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dc.contributor.authorBalik, Mehmet Sabri
dc.contributor.authorTumkaya, Levent
dc.contributor.authorMercantepe, Tolga
dc.contributor.authorYilmaz, Adnan
dc.contributor.authorBalik, Gulsah
dc.contributor.authorTopcu, Atilla
dc.contributor.authorYazici, Zihni
dc.date.accessioned2020-12-19T19:41:24Z
dc.date.available2020-12-19T19:41:24Z
dc.date.issued2018
dc.identifier.issn2074-1804
dc.identifier.issn2074-1812
dc.identifier.urihttps://doi.org/10.5812/ircmj.66319
dc.identifier.urihttps://hdl.handle.net/11436/1770
dc.descriptionMercantepe, Tolga/0000-0002-8506-1755en_US
dc.descriptionWOS: 000447663100003en_US
dc.description.abstractBackground: Even though Cisplatin (Cis) is known to be organotoxic, it is used in neoplastic chemotherapy. in skeletal muscles, the toxic effect manifests as atrophy. Objectives: the tea grape extract (TGE) is a sort of whortleberry that has various physiological effects including prevention of chemically induced cellular insults. Therefore, we examined if the TGE has a protective effect against the Cis induced skeletal muscle atrophy. Methods: Female Sprague-Dawley rats were used in this animal experimental study. Rats were allocated into different study groups, each with eight members. the groups comprised control, solvent control, 200 mg TGE, Cis, Cis + 100 mg TGE, and Cis + 200 mg TGE. Results: the mean fiber area of the skeletal muscle (MFASM) decreased significantly in the Cis group in comparison to the control group (P = 0.01). MFASM showed similarities between the Cis + TGE 200 and control groups (P > 0.05, P = 0.418). Similarities were also observed for MFASM between the Cis + 100 mg TGE and Cis + 200 mg TGE groups (P > 0.05, P = 0.891). the mean serum calcium level in the Cis group (10.26 +/- 0.29) was significantly higher in TGE 100 (9.13 +/- 0.11) and TGE 200 groups (9.21 +/- 0.13). Conclusions: It is concluded that the tea grape extract has a protective effect on Cis-induced toxicity of the skeletal muscles.en_US
dc.language.isoengen_US
dc.publisherKowsar Publen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAtrophyen_US
dc.subjectChemotherapyen_US
dc.subjectCisplatinen_US
dc.subjectMyofibroblasten_US
dc.subjectMuscleen_US
dc.subjectPlant Extractsen_US
dc.subjectSkeletalen_US
dc.subjectTea Grape Extracten_US
dc.titleProtective Effect of Tea Grape Extract on Cisplatin-Induced Muscle Atrophy: A Morphological Studyen_US
dc.typearticleen_US
dc.contributor.departmentRTEÜen_US
dc.identifier.doi10.5812/ircmj.66319
dc.identifier.volume20en_US
dc.identifier.issue9en_US
dc.ri.editoaen_US
dc.relation.journalIranian Red Crescent Medical Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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