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dc.contributor.authorCüre, Medine Cumhur
dc.contributor.authorCüre, Erkan
dc.contributor.authorKalkan, Yıldıray
dc.contributor.authorTümkaya, Levent
dc.contributor.authorAydın, İbrahim
dc.contributor.authorKırbaş, Aynur
dc.contributor.authorEfe, Hasan
dc.contributor.authorKurt, Aysel
dc.contributor.authorYüce, Süleyman
dc.date.accessioned2020-12-19T19:55:37Z
dc.date.available2020-12-19T19:55:37Z
dc.date.issued2016
dc.identifier.citationCure, M. C., Cure, E., Kalkan, Y., Tumkaya, L., Aydin, I., Kirbas, A., Efe, H., Kurt, A., & Yuce, S. (2016). The Protective Effect of Adalimumab on Renal Injury in a Model of Abdominal Aorta Cross-Clamping. Advances in clinical and experimental medicine : official organ Wroclaw Medical University, 25(2), 219–226. https://doi.org/10.17219/acem/33250en_US
dc.identifier.issn1899-5276
dc.identifier.urihttps://doi.org/10.17219/acem/33250
dc.identifier.urihttps://hdl.handle.net/11436/2562
dc.descriptioncure, erkan/0000-0001-7807-135X; Cure, Medine Cumhur/0000-0001-9253-6459en_US
dc.descriptionWOS: 000376154400002en_US
dc.descriptionPubMed: 27627553en_US
dc.description.abstractBackground. Adalimumab (ADA) is a potent inhibitor of tumor necrosis factor (TNF-alpha). ADA treatment suppresses proinflammatory cytokines, leading to a decrease or inhibition of the inflammatory process. Objectives. the aim of this study was to investigate the possible protective effects of ADA on oxidative stress and cellular damage on rat kidney tissue after ischemia/reperfusion (I/R). Material and Methods. A total of 30 male Wistar albino rats were divided into three groups: control, I/R, and I/R plus ADA (I/R + ADA); each group comprised 10 animals. the control group underwent laparotomy without I/R injury. After undergoing laparotomy, I/R groups underwent two hours of infrarenal abdominal aortic cross ligation, which was followed by two hours of reperfusion. ADA (50 mg/kg) was administered as a single dose, intraperitoneally, to the I/R + ADA group, 5 days before I/R. Results. the I/R group's TNF-alpha (1150.9 +/- 145.6 pg/mg protein), IL-1 beta (287.0 +/- 32.4 pg/mg protein) and IL-6 (1085.6 +/- 56.7 pg/mg protein) levels were significantly higher than those of the control (916.1 +/- 88.7 pg/mg protein, + ADA groups (864.2 +/- 169.4 pg/mg protein, p = 0.003; 241.4 +/- 33.4 pg/mg protein, p = 0.010; 987.7 +/- 66.5 pg/mg protein, p = 0.004, respectively). To date, a few histopathological changes have been reported regarding renal I/R injury in rats due to ADA treatment whereas I/R caused severe histopathological injury to kidney tissue. Conclusions. ADA treatment significantly attenuated the severity of kidney I/R injury, inhibiting I/R-induced oxidative stress and renal damage. Because of its anti-inflammatory and antioxidant effects, ADA pretreatment may have protective effects on experimental kidney injuryen_US
dc.description.sponsorshipRTEU Bilimsel Arastirmalar Proje Birimi (BAP)Recep Tayyip Erdogan University [2012.106.03.6]en_US
dc.description.sponsorshipThe study was funded from RTEU Bilimsel Arastirmalar Proje Birimi (BAP), project no.: 2012.106.03.6.en_US
dc.language.isoengen_US
dc.publisherWroclaw Medical Univen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectIschemiaen_US
dc.subjectReperfusion injuryen_US
dc.subjectAdalimumaben_US
dc.subjectCarbonic anhydrasesen_US
dc.subjectTumor necrosis factor alphaen_US
dc.titleThe protective effect of adalimumab on renal injury in a model of abdominal aorta cross-clampingen_US
dc.typearticleen_US
dc.contributor.departmentRTEÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.contributor.institutionauthorCüre, Medine Cumhur
dc.contributor.institutionauthorCüre, Erkan
dc.contributor.institutionauthorKalkan, Yıldıray
dc.contributor.institutionauthorTümkaya, Levent
dc.contributor.institutionauthorAydın, İbrahim
dc.contributor.institutionauthorKırbaş, Aynur
dc.contributor.institutionauthorEfe, Hasan
dc.contributor.institutionauthorKurt, Aysel
dc.contributor.institutionauthorYüce, Süleyman
dc.identifier.doi10.17219/acem/33250
dc.identifier.volume25en_US
dc.identifier.issue2en_US
dc.identifier.startpage219en_US
dc.identifier.endpage226en_US
dc.ri.editoaen_US
dc.relation.journalAdvances in Clinical and Experimental Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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