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dc.contributor.authorUral, Ülkü Mete
dc.contributor.authorTekin, Yeşim Bayoğlu
dc.contributor.authorŞehitoğlu, İbrahim
dc.contributor.authorKalkan, Yıldıray
dc.contributor.authorCüre, Medine Cumhur
dc.date.accessioned2020-12-19T19:56:12Z
dc.date.available2020-12-19T19:56:12Z
dc.date.issued2016
dc.identifier.citationUral, U.M., Bayoğlu Tekin, Y., Şehitoğlu, İ., Kalkan, Y., & Cumhur Cüre, M. (2016). Biochemical, Histopathological and Immunohistochemical Evaluation of the Protective and Therapeutic Effects of Thymoquinone against Ischemia and Ischemia/Reperfusion Injury in the Rat Ovary. Gynecologic and obstetric investigation, 81(1), 47–53. https://doi.org/10.1159/000431220en_US
dc.identifier.issn0378-7346
dc.identifier.issn1423-002X
dc.identifier.urihttps://doi.org/10.1159/000431220
dc.identifier.urihttps://hdl.handle.net/11436/2691
dc.descriptionCure, Medine Cumhur/0000-0001-9253-6459en_US
dc.descriptionWOS: 000368969400008en_US
dc.description.abstractAim: To evaluate the antioxidant effects of thymoquinone (TQ) and to investigate the biochemical, histopathological and immunohistochennical changes in experimental rat ovarian torsion. Methods: A total of 48 female adult rats were used in this study and randomly divided into 7 groups: (1) sham operation; (2) bilateral 3-hour ovarian ischemia; (3) 3-hour ischemia and 3-hour reperfusion; (4) and (5) rats were administered 20 and 40 mg/kg of TQ, respectively, before 0.5 h of ischemia, and then 3 h of ovarian ischemia was applied; (6) and (7) 3-hour ovarian ischemia was applied; 2.5 h after the induction of ischemia, rats were administered the same doses of TQ; at the end of 3 h of ischemia, a 3-hour reperfusion was applied. Histologic changes under light microscopy, immunoreactivity for anticaspase-3 and serum levels of malondialdehyde, interleukin-6, catalase and glutathione peroxidase were noted and compared between the 7 groups. Results: Ischemia and ischemia/reperfusion cause a deterioration of biochemical and histopathological parameters. Administration of TQ seems to reverse these alterations and alleviate the injury. Antioxidant defense mechanisms appear to be enhanced by the administration of TQ. Conclusion: TQ at different doses attenuates ovarian ischemia and ischemia/reperfusion injury in rats. (C) 2015 S. Karger AG, Baselen_US
dc.language.isoengen_US
dc.publisherKargeren_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectThymoquinoneen_US
dc.subjectOvaryen_US
dc.subjectTorsionen_US
dc.subjectIschemiaen_US
dc.subjectReperfusionen_US
dc.titleBiochemical, histopathological and immunohistochemieal evaluation of the protective and therapeutic effects of thymoquinone against ischemia and ischemia/reperfusion injury in the rat ovaryen_US
dc.typearticleen_US
dc.contributor.departmentRTEÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.contributor.institutionauthorUral, Ülkü Mete
dc.contributor.institutionauthorTekin, Yeşim Bayoğlu
dc.contributor.institutionauthorŞehitoğlu, İbrahim
dc.contributor.institutionauthorKalkan, Yıldıray
dc.contributor.institutionauthorCüre, Medine Cumhur
dc.identifier.doi10.1159/000431220
dc.identifier.volume81en_US
dc.identifier.issue1en_US
dc.identifier.startpage47en_US
dc.identifier.endpage53en_US
dc.relation.journalGynecologic and Obstetric Investigationen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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