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dc.contributor.authorÇeliker, Fatma Beyazal
dc.contributor.authorTümkaya, Levent
dc.contributor.authorYılmaz, Adnan
dc.contributor.authorCoşkun, Zerrin Özergin
dc.contributor.authorÇeliker, Metin
dc.contributor.authorOğhan, Fatih
dc.contributor.authorMercantepe, Tolga
dc.contributor.authorTerzi, Suat
dc.contributor.authorDursun, Engin
dc.date.accessioned2020-12-19T19:41:45Z
dc.date.available2020-12-19T19:41:45Z
dc.date.issued2018
dc.identifier.citationCeliker, F. B., Tumkaya, L., Yilmaz, A., Coskun, Z. O., Celiker, M., Oghan, F., Mercantepe, T., Terzi, S., & Dursun, E. (2018). Effects of gadolinium-based contrast agents on submandibular gland tissue in rats. European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 275(6), 1641–1647. https://doi.org/10.1007/s00405-018-4959-7en_US
dc.identifier.issn0937-4477
dc.identifier.issn1434-4726
dc.identifier.urihttps://doi.org/10.1007/s00405-018-4959-7
dc.identifier.urihttps://hdl.handle.net/11436/1825
dc.descriptionMercantepe, Tolga/0000-0002-8506-1755; yilmaz, adnan/0000-0003-4842-1173en_US
dc.descriptionWOS: 000432207000033en_US
dc.descriptionPubMed: 29605866en_US
dc.description.abstractThe aim of this prospective animal study is to investigate the influence of multiple administrations of macrocyclic ionic (gadoteric acid) and linear nonionic (gadodiamide) gadolinium-based contrast agents (GBCA) on submandibular gland tissue (SGT) of the rats. Twenty-four Sprague Dawley female rats were included the study. Group 1 was determined as a control group (n = 6). Group 2 was determined as saline group (n = 6). Group 3 was determined as Omniscan group (n = 6) and received only intraperitoneal (IP) 0.1 mmol (0.2 mL/kg)/kg gadodiamide for 8 days. Group 4 was determined as Dotarem group (n = 6) and received only IP 0.1 mmol (0.2 mL/kg)/mg/kg gadoteric acid daily for 8 days. on the 9th day of the administration, the rats were sedated with ketamine and xylazine through IP injection. the right SGT was removed after sedation. Histopathological and immunohistochemical changes in SGT were evaluated. the SGT of the Omniscan and Dotarem groups decreased SGT acini surface area, and serous acinar cells number were observed. on the other hand, no pathology was observed. Mucous acinar cells' caspase-3 positivity for the same markers in Omniscan and Dotarem sections was similar to the control group. However, Omniscan and Dotarem groups serous acinar cells were caspase-3 (+) staining. the intensity of serous acinar cells' caspase-3 (+) for the same markers in Dotarem sections was similar to the Omniscan group. the results also revealed in the analysis of the mean area of the acinus area of the SGT; there were significantly decreased Dotarem group rats when compared to control rats (p < 0.05). We consider that numerical increased apoptosis results arise from repeated doses of GBCAs. Being aware of this effect of the contrast agent may have significance for the chronic sialo-adenitis patients group when used for recurrent contrasted MRI for diagnosis of diseases like MS which requires in follow-up. We should be aware about the frequently contrasted MRI in routine investigations.en_US
dc.language.isoengen_US
dc.publisherSpringeren_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectGadoliniumen_US
dc.subjectSubmandibular glanden_US
dc.subjectContrasten_US
dc.subjectRaten_US
dc.titleEffects of gadolinium-based contrast agents on submandibular gland tissue in ratsen_US
dc.typearticleen_US
dc.contributor.departmentRTEÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.contributor.institutionauthorÇeliker, Fatma Beyazal
dc.contributor.institutionauthorTümkaya, Levent
dc.contributor.institutionauthorYılmaz, Adnan
dc.contributor.institutionauthorCoşkun, Zerrin Özergin
dc.contributor.institutionauthorÇeliker, Metin
dc.contributor.institutionauthorMercantepe, Tolga
dc.contributor.institutionauthorTerzi, Suat
dc.contributor.institutionauthorDursun, Engin
dc.identifier.doi10.1007/s00405-018-4959-7
dc.identifier.volume275en_US
dc.identifier.issue6en_US
dc.identifier.startpage1641en_US
dc.identifier.endpage1647en_US
dc.relation.journalEuropean Archives of Oto-Rhino-Laryngologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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