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Microwave-assisted synthesis of benzimidazoles and their derivatives from 1994 to 2016-A review

Erişim

info:eu-repo/semantics/closedAccess

Tarih

2017

Yazar

Kahveci, Bahittin
Menteşe, Emre

Üst veri

Tüm öğe kaydını göster

Künye

Kahveci, B. & Menteşe, E. (2017). Microwave-Assisted Synthesis of Benzimidazoles and Their Derivatives From 1994 to 2016-A Review. Current Microwave Chemistry, 4(1), 73-101. https://doi.org/10.2174/2213335603666160517154048

Özet

Background: the use of microwave irradiation is an important development for the synthesis of benzimidazoles in the 21st century, and in recent years, microwave-assisted heterocyclic synthesis has gained significant attention in modern drug discovery studies. Benzimidazoles are an important group in the field of medicinal chemistry because of a wide range of biological activities. This review article provides a collection of studies on the synthesis of benzimidazole derivatives by microwave techniques over a twenty-one years period for an alternative to conventional heating. Methods: Microwave irradiation has been applied for the synthesis of benzimidazoles. the most used method for the preparation of benzimidazoles is condensation of o-diaminobenzene with carboxylic acids or derivatives. Results: Benzimidazoles have a seminal role in drug discovery and these derivatives show an excellent scaffold for the development of novel drugs, polymers, ligands and dys. Microwave heating is a useful technique for the synthesis of benzimidazole derivatives. When compared to the conventional heating methods, many advantages, such as reduction in reaction times, greater yield and purity provision, and less energy requirement, and creation of environmentally friendly conditions have been noted. Conclusion: This review aimed to demonstrate the applications of microwave for the synthesis of benzimidazole and their derivatives from 1994-2016. Microwave-assisted heterocyclic synthesis is a method that can be used to quickly explore and increase diversity in modern chemistry. in the light of the these studies, it could be argued that nearly all of the previously conventionally heated reactions could be performed using the microwave heating. We hope that this review will be helpful to synthesize new potential bioactive benzimidazole derivatives by using this effective method. Time is a very important dimension for researches people. If you save time, you can research much more. in this respect, the microwave technique helps researchers to make effective studies.

Kaynak

Current Microwave Chemistry

Cilt

4

Sayı

1

Bağlantı

https://doi.org/10.2174/2213335603666160517154048
https://hdl.handle.net/11436/2263

Koleksiyonlar

  • FEF, Kimya Bölümü Koleksiyonu [474]
  • WoS İndeksli Yayınlar Koleksiyonu [5260]



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