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dc.contributor.authorMentese, Emre
dc.contributor.authorYilmaz, Fatih
dc.contributor.authorEmirik, Mustafa
dc.contributor.authorUlker, Serdar
dc.contributor.authorKahveci, Bahittin
dc.date.accessioned2020-12-19T19:42:11Z
dc.date.available2020-12-19T19:42:11Z
dc.date.issued2018
dc.identifier.issn0045-2068
dc.identifier.issn1090-2120
dc.identifier.urihttps://doi.org/10.1016/j.bioorg.2017.12.023
dc.identifier.urihttps://hdl.handle.net/11436/1882
dc.descriptionemirik, mustafa/0000-0001-9489-9093en_US
dc.descriptionWOS: 000425897800050en_US
dc.descriptionPubMed: 29306066en_US
dc.description.abstractIn this study, a new series of benzimidazole and bisbenzimidazole derivatives were prepared via the reaction of iminoester hydrochlorides and o-phenylenediamines and then screened for their lipase inhibition properties. Among the synthesized molecules, compounds 7a, 8a and 8c showed the best inhibitory effect against lipase enzyme with IC50 values of 1.72 +/- 0.12 mu M, 1.92 +/- 0.28 and 0.98 +/- 0.07 mu M, respectively. Moreover, molecular modeling studies were performed in order to understand to the inhibitory activity of the molecules. Binding poses of the studied compounds were determined at the target sites using induced fit docking (IFD) algorithms. (C) 2017 Elsevier Inc. All rights reserved.en_US
dc.description.sponsorshipRecep Tayyip Erdogan University Scientific Research Project Unit (BAP)Recep Tayyip Erdogan University [FBA-2016-544]; Recep Tayyip Erdogan UniversityRecep Tayyip Erdogan Universityen_US
dc.description.sponsorshipThe authors declare no conflicts of interest. This work was supported by Recep Tayyip Erdogan University Scientific Research Project Unit (BAP) under project number of FBA-2016-544. Authors thank to Recep Tayyip Erdogan University for this support.en_US
dc.language.isoengen_US
dc.publisherAcademic Press Inc Elsevier Scienceen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBenzimidazoleen_US
dc.subjectBisbenzimidazoleen_US
dc.subjectPiperazineen_US
dc.subjectMebendazoleen_US
dc.subjectLipase inhibitionen_US
dc.subjectMolecular dockingen_US
dc.titleSynthesis, molecular docking and biological evaluation of some benzimidazole derivatives as potent pancreatic lipase inhibitorsen_US
dc.typearticleen_US
dc.contributor.departmentRTEÜen_US
dc.identifier.doi10.1016/j.bioorg.2017.12.023
dc.identifier.volume76en_US
dc.identifier.startpage478en_US
dc.identifier.endpage486en_US
dc.relation.journalBioorganic Chemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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