dc.contributor.author | Mentese, Ahmet | |
dc.contributor.author | Alver, Ahmet | |
dc.contributor.author | Demir, Selim | |
dc.contributor.author | Sümer, Ayşegül | |
dc.contributor.author | Özer Yaman, Serap | |
dc.contributor.author | Karkucak, Murat | |
dc.contributor.author | Aydın Çapkın, Arzu | |
dc.contributor.author | Us Altay, Diler | |
dc.contributor.author | Turan, İbrahim | |
dc.date.accessioned | 2020-12-19T19:49:28Z | |
dc.date.available | 2020-12-19T19:49:28Z | |
dc.date.issued | 2017 | |
dc.identifier.citation | Mentese, A., Alver, A., Demir, S., Sumer, A., Ozer Yaman, S., Karkucak, M., Aydin Capkin, A., Us Altay, D., & Turan, I. (2017). Carbonic anhydrase I and II autoantibodies in Behçet's disease. Carbonic anhydrase I and II autoantibodies in Behçet’s disease. Acta reumatologica portuguesa, 42(1), 26–31. | en_US |
dc.identifier.issn | 0303-464X | |
dc.identifier.uri | https://hdl.handle.net/11436/2289 | |
dc.description | Demir, Selim/0000-0002-1863-6280; | en_US |
dc.description | WOS: 000398616200004 | en_US |
dc.description | PubMed: 28198796 | en_US |
dc.description.abstract | Background: Behcet's disease ( BD) is a vasculitis, seen more frequently around the Mediterranean and the Far East, and evinces with oral and genital ulcerations, skin lesions and uveitis. Carbonic anhydrase ( CA) is a metalloenzyme which is widely distributed in the living world, and it is essential for the regulation of acid-base balance. Anti-CA antibodies have been reported in many disorders, such as systemic lupus erythematosus, Sjogren's syndrome, rheumatoid arthritis, endometriosis, idiopathic chronic pancreatitis, type 1 diabetes and Graves' disease. the goal of this study was to investigate CA I and II autoantibodies in BD. Methods: 35 patients with BD and 29 healthy controls were included in the study and CA I and II autoantibody levels were investigated by ELISA. Results: the CA I and II autoantibody levels of BD group were significantly higher than the healthy group (p= 0.013, p= 0.0001, respectively). A cut-off value of 0.250 absorbance unit (ABSU) for anti-CA I was associated with 34% sensitivity and 100% specificity and a cut-off value of 0.171 ABSU for anti-CA II was associated with 54% sensitivity and 100% specificity for predicting BD. Conclusion: the CA I and II autoantibody levels in pa-tients with BD were found higher compared to control group and the results suggest that CA I and II autoantibodies may be involved in the pathogenesis of BD | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Publisaude-Edicoes Medicas Lda | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Autoantibody | en_US |
dc.subject | Behcet's disease | en_US |
dc.subject | Carbonic anhydrase | en_US |
dc.title | Carbonic anhydrase I and II autoantibodies in Behcet's disease | en_US |
dc.type | article | en_US |
dc.contributor.department | RTEÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü | en_US |
dc.contributor.institutionauthor | Sümer, Ayşegül | |
dc.identifier.volume | 42 | en_US |
dc.identifier.issue | 1 | en_US |
dc.identifier.startpage | 26 | en_US |
dc.identifier.endpage | 31 | en_US |
dc.ri.edit | oa | en_US |
dc.relation.journal | Acta Reumatologica Portuguesa | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |