dc.contributor.author | Bostan, Mehmet | |
dc.contributor.author | Uydu, Hüseyin Avni | |
dc.contributor.author | Karadağ, Zakir | |
dc.contributor.author | Atak, Mehtap | |
dc.contributor.author | Uğurlu, Yavuz | |
dc.contributor.author | Ergül, Elif | |
dc.contributor.author | Şatıroğlu, Ömer | |
dc.contributor.author | Yılmaz, Adnan | |
dc.date.accessioned | 2020-12-19T19:57:05Z | |
dc.date.available | 2020-12-19T19:57:05Z | |
dc.date.issued | 2015 | |
dc.identifier.citation | Bostan, M., Uydu, H.A., Jaradağ, Z., Atak, M., Uğurlu, Y., Ergül, E., Şatıroğlu, Ö., Yılmaz, Ö. (2013). Pleiotropic effects of HDL subfractions and HDL-associated enzymes on protection against coronary artery disease. Acta Cardiologica, 62(18), C40-C41. | |
dc.identifier.issn | 0001-5385 | |
dc.identifier.issn | 1784-973X | |
dc.identifier.uri | https://doi.org/10.1080/AC.70.3.3080638 | |
dc.identifier.uri | https://hdl.handle.net/11436/2813 | |
dc.identifier.uri | https://pubmed.ncbi.nlm.nih.gov/26226707/ | |
dc.description | yilmaz, adnan/0000-0003-4842-1173; duman, hakan/0000-0002-1441-7320 | en_US |
dc.description | WOS: 000357755800011 | en_US |
dc.description | PubMed: 26226707 | en_US |
dc.description.abstract | Objective High-density lipoprotein cholesterol (HDL-C) levels are inversely related to the risk of coronary artery disease (CAD). Alterations in HDL-C subclass distribution and HDL-associated enzyme activities may be more important than total HDL levels for the progression of CAD. We intended to investigate the relationship of HDL-C subclass distribution and HDL-associated enzyme activities with CAD. Method and results Our study included 101 patients with stable coronary artery disease, and 64 healthy subjects. Serum levels of HDL lipoprotein-associated-phospholipase A(2) (HDL-LpPLA(2)), paraoxonase 1 (PON1), and HDL subfraction distribution were measured. We found increased small HDL (sHDL) subfractions in patients with one-vessel disease (P < 0.001).We also found a reverse correlation between total HDL-C levels and affected vessel number (P <0.05). Plasma HDL-Lp PLA(2) enzyme level was higher in each vessel disease category compared to the control group (P <0.001). However, PON1 enzyme activity in patients with CAD was not statically significant. Plasma sHDL, HDL-Lp PLA(2) enzyme and Lp(a) were significantly different between subjects with CAD and control participants. Conclusions We demonstrated decreased sHDL particles and a lower cardioprotective HDL-LpPLA(2) enzyme activity in all patient subgroups compared to controls. Measurement of total HDL-C level only may not be sufficient to predict CAD risk. | en_US |
dc.description.sponsorship | TUBITAKTurkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [108S289]; Recep Tayyip Erdogan University Research FoundationRecep Tayyip Erdogan University [2008.102.02.2] | en_US |
dc.description.sponsorship | The present study was supported by grants from TUBITAK (grant no: 108S289) and the Recep Tayyip Erdogan University Research Foundation (2008.102.02.2). | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Taylor & Francis Ltd | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | Atherosclerosis | en_US |
dc.subject | High-density lipoprotein subfraction | en_US |
dc.subject | Lipoprotein-associated phospholipase A2 | en_US |
dc.subject | Paraoxonase | en_US |
dc.title | Pleiotropic effects of HDL subfractions and HDL-associated enzymes on protection against coronary artery disease | en_US |
dc.type | article | en_US |
dc.contributor.department | RTEÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü | en_US |
dc.contributor.institutionauthor | Bostan, Mehmet | |
dc.contributor.institutionauthor | Uydu, Hüseyin Avni | |
dc.contributor.institutionauthor | Karadağ, Zakir | |
dc.contributor.institutionauthor | Atak, Mehtap | |
dc.contributor.institutionauthor | Uğurlu, Yavuz | |
dc.contributor.institutionauthor | Ergül, Elif | |
dc.contributor.institutionauthor | Şatıroğlu, Ömer | |
dc.contributor.institutionauthor | Yılmaz, Adnan | |
dc.identifier.doi | 10.1080/AC.70.3.3080638 | |
dc.identifier.volume | 68 | en_US |
dc.identifier.issue | 18 | en_US |
dc.identifier.startpage | C40 | en_US |
dc.identifier.endpage | C41 | en_US |
dc.relation.journal | Acta Cardiologica | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |