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dc.contributor.authorOzdemir, Dogukan
dc.contributor.authorOzgur, Abdulkadir
dc.contributor.authorKalkan, Yildiray
dc.contributor.authorTerzi, Suat
dc.contributor.authorTumkaya, Levent
dc.contributor.authorYilmaz, Adnan
dc.contributor.authorDursun, Engin
dc.date.accessioned2020-12-19T19:40:56Z
dc.date.available2020-12-19T19:40:56Z
dc.date.issued2019
dc.identifier.issn1808-8694
dc.identifier.issn1808-8686
dc.identifier.urihttps://doi.org/10.1016/j.bjorl.2017.10.009
dc.identifier.urihttps://hdl.handle.net/11436/1691
dc.descriptionyilmaz, adnan/0000-0003-4842-1173en_US
dc.descriptionWOS: 000454726000010en_US
dc.descriptionPubMed: 29174583en_US
dc.description.abstractIntroduction: Cisplatin is one of the main chemotherapeutic agents used for the treatment of many types of cancer. However, ototoxicity, one of the most serious side effects of cisplatin, extract restricts its usage. Objective: We aimed to investigate the protective effects of whortleberry extract against cisplatin-induced ototoxicity by evaluating hearing and histopathological cochlear damage and by measuring the biochemical parameters affected byoxidative stress. Methods: Forty-eight male rats were included in the study after performing Distortion Product Otoacoustic Emission test to confirm that their hearing levels were normal. the rats were randomly divided into six groups: the control group, the sham group, and, which received only whortleberry extract, only cisplatin, cisplatin + 100 mg whortleberry extract, cisplatin + 200 mg whortleberry extract, respectively. Audiologic investigation was performed by performing the Distortion Product Otoacoustic Emission test at the beginning and at the eighth day of the study. Cardiac blood samples were collected for biochemical analysis, and the rats were sacrificed to obtain cochlear histopathological specimens on the eighth day. Results: the results revealed that whortleberry protects hearing against cisplatin-induced ototoxicity independent of the dose. However, high doses of whortleberry extract are needed to prevent histopathological degeneration and oxidative stress. Conclusion: the results obtained in this study show that whortleberry extract has a protective effect against cisplatin-induced ototoxicity. (C) 2017 Associacao Brasileira de Otorrinolaringologia e Cirurgia Cervico-Facial. Published by Elsevier Editora Ltda.en_US
dc.description.sponsorshipRecep Tayyip Erdogan University Scientific Research Project Unit (RTEUBAP) [2015/9]en_US
dc.description.sponsorshipThis work was supported by Recep Tayyip Erdogan University Scientific Research Project Unit (RTEUBAP) under the project number of 2015/9. Compliance with ethical standards; the study was performed in accordance with the 2011 Guide for the Care and Use of Laboratory Animals.en_US
dc.language.isoengen_US
dc.publisherAssoc Brasileira Otorrinolaringologia & Cirurgia Cervicofacialen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectOtotoxicityen_US
dc.subjectCisplatinen_US
dc.subjectWhorleberry extracten_US
dc.titleThe protective effects of whortleberry extract against cisplatin-induced ototoxicity in ratsen_US
dc.typearticleen_US
dc.contributor.departmentRTEÜen_US
dc.identifier.doi10.1016/j.bjorl.2017.10.009
dc.identifier.volume85en_US
dc.identifier.issue1en_US
dc.identifier.startpage55en_US
dc.identifier.endpage62en_US
dc.ri.editoaen_US
dc.relation.journalBrazilian Journal of Otorhinolaryngologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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