date.issued | 2019 | |
dc.identifier.citation | Menteşe, E. & Sökmen, B.B. (2019). Synthesis and In Vitro Urease Inhibition of Some Novel Benzimidazole-based Hydrazones. Journal of Heterocyclic Chemistry, 56(9), 2442-2448. https://doi.org/10.1002/jhet.3632 | en_US |
dc.identifier.issn | 0022-152X | |
dc.identifier.issn | 1943-5193 | |
dc.identifier.uri | https://doi.org/10.1002/jhet.3632 | |
dc.identifier.uri | https://hdl.handle.net/11436/1474 | |
dc.description | WOS: 000479700000001 | en_US |
dc.description.abstract | A novel series of N '-(substituted benzylidene)-2-(5,6-dichloro-2-methyl-1H-benzimidazol-1-yl)acetohydrazides and N '-(1-(substituted phenyl)ethylidene)-2-(5,6-dichloro-2-methyl-1H-benzimidazol-1-yl)acetohydrazides were synthesized and then studied for their urease inhibitory activities using thiourea as a standard drug. All newly synthesized compounds were found to exhibit potent inhibitory properties against urease enzyme in the range of IC50 = 0.0155 +/- 0.0039-0.0602 +/- 0.0071 mu M, when compared with the thiourea as standard (IC50 = 0.5115 +/- 0.0233 mu M). All target molecules were characterized by H-1-NMR, C-13-NMR, IR, and electrospray ionization mass spectrometry. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Wiley | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Molecular docking | en_US |
dc.title | Synthesis and in vitro urease inhibition of some novel benzimidazole-based hydrazones | en_US |
dc.type | article | en_US |
dc.contributor.department | RTEÜ, Fen - Edebiyat Fakültesi, Kimya Bölümü | en_US |
dc.contributor.institutionauthor | Menteşe, Emre | |
dc.identifier.doi | 10.1002/jhet.3632 | |
dc.identifier.volume | 56 | en_US |
dc.identifier.issue | 9 | en_US |
dc.identifier.startpage | 2442 | en_US |
dc.identifier.endpage | 2448 | en_US |
dc.relation.journal | Journal of Heterocyclic Chemistry | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |