Basit öğe kaydını göster

dc.contributor.authorKahveci, Bahittin
dc.contributor.authorYılmaz, Fatih
dc.contributor.authorMenteşe, Emre
dc.contributor.authorÜlker, Serdar
dc.date.accessioned2020-12-19T19:48:28Z
dc.date.available2020-12-19T19:48:28Z
dc.date.issued2017
dc.identifier.citationKahveci, B., Yılmaz, F., Menteşe, E., & Ülker, S. (2017). Design, Synthesis, and Biological Evaluation of Coumarin-Triazole Hybrid Molecules as Potential Antitumor and Pancreatic Lipase Agents. Archiv der Pharmazie, 350(8), 10.1002/ardp.201600369. https://doi.org/10.1002/ardp.201600369en_US
dc.identifier.issn0365-6233
dc.identifier.issn1521-4184
dc.identifier.urihttps://doi.org/10.1002/ardp.201600369
dc.identifier.urihttps://hdl.handle.net/11436/2086
dc.descriptionWOS: 000406714000001en_US
dc.descriptionPubMed: 28543820en_US
dc.description.abstractThe design, synthesis, and investigation of antitumor and anti-lipase activities of some coumarin-triazole hybrid molecules are reported. the synthesis of these hybrid molecules was performed under microwave irradiation and conventional heating procedures. the newly synthesized hybrid molecules were investigated as inhibitors against four tumor cell lines (BT20 human breast carcinoma, SK-Mel 128 melanoma, DU-145 prostate carcinoma, and A549 lung carcinoma) and porcine pancreatic lipase (PPL). Most of these compounds showed notable antitumor activities against the tested tumor cell lines, and compounds 8i and 8l showed the best anti-lipase activity of 99.30 +/- 0.56% and 99.85 +/- 1.21%, respectively, at a concentration of 10 mu M.en_US
dc.description.sponsorshipScientific and Technological Research Council of Turkey (TUBITAK)Turkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [115Z047]; TUBITAKTurkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK)en_US
dc.description.sponsorshipThis work was supported by the Scientific and Technological Research Council of Turkey (TUBITAK) under the project number of 115Z047. Authors thank to TUBITAK for this support.en_US
dc.language.isoengen_US
dc.publisherWiley-V C H Verlag Gmbhen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAntitumoren_US
dc.subjectCoumarinen_US
dc.subjectHybrid moleculeen_US
dc.subjectLipase inhibitionen_US
dc.subjectTriazol-3-oneen_US
dc.titleDesign, synthesis, and biological evaluation of coumarin-triazole hybrid molecules as potential antitumor and pancreatic lipase agentsen_US
dc.typearticleen_US
dc.contributor.departmentRTEÜ, Fen - Edebiyat Fakültesi, Kimya Bölümüen_US
dc.contributor.institutionauthorYılmaz, Fatih
dc.contributor.institutionauthorMenteşe, Emre
dc.contributor.institutionauthorÜlker, Serdar
dc.identifier.doi10.1002/ardp.201600369
dc.identifier.volume350en_US
dc.identifier.issue8en_US
dc.relation.journalArchiv Der Pharmazieen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


Bu öğenin dosyaları:

Thumbnail

Bu öğe aşağıdaki koleksiyon(lar)da görünmektedir.

Basit öğe kaydını göster