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dc.contributor.authorKılkış, Buket Tuğ
dc.contributor.authorEr, Kürşat
dc.contributor.authorTaşdemir, Tamer
dc.contributor.authorYıldırım, Mehmet
dc.contributor.authorTaşkesen, Fatih
dc.contributor.authorTümkaya, Levent
dc.contributor.authorKalkan, Yıldıray
dc.contributor.authorSerper, Ahmet
dc.date.accessioned2020-12-19T19:56:29Z
dc.date.available2020-12-19T19:56:29Z
dc.date.issued2015
dc.identifier.citationKilkis, B.T., Er, K., Tasdemir, T., Yildirim, M., Taskesen, F., Tumkaya, L., Kalkan, Y. ve diğerleri (2015). Neurotoxicity of various root canal sealers on rat sciatic nerve: an electrophysiologic and histopathologic study. Clinical Oral Investigations, 19(8), 2091-2100. https://doi.org/10.1007/s00784-015-1447-yen_US
dc.identifier.issn1432-6981
dc.identifier.issn1436-3771
dc.identifier.urihttps://doi.org/10.1007/s00784-015-1447-y
dc.identifier.urihttps://hdl.handle.net/11436/2743
dc.descriptionTasdemir, Tamer/0000-0001-8512-5280; Er, Kursat/0000-0002-0667-4909; Yildirim, Mehmet/0000-0003-1798-5478en_US
dc.descriptionWOS: 000362283100040en_US
dc.descriptionPubMed: 25773448en_US
dc.description.abstractObjectives the aim of this study was to compare the neurotoxicity of various root canal sealers on rat sciatic nerve by electrophysiologic and histopathologic analyses. Materials and methods A total of 40 male rats were randomly divided into five groups: Control, AH Plus, GuttaFlow, Sealapex and Smartpastebio. Sciatic nerves of the rats were uncovered using the surgical procedures, and the prepared sealers were then applied on nerves with a polyethylene tube vehicle for 15 days. Nerve potentials were recorded at initial exposure, 5, 30 and 120 min (early phase), and 15 days (late phase) by an electrophysiologic analysis system for all groups. the obtained measurements were then used to calculate the nerve conduction velocities (NCV). Subsequently, all rats were sacrificed, and their sciatic nerves were removed for histopathologic analysis. Statistical analysis was performed using the Kruskal-Wallis and Mann-Whitney U tests for intergroup variables and the Friedman and Wilcoxon test for intragroup variables. Statistical significance was set at P < 0.05. Results There was no significant difference between early and late phase results in the control group. This group showed little or no lasting damage to nerve tissue. All sealers decreased the NCV in the early phase time periods, but this decrease was only statistically significant in the AH Plus group at 120-min time period (P < 0.0125). During the late phase, the AH Plus and GuttaFlow groups almost reached initial NCV values, and it was lower than the initial values in the Sealapex and Smartpastebio groups. However, this decrease was not statistically significant. When intergroup comparisons were performed, statistically significant differences occurred at 30 min in the Sealapex group and 120 min in the AH Plus group compared with the control group (P < 0.0125). All sealers induced neurotoxicity as a result of degenerative and inflammatory responses of nerve tissue in histologic analysis. Histologic analysis revealed Sealapex and GuttaFlow to be the most and least neurotoxic, respectively. Conclusions All tested root canal sealers exhibited a variable degree of neurotoxicity depending on their chemical compositions.en_US
dc.language.isoengen_US
dc.publisherSpringer Heidelbergen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectNeurotoxicityen_US
dc.subjectRoot canal sealeren_US
dc.subjectAH Plusen_US
dc.subjectGuttaFlowen_US
dc.subjectSealapexen_US
dc.subjectSmartpastebioen_US
dc.subjectRat sciatic nerveen_US
dc.subjectAnimal studyen_US
dc.titleNeurotoxicity of various root canal sealers on rat sciatic nerve: an electrophysiologic and histopathologic studyen_US
dc.typearticleen_US
dc.contributor.departmentRTEÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.contributor.institutionauthorTümkaya, Levent
dc.contributor.institutionauthorKalkan, Yıldıray
dc.identifier.doi10.1007/s00784-015-1447-y
dc.identifier.volume19en_US
dc.identifier.issue8en_US
dc.identifier.startpage2091en_US
dc.identifier.endpage2100en_US
dc.relation.journalClinical Oral Investigationsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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