dc.contributor.author | Kurt, Aysel | |
dc.contributor.author | Tümkaya, Levent | |
dc.contributor.author | Yüce, Süleyman | |
dc.contributor.author | Türüt, Hasan | |
dc.contributor.author | Cüre, Medine Cumhur | |
dc.contributor.author | Şehitoğlu, İbrahim | |
dc.contributor.author | Kalkan, Yıldıray | |
dc.contributor.author | Pusuroğlu, Gökhan | |
dc.contributor.author | Cüre, Erkan | |
dc.date.accessioned | 2020-12-19T19:50:59Z | |
dc.date.available | 2020-12-19T19:50:59Z | |
dc.date.issued | 2016 | |
dc.identifier.citation | Kurt, A., Tumkaya, L., Yuce, S., Turut, H., Cure, M. C., Sehitoglu, I., Kalkan, Y., Pusuroglu, G., & Cure, E. (2016). The protective effect of infliximab against carbon tetrachloride-induced acute lung injury. Iranian journal of basic medical sciences, 19(6), 685–691. | en_US |
dc.identifier.issn | 2008-3866 | |
dc.identifier.issn | 2008-3874 | |
dc.identifier.uri | https://hdl.handle.net/11436/2494 | |
dc.description | cure, erkan/0000-0001-7807-135X; Cure, Medine Cumhur/0000-0001-9253-6459 | en_US |
dc.description | WOS: 000380177400015 | en_US |
dc.description | PubMed: 27482351 | en_US |
dc.description.abstract | Objective(s): Carbon tetrachloride (CCl4) causes pulmonary toxicity. Infliximab (Ib) is a potent inhibitor of tumor necrosis factor-alpha (TNF-alpha). We aimed to investigate whether Ib has a protective effect on CCl4 induced lung injury. Materials and Methods: Rats were divided into control, CCl4, and CCl4+Ib groups. A single dose of 2 ml/kg CCI4 was administered to CCI4 group and a single dose of 7 mg/kg Ib was given to CCl4+Ib group 24 hr before applying CCI4. Results: TNF-alpha, malondialdehyde (MDA), nitric oxide (NO) and caspase-3 levels of the CCl4 group were markedly higher than both the control and CCl4+Ib groups. the CCI4+Ib group had lower histopathological injury than the CCl4 group. Conclusion: Ib as a strong TNF-alpha blocker decreases the production of proinflammatory cytokines, MDA, and oxidative stress leading to a protective effect against CCl4 induced lung tissue injury. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Mashhad Univ Med Sciences | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | Carbon tetrachloride | en_US |
dc.subject | Infliximab | en_US |
dc.subject | Nitric oxide | en_US |
dc.subject | Pulmonary toxicity | en_US |
dc.subject | Oxidative stress | en_US |
dc.title | The protective effect of infliximab against carbon tetrachloride-induced acute lung injury | en_US |
dc.type | article | en_US |
dc.contributor.department | RTEÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü | en_US |
dc.contributor.institutionauthor | Kurt, Aysel | |
dc.contributor.institutionauthor | Tümkaya, Levent | |
dc.contributor.institutionauthor | Türüt, Hasan | |
dc.contributor.institutionauthor | Cüre, Medine Cumhur | |
dc.contributor.institutionauthor | Şehitoğlu, İbrahim | |
dc.contributor.institutionauthor | Kalkan, Yıldıray | |
dc.contributor.institutionauthor | Pusuroğlu, Gökhan | |
dc.contributor.institutionauthor | Cüre, Erkan | |
dc.identifier.volume | 19 | en_US |
dc.identifier.issue | 6 | en_US |
dc.identifier.startpage | 685 | en_US |
dc.identifier.endpage | 691 | en_US |
dc.ri.edit | oa | en_US |
dc.relation.journal | Iranian Journal of Basic Medical Sciences | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |